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Glycoside compound, preparation method, composition, application and intermediate

A technology of glycosides and compounds, which is applied in the field of glycosides and can solve problems such as difficulties in drug preparation

Active Publication Date: 2019-07-09
HEHUANG PHARMA SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to fill the gaps in the market of drugs with clear therapeutic angiogenesis and the difficulties in drug preparation in the prior art, thereby providing a glycoside compound, its preparation method, composition, application, etc. and intermediates

Method used

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  • Glycoside compound, preparation method, composition, application and intermediate
  • Glycoside compound, preparation method, composition, application and intermediate
  • Glycoside compound, preparation method, composition, application and intermediate

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preparation example Construction

[0549]The preparation method of TG-047 refers to the preparation method of TG-048, and its structure is as follows:

[0550]

[0551] TG-047 identification data

[0552] 1H NMR (400MHz, CD3OD) δ7.18(d, J=8.6Hz, 2H), 6.85(d, J=8.6Hz, 2H), 4.38(d, J=9.5Hz, 1H), 3.90(dd, J =12.0,1.8Hz,1H),3.78(s,3H),3.69(dd,J=12.0,5.4Hz,1H),3.36-3.26(m,3H),3.22(t,J=8.7Hz,1H) ,3.07-2.86(m,4H).

[0553] LRMS (ESI): [M+COOH] -375.0.

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Abstract

The invention discloses a glycoside compound as shown in the formula III and a preparation method, composition, application and intermediate thereof. The preparation method of the glycoside compound is simple, expression of VEGF-AmRNAcan be significantly improved, angiogenesis can be effectively promoted, and a reliable guarantee is provided for research of seeking drugs which promote angiogenesisactivity and treat microcirculation disorders such as cerebral infarction, myocardial infarction and lower limb ischemia.

Description

technical field [0001] The present invention relates to glycoside compounds, their preparation methods, compositions, applications and intermediates. Background technique [0002] Drug research on angiogenesis has attracted much attention in recent years, and angiogenesis has become a potential biological target for drug intervention in the treatment of cancer, vascular diseases and chronic inflammation. Drug development, such as anti-angiogenic inhibitors aimed at reducing tumor angiogenesis, has become a successful therapy for many advanced and aggressive cancers. The discovery of promoting therapeutic cardiovascular neogenesis has provided a new direction for the effective treatment of ischemic vascular diseases, and has become a research hotspot in the medical field. By promoting angiogenesis, it is expected to improve cardiovascular and cerebrovascular diseases (such as angina pectoris, myocardial infarction, stroke) and lower limb ischemia (such as diabetic lower limb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/18C07H15/26C07H15/04C07H1/00A61P9/00A61P9/10C07C69/16C07C43/23
CPCA61P9/00A61P9/10A61K31/7034C07C43/23C07C69/16C07H1/00C07H15/18C07H15/26A61K45/06C07H5/10
Inventor 林国强张建革田平冯陈国詹常森周俊杰
Owner HEHUANG PHARMA SHANGHAI
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