71 results about "Methyl derivative" patented technology

The invention discloses a preparation method for propellant fuel. The preparation method comprises the following steps: uniformly mixing hydrazine or a methyl derivative thereof with a tetrahydrofuransolution of borane to perform a reaction, and after the reaction, performing rotary evaporation on the tetrahydrofuran solution to obtain a first product; adding a first solvent into the first product, then performing washing, and then performing rotary evaporation to remove the first solvent, so as to obtain a hydrazinoborane derivative. According to the method, hydroboration is carried out on ahighly-volatile hydrazine fuel and a methylated derivative of hydrazine, the obtained borohydride of the hydrazine is a colorless non-volatile liquid or a white solid, has no volatility and greatly reduces hazard of the hydrazine fuel, and is a novel aerospace propellant fuel since the ignition delay time of the hydrazine borofluoride is extremely short.

The invention relates to a chitosan or its derivative as drug carrier for carrying red sage root extract and the method, wherein the novel carrying agents include chitosan or sodium alginate for the preparation of drug-carrying beads, tanshinone pharmaceutical carrying agents using the carboxymethyl derivative of chitosan and the quaternary ammonium salt of chitosan, and the aquagel as the carrying agent of red sage root active component prepared from chitosan grafted polyethylene glycol.

Pre-impregnated composite material (prepreg) is provided that can be cured / molded to form composite parts having high compression strength under hot and wet conditions, as well as, high damage tolerance and interlaminar fracture toughness. The matrix resin includes a thermoplastic particle component that includes polyamide particles which are composed of the polymeric condensation product of a methyl derivative of bis(4-aminocyclohexyl)methane and an aliphatic dicarboxylic acid.

To provide a novel production method of oxacephem compound. [Solution] A method of producing Compound (IV) shown by the formula: (wherein R represents an acyl residue; R 1 represents carboxy protecting group; Me represents methyl and X represents halogen), the method comprising the steps of: (First step) letting Compound (I) shown by Formula: (wherein, R represents an acyl residue; R 1 represents carboxy protecting group) react with a halogenating agent in the presence of a base; (Second step) adding MOMe (M represents alkaline metal; Me represents methyl) in the presence of a halogenating agent after completion of the first step; and (Third step) adding a reducing agent after completion of the second step.

The invention discloses a polybenzimidazole material and midbody organic diacid thereof as well as preparation methods thereof. The preparation methods comprise the following steps of: condensing fluorine-containing halide and 3,5-dimethyl phenol under the action of basic catalyst to generate fluorine-containing side-chain-substituted m-dimethyl benzene derivatives then oxidizing the obtained fluorine-containing side-substituted m-dimethyl benzene derivatives by potassium permanganate or nitric acid to obtain side-chain fluorine-containing organic diacid monomer and derivatives thereof; and carrying out polycondensation on the side-chain fluorine-containing organic diacid monomer, compound diacid monomer and tetramine monomer in polyphosphoric acid to generate the side-chain fluorine-containing soluble polybenzimidazole material . The prepared polybenzimidazole material has favorable heat resistance performance and solubility performance and can be used as high-temperature proton exchange membranes, separation membranes, sensors, heat resistance materials, composite materials, caking agents and other functional materials for fuel cells.

The present invention relates to novel 39-desmethoxy-39-methylrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxy-39 -methylrapamycin derivatives in the treatment of cancer and / or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.

There is provided a novel, useful dehydroxyfluorination agent containing sulfuryl fluoride (SO2F2) and an organic base that is free from a free hydroxyl group in the molecule. According to the present dehydroxyfluorination agent, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in large-scale use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, for example, 4-fluoroproline derivatives, 2′-deoxy-2′-fluorouridine derivatives, optically-active α-fluorocarboxylate derivatives, and monofluoromethyl derivatives, even in large scale.

The invention provides a process for fermenting rapamycin with high yield, and belongs to a method for preparing antibiotics by utilizing fermentation of microorganism in the technical field of biology. According to the method, enzymolytic cotton seed powder, dextrin, glycerinum, yeast extract, L-lysine, KH2PO4, K2HPO4, (NH4)2SO4 and trace elements as culture media, wherein the trace elements contain Co<2+>, glycerinum and phosphate buffer are fed in the early phase of the fermenting culture process, and L-pipecolic acid and shikimic acid are fed in the synthesizing phase. By adopting the method, the methyl derivative can be reduced in the growing phase, and the content of rapamycin is increased; intermediate products can be reduced, and rapamycin can generate key enzyme activity; the beneficial effect of high yield of rapamycin can be achieved.

