Arteriovenous vascular network model

Abstract

The invention relates to an arteriovenous vascular network model, and belongs to the field of capillary vessels. The microcirculation model from the artery to the capillary and then to the vein is established. The reflecting mechanism of the capillary in the microcirculation disturbance is discussed, and the appropriate boundary conditions are set. The relationship between the microcirculation disturbance and the cerebral hemorrhage is explored, and the numerical simulation is reviewed. The hypertension is founded as the internal factor as well as the initial and long-term factor that causes cerebral hemorrhage. Microcirculation disorders due to strong external stimuli and mood swings are a direct factor in the initiation of cerebral hemorrhage, and the common effects of these factors arerisky, and the end of the LSA vessel wall is more prone to rupture of the bleeding with respect to other parts. The arteriovenous vascular network model has made a great contribution to the study of the capillary, which is of great theoretical reference and practical significance to the understanding of the mechanism of the rupture of the large cerebral vessels and the prevention of the cerebral hemorrhage in the case of the microcirculation disturbance.

Description

technical field [0001] The invention belongs to the field of capillaries and relates to an arteriovenous vascular network model. Background technique [0002] A large number of clinical results show that among all cerebral hemorrhage cases, hypertensive cerebral hemorrhage accounts for the largest proportion. In hypertensive intracerebral hemorrhage, most of the bleeding area is in the basal ganglia, the terminal lenticulostriate artery (LSA). Wang et al. analyzed 1596 cases of cerebral hemorrhage patients, and the results showed that hypertensive hemorrhage accounted for 83.92% of the total hemorrhage, and basal ganglia hemorrhage accounted for 91.06% of all hypertensive hemorrhage sites. There are many factors affecting cerebral hemorrhage, such as high blood pressure, microcirculation disorder, venous return disorder, etc. Some anatomists even believe that the tortuosity of lenticular artery is also an important reason for its rupture and bleeding. The present invention...

AI Technical Summary

Problems solved by technology

In the case of long-term hypertension on the mechanical stretch of the blood vessel wall or cerebrovascular injury, it will lead to the dedifferentiation of LSA smooth muscle cells into a non-contractile type, making LSA lose its elasticity

Eventually lead to rise in LSA static pressure, increasing tissue edema

This dedifferentiation also leads to degeneration of the LSA adventitia layer, increasing the risk of vessel rupture

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