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Preparing method for self-healing polysaccharide hydrogel

A hydrogel and self-healing technology, which is applied in the field of preparation of self-healing polysaccharide hydrogel, can solve the problems of poor controllability, too fast oxidation rate, and uneven oxidation degree of products, and achieve easy biodegradation, reaction The effect of simple process and abundant raw materials

Active Publication Date: 2016-06-01
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the research reports choose sodium periodate as the oxidant to convert the adjacent hydroxyl groups on the polymer into a pair of aldehyde functional groups. Due to the strong oxidizing properties of sodium periodate, the polymer will be degraded in a large amount during the reaction. At the same time, the oxidation rate is too fast, which leads to the uneven oxidation degree of the product and poor controllability of the reaction.

Method used

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  • Preparing method for self-healing polysaccharide hydrogel
  • Preparing method for self-healing polysaccharide hydrogel
  • Preparing method for self-healing polysaccharide hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1) 1-allyl-3-methylimidazolium chloride salt ionic liquid dissolves cellulose

[0031] Weigh 38.0g of ionic liquid into a 100mL three-necked bottle, cut the wood pulp cellulose into pieces, dry it in vacuum at 60°C for 24 hours, weigh 2.0g of dried wood pulp cellulose, add it to a three-necked bottle, and heat at 95°C until the cellulose Dissolve completely (about 2h), stop heating and cool to room temperature.

[0032] 2) Preparation of cellulose acetoacetate

[0033] Heat the cellulose ionic liquid solution dissolved in step 1) to 110°C, protect it with nitrogen, weigh 19.5g of tert-butyl acetoacetate and add it dropwise into a three-necked flask. After reaching room temperature, the reaction mixture was added dropwise into a large amount of methanol solvent to precipitate a precipitate. The product was washed with methanol solvent in a Soxhlet extractor for 24 hours, filtered with suction, and dried in vacuum at 60° C. for 12 hours to obtain cellulose acetoacetate p...

Embodiment 2

[0037] 1) 1-allyl-3-methylimidazolium chloride salt ionic liquid dissolves cellulose with embodiment 1

[0038] 2) prepare cellulose acetoacetate with embodiment 1

[0039] 3) A cellulose acetoacetate solution with a concentration of 1 wt% was prepared with deionized water, and a chitosan solution with a concentration of 1 wt% was prepared with a 1 wt% acetic acid solution. At room temperature, 1.2g of 1wt% chitosan solution was added to 1.2g of 1wt% cellulose acetoacetate solution, mixed on a vortex shaker, and a gel phenomenon appeared within 150s.

Embodiment 3

[0041] 1) 1-allyl-3-methylimidazolium chloride salt ionic liquid dissolves cellulose with embodiment 1

[0042] 2) prepare cellulose acetoacetate with embodiment 1

[0043] 3) A cellulose acetoacetate solution with a concentration of 0.5 wt% was prepared with deionized water, and a chitosan solution with a concentration of 0.5 wt% was prepared with a 1 wt% acetic acid solution. At room temperature, 1.2g of 0.5wt% chitosan solution was added to 1.2g of 0.5wt% cellulose acetoacetate solution, mixed on a vortex shaker, and a gel phenomenon appeared within 6min.

[0044] See figure 2 , the hydrogel that embodiment 2 makes is cut into 4 fritters, wherein two fritters are stained with rhodamine B ( figure 2 a), put together ( figure 2 b), After standing at 25°C for 40 minutes, the border between the stained gel and the unstained gel became blurred ( figure 2 c), while the four gels are connected as a whole ( figure 2 d).

[0045] See image 3 , the hydrogel ( image 3 a...

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Abstract

The invention relates to a preparing method for self-healing polysaccharide hydrogel. The preparing method comprises the steps that cellulose is added into ionic liquid to be dissolved, the mixture is then cooled to the room temperature, and a cellulose solution is obtained; the cellulose solution is heated and dripped with tert-butyl acetoacetate under the protection condition of introducing nitrogen, a reaction is carried out at the constant temperature, the solution is then cooled to the room temperature, purified and subjected to vacuum drying, and acetoacetic acid cellulose is obtained; under the room temperature, a chitosan solution is added into the acetoacetic acid cellulose solution, oscillated and mixed, and the self-healing polysaccharide hydrogel is obtained. The polysaccharide hydrogel prepared through the method has the self-healing performance, and has the pH responsiveness at the same time. The preparing method is simple in process, rich in raw material and suitable for modification of most polysaccharide derivatives; meanwhile, due to the good biocompatibility of cellulose and chitosan, the prepared polysaccharide hydrogel has good application prospects in the fields such as tissue engineering repair, medicine controlled release and biological bionics.

Description

technical field [0001] The invention belongs to the field of hydrogel preparation, in particular to a preparation method of self-healing polysaccharide hydrogel. Background technique [0002] Hydrogel is a three-dimensional network polymer with a certain degree of crosslinking, which can absorb water and swell but is insoluble in water. Due to their excellent properties, hydrogels are widely used in biomedical fields such as drug carriers, tissue engineering and soft materials. Among them, polysaccharide hydrogels, which use renewable polysaccharides as raw materials, have attracted wide attention due to their good biocompatibility and easy degradation. The self-healing hydrogel shows excellent self-healing performance when the material is damaged, which prolongs the life of the gel material and increases the safety of the material. In recent years, the preparation of self-healing hydrogels mainly utilizes dynamic covalent bonds and non-covalent bonds. Common dynamic cova...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/08C08L1/10C08B3/08A61L27/20A61L27/52A61K47/36
CPCA61K47/36A61L27/20A61L27/52C08B3/08C08J3/075C08J2301/10C08J2305/08C08J2401/10C08J2405/08C08L1/10C08L5/08C08L2203/02
Inventor 毛志平刘宏臣隋晓锋徐红张琳萍钟毅孔抵柱
Owner DONGHUA UNIV
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