The total synthesis and evaluation of key analogs of vancomycin containing single atom changes in the binding pocket are disclosed as well as their peripherally modified, N-(hydrophobe-substituted) derivatives exemplified by a N-4-(4′-chlorob-phenyl)-methyl derivative and their pharmaceutically acceptable salts are disclosed. Their evaluation indicates the combined pocket and peripherally modified analogs exhibit a remarkable spectrum of antimicrobial activity and truly impressive potencies against both vancomycin-sensitive and -resistant bacteria, and likely benefit from two independent and synergistic mechanisms of action. A pharmaceutical composition containing a contemplated compound or its pharmaceutically acceptable salt is disclosed, as is a method of treating a bacterial infection in a mammal by administering an antibacterial amount of a contemplated compound or its salt as above to an infected mammal in need of treatment.

The invention provides a method for synthesizing 7-Acetyleno quinone methide compounds that is safe and inexpensive. The method avoids the need for extremely cold reaction temperatures and unlike the prior art does not require any highly explosive materials. The method comprises the steps ofa) performing a condensation reaction between 3,5-di-tert-butyl-4-hydroxybenzaldehyde and a secondary amine thereby forming a secondary amine quinone methide intermediate;b) removing water from the secondary amine quinone methide intermediate by azeotropic distillation;c) adding the dehydrated secondary amine quinone methide intermediate to an organic medium containing a metal acetylide to form a Mannich base intermediate; andd) adding a release agent to the Mannich base intermediate to yield a 7-Acetyleno quinone methide.

The invention discloses a pre-lithiated silicon-oxygen negative electrode material as well as a preparation method and application thereof. The method comprises the steps of (1) mixing a biphenyl methyl derivative with a first organic solvent to obtain a biphenyl methyl derivative solution; (2) mixing metal lithium with the biphenyl methyl derivative solution to obtain a Li-biphenyl methyl derivative compound; and (3) mixing silicon monoxide particles with the Li-biphenylmethyl derivative compound, carrying out pre-lithiation, and carrying out solid-liquid separation so as to obtain the pre-lithiated silicon-oxygen negative electrode material. Micron-sized silicon-based negative electrode particles are soaked in a solution with the Li-biphenylmethyl derivative compound as a chemical pre-lithiation reagent, lithium ions in the compound make contact with the silicon-oxygen negative electrode particles, and the pre-lithiated silicon-oxygen negative electrode material with the surface coated with an artificial SEI film and lithium embedded inside is formed.

Pre-impregnated composite material (prepreg) is provided that can be cured / molded to form composite parts having high compression strength under hot and wet conditions, as well as, high damage tolerance and interlaminar fracture toughness. The matrix resin includes a thermoplastic particle component that includes polyamide particles which are composed of the polymeric condensation product of a methyl derivative of bis(4-aminocyclohexyl)methane and an aliphatic dicarboxylic acid.

The invention discloses a preparation method of a formaldehyde adsorbent, and belongs to the technical field of adsorbing materials. According to the preparation method, Tofu is taken as a raw material; natural mildewing of Tofu is realized, and then mildewed Tofu is mixed with fresh milk for fermentation; under the action of mucor, proteins in Tofu and milk are degraded into amino acids; diatomite is taken as a raw material, citric acid is adopted for impurity removing so as to increase the specific surface area and the porosity of diatomite; diatomite is loaded with guanidine sulfamate via acylation and esterification of guanidine sulfamate, so that crosslinking reaction of guanidine groups and hydroxy groups with formaldehyde is realized, bridged bonds are formed, and immobilization of formaldehyde is realized; and at last, modified diatomite and amino acids are subjected to immersion together so as to load diatomite with the amino acids via adsorption, reaction of amino groups and guanidine groups in the amino acids with formaldehyde is realized so as to form hydroxymethyl derivatives, and removing of formaldehyde is realized. The formaldehyde adsorbent possesses excellent adsorption effect; indoor air secondary pollution is avoided; service life is long; and the formaldehyde adsorbent is worthy of popularization and application.

