Arteriovenous vascular network model

A network model, arteriovenous technology, applied in medical simulation, medical informatics, computer-aided medical procedures, etc., can solve the problems of LSA adventitial layer degradation, increased risk of vascular rupture, and increased LSA static pressure.

Active Publication Date: 2018-09-28
CHONGQING UNIV
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Problems solved by technology

In the case of long-term hypertension on the mechanical stretch of the blood vessel wall or cerebrovascular injury, it will lead to the dedifferentiation of LSA smooth muscle cells into a non-contractile type, mak

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  • Arteriovenous vascular network model
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  • Arteriovenous vascular network model

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Embodiment Construction

[0036] The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0037] 1. Materials and methods

[0038]Due to the small diameter of capillaries and the complex exchange of substances, blood and body fluids are separated. In particular, red blood cells that are very close to the diameter of blood vessels may even deform to a certain extent when passing through capillaries, so blood in capillaries no longer satisfies the continuity assumption. Dong et al. used porous media to replace downstream capillary loads in a computational arterial bifurcation model. Some people use porous media instead of capillaries, and use the Darcy percolation model to study the convection, diffusion and heat transfer of biological tissues. The present invention also introduces porous media instead of capillaries to establish a microcirculation calculation model from the middle artery and LSA through capillaries to veins, su...

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Abstract

The invention relates to an arteriovenous vascular network model, and belongs to the field of capillary vessels. The microcirculation model from the artery to the capillary and then to the vein is established. The reflecting mechanism of the capillary in the microcirculation disturbance is discussed, and the appropriate boundary conditions are set. The relationship between the microcirculation disturbance and the cerebral hemorrhage is explored, and the numerical simulation is reviewed. The hypertension is founded as the internal factor as well as the initial and long-term factor that causes cerebral hemorrhage. Microcirculation disorders due to strong external stimuli and mood swings are a direct factor in the initiation of cerebral hemorrhage, and the common effects of these factors arerisky, and the end of the LSA vessel wall is more prone to rupture of the bleeding with respect to other parts. The arteriovenous vascular network model has made a great contribution to the study of the capillary, which is of great theoretical reference and practical significance to the understanding of the mechanism of the rupture of the large cerebral vessels and the prevention of the cerebral hemorrhage in the case of the microcirculation disturbance.

Description

technical field [0001] The invention belongs to the field of capillaries and relates to an arteriovenous vascular network model. Background technique [0002] A large number of clinical results show that among all cerebral hemorrhage cases, hypertensive cerebral hemorrhage accounts for the largest proportion. In hypertensive intracerebral hemorrhage, most of the bleeding area is in the basal ganglia, the terminal lenticulostriate artery (LSA). Wang et al. analyzed 1596 cases of cerebral hemorrhage patients, and the results showed that hypertensive hemorrhage accounted for 83.92% of the total hemorrhage, and basal ganglia hemorrhage accounted for 91.06% of all hypertensive hemorrhage sites. There are many factors affecting cerebral hemorrhage, such as high blood pressure, microcirculation disorder, venous return disorder, etc. Some anatomists even believe that the tortuosity of lenticular artery is also an important reason for its rupture and bleeding. The present invention...

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Application Information

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IPC IPC(8): G16H50/50
CPCG16H50/50
Inventor 张华钱福涛黄锦江刘宁
Owner CHONGQING UNIV
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