A new high-yield, easily industrialized process for synthesizing compounds of formula (IV), in which X1 and X2, the same or different, are linear or branched C1-C8 alkyls, n and m are 0, 1 or 2, with the proviso that n and m are not simultaneously 0; or (OX1)n and (OX2)m taken together form an O-T-O group where T is chosen from —CH2—, —CH2CH2, —CH2CH2CH2—, —C(CH3)2—. The process comprises treating a chloromethyl derivative (I) with an alkaline acetate to form the intermediate acetylderivative (II); the intermediate (II) is to hydrolysed to form the alcohol (III); the alcohol (III) is then oxidised in the presence of air and catalysts to obtain the desired derivative (IV). The process runs its course within a short period of time, with high yields and high selectivity; in addition, the process does not require purification and separation of the intermediates and can therefore be favourably conducted in a single batch.

The invention belongs to the field of new materials, and particularly relates to low-shrinkage cable material resin and a preparation method thereof. According to the method, a 1, 3-dioxane-5, 5-dimethyl-(9CI) derivative (A), 2-hydroxymethyl-1, 3-propylene glycol (B), epichlorohydrin (C) and diisocyanate (D) are used as raw material, and the novel low-shrinkage cable material resin containing thespiro orthoester structure is prepared through ester exchange, ring opening, ring forming, polycondensation and other reactions. The wear resistance and oil resistance of the cable material are effectively improved, the resin has the advantage of low volume shrinkage, and the product is expected to have wide market space in the field of special cables, especially 5G communication cables.

Compounds of the formula useful for the treatment of such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder (including trichotillomania), social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addition, sexual dysfunction (including premature ejaculation), and related illnesses.

The invention relates to an acidity water base fracturing fluid which is prepared by an acidity multiple-effect thickening agent for fracturing, wherein the acidity multiple-effect thickening agent is obtained by carrying out chemical stem grafting reaction on carboxymethyl derivatives of vegetable gelatins such as guar gum, sesbania glue, tonka-bean glue and the like. The acidity water base fracturing fluid prepared by using the acidity multiple-effect thickening agent can meet the using requirement without the addition of a bactericide, a clay stabilizing agent, a surface active agent, a demulsifying agent and a foaming agent. Under the condition that each performance index of the fracturing fluid is comparative to that of the traditional fracturing liquid, the method has the advantages of enabling operating working procedures to be simplified, being beneficial to the increasing of the quality of fluid and reducing conditions needed for monitoring and the construction procedure and time.

The invention discloses an application of a fullerene methylene derivative I in perovskite solar cells and a perovskite solar cell. The perovskite solar cell includes a conductive layer, an electron transport layer, a perovskite layer doped with the fullerene methylene derivative I, a hole transport layer and electrodes, which are arranged in sequence into a layered structure. The photovoltaic performance of the solar cell is improved by applying the fullerene methylene derivative I to the solar cell.

An object of the present invention is to provide a capsule formulation comprising a phosphonooxymethyl derivative of ravuconazole which suppresses delay in dissolution due to storage regardless of an encapsulated amount of the phosphonooxymethyl derivative of ravuconazole. The present invention provides a capsule formulation comprising an encapsulated material comprising {[(1R,2R)-2-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-1-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl]oxy}methyl dihydrogen phosphate or a pharmacologically acceptable salt thereof, or a solvate of any of the foregoing, and a capsule shell not comprising gelatin.

The invention provides a C19-acylated triptolide methyl derivative. The invention specifically provides a compound shown in the following formula. The groups of the compound are described in the description. The compound can be used as a prodrug for metabolizing to obtain triptolide and can be used for preparing medicine compositions for treating cancer and immunological diseases. The formula is shown in the description.

A process for the production of 4-thiazolylmethyl derivatives are provided. A process for the production of the compound represented by the formula (I):wherein R1 is hydrogen or halogen and Hal is halogen, which comprises reacting 4-methylthiazole with N-halosuccinimide in a solvent in the presence of a radical initiator.

The present invention discloses nitromethylene derivatives and the uses thereof. These derivatives are obtained by adding ring structure onto the known nitromethylene compounds, by which both their stability for light and their liposolubility are increased. Furthermore, by using the substituents linked to ether bond, the steric orientation of the nitro group and the liposolubility of the compounds are controlled. The insecticidal activity tests show that the compounds and their derivatives of the invention display high efficiency on killing various destructive insects with piercing-sucking type or scratching type mouthparts, such as aphid, leafhopper, plant hpooer, thrips and white fly.

PCT No. PCT / JP97 / 03536 Sec. 371 Date Mar. 26, 1999 Sec. 102(e) Date Mar. 26, 1999 PCT Filed Oct. 3, 1997 PCT Pub. No. WO98 / 14423 PCT Pub. Date Apr. 6, 1998The present invention provides an aminomethylene derivative represented by general formula (I): wherein A is a cyclic oxo group selected from the group consisting of following general formulae (a), (b), (c), (d) and (e): wherein R1, R2, R3, R4 and R5 each independently represent H, an alkyl group or the like; R6, R7 and R8 each independently represent an alkyl group or the like; R1 and R2 or R7 and R8 may combine with each other to form a tetramethylene group or the like; R represents an alkyl group optionally containing OH or O; and n is an integer of 0 to 4, a process for the same, and the use thereof. The derivatives have an excellent ultraviolet absorption ability and a high optical stability.

The invention discloses a method for separating and analyzing a non-alkaline nitrogen compound in a petroleum component. The method comprises the following steps: dissolving the petroleum component in an organic solvent, adding an alkylate reagent to react for 12-48h at the temperature of 0-80 DEG C and filtering to get the filtrate; mixing the filtrate with a C5-C7 alkane solvent to separate the sediment; dissolving the sediment in the organic solvent, and adding a dealkylation reagent to react for 12-48h at the temperature of 50-150 DEG C; performing column chromatography isolation on the obtained mixed solution, and removing the sulfocompound to obtain the methylated non-alkaline nitrogen compound; and detecting the obtained nitride by a gas chromatography-mass spectrometer. By adopting the method for separating and analyzing the non-alkaline nitrogen compound in a petroleum component, the non-alkaline nitride can be converted to N-methyl derivative and can be completely separated from the hydrocarbon and a complex matrix of the other heteroatom compounds; and the method is suitable for analyzing the molecular organization of the low-content non-alkaline nitride in the petroleum component.

The invention relates to the technical field of a synthesis method of 1-oxacephalosporin-3-epoxymethylene derivatives as a synthetic intermediate of 1-oxacephalosporin for resisting microbes and especially relates to a preparation method of 1-oxacephalosporin-3-epoxymethylene derivatives shown in the formula (I). The preparation method is characterized in that a 1-oxacephalosporin-3-methylene derivative shown in the formula (II) is efficiently and selectively epoxidized into a 1-oxacephalosporin-3-epoxymethylene derivative by hydrogen peroxide in the presence of a catalyst. The 1-oxacephalosporin-3-epoxymethylene derivative and a derivative of a mercaptotetrazole alkali metal salt shown in the formula (III) undergo a reaction and the reaction products are dehydrated under acidic conditions to form a corresponding 1-oxacephalosporin intermediate shown in the formula (IV). The preparation method has the advantages that a halogen addition reaction is avoided; the easily available catalyst is used; a clean and environmentally friendly oxygen source is used; a reaction process is not carried out at a low temperature; equipment corrosion caused by halogens in industrial production is avoided; an investment of expensive special-purpose equipment is reduced; a risk generation rate is greatly reduced; and 1-oxacephalosporin preparation processes are simple and can be operated easily. Therefore, the preparation method has large competitiveness in industrial production.

The invention provides a boron-dipyrromethene derivative and a nano-particle, preparation methods thereof, and applications of the nano-particle. The derivative is a 2,6-bis(triphenylamino)-1,3,5,7-tetramethyl-8-triphenylamino-boron-dipyrromethene derivative, and has a structure represented by formula I. The invention also provides the preparation method of the boron-dipyrromethene derivative. Theinvention further provides the nano-particle formed by packaging the boron-dipyrromethene derivative in an amphiphilic polymer distearoyl phosphoethanolamine-polyethylene glycol. The nano-particle has the characteristics of good water dispersibility, excellent stability and excellent biocompatibility, can rapidly enter HeLa cells and emit red fluorescence in the cells in several seconds, and canbe used in noninvasive cell tracking and long-term imaging of tumors in vivo as a long-term cell tracer to realize intracellular ultrafast imaging and long-term bioimaging.