42 results about "Macrophage phagocytosis" patented technology

The invention relates to the composition and preparation method of a cisplatin microparticle system with lower cost, higher cisplatin drug loading amount and the effect of shielding macrophage phagocytosis. methoxypolyethylene glycol 2000 ‑Sodium polyglutamate copolymer (MPEG 2000 ‑P(GluNa) 2000 ) as the carrier and cisplatin. Under the conditions of the preparation method required by the patent, the prepared cisplatin nanoparticles have a higher drug loading capacity, and can better shield the phagocytosis of macrophages during the blood circulation process in the body, and have better tumor tissue distribution.

A family of bioactive compounds identified in self-resolving inflammatory exudates is disclosed. The compounds give UV chromophores characteristics of a conjugated triene double bond system coupled to an auxochrome allylic to the triene. Further elucidation of the compounds reveals that they have an oxylipin backbone conjugated to a peptide or amino acid moiety via an auxochrome. In some embodiments the auxochrome is sulfur. However, the auxochrome may be NH, CH2 or O. The compounds have potent bioactivity, in vitro, and, in vivo, including promoting resolution of infection, stimulating macrophage phagocytosis of bacteria; protecting tissues from neutrophil mediated damage, promoting tissue repair and regeneration and preventing or limiting second organ reflow / reperfusion damage.

The invention relates to 6 saturated fatty chain acid Glu-Asp-Gly tripeptide amide conjugates with immunosuppressive activity in a general formula CH3 (CH2)n-CO-Glu-Asp-Gly I. In saturated fatty chain acid, n is equal to 6, 8, 10, 12, 14 or 16. The invention also relates to a preparation method and application of the conjugates as an immunosuppressant. An experimental result of the saturated fatty chain acid Glu-Asp-Gly tripeptide ester which has the inhibition effects of splenic lymphocyte mitogen breeder reaction and macrophage phagocytosis activity indicates that the conjugates of the invention have excellent immunosuppressive action and can be clinically used as an immunosuppressant.

The invention belongs to the field of traditional Chinese medicines and particularly relates to a traditional Chinese medicine composition having an immunity boosting function, a preparing method thereof and uses of the composition. Channel tropisms, properties and flavors of traditional Chinese medicines comprising ginseng, Chinese magnolia vine fruit, dwarf lilyturf tuber, barbary wolfberry fruit and danshen root are fully considered in the composition, and a ratio of the traditional Chinese medicines is selected to allow the traditional Chinese medicines to be matched and cooperated according to a "monarch, minister, assistant and guide" compatibility relation, thus allowing the composition to be acted on focuses and fully exerting the immunity boosting function. Experiments prove that the composition can increase the serum murammidase level of mice, enhances in-vitro macrophage phagocytosis functions of the mice to a certain degree, and can be adopted as a potential immunity boosting medicine.

The invention relates to 12 saturated fatty chain alcohol His-Gly-AA tripeptide ester conjugates with immunosuppressive activity in a general formula His-Gly-AA-O-CH2-(CH2)nCH3 I, wherein AA stands for Glu or Lys. In saturated fatty chain alcohol, n is equal to 6, 8, 10, 12, 14 or 16. the invention also relates to a preparation method and application of the conjugates as an immunosuppressant. An experimental result of the saturated fatty chain alcohol His-Gly-AA tripeptide ester which has the inhibition effects of splenic lymphocyte mitogen breeder reaction and macrophage phagocytosis activity indicates that the conjugates of the invention have excellent immunosuppressive action and can be clinically used as an immunosuppressant.

The invention relates to a method for inhibiting euPTX3 to treat nasopharyngeal carcinoma by an amino acid sequence, comprising administering an effective amount of the amino acid sequence to a subject in need. The amino acid sequence can be used to inhibit euPTX3 from promoting the migration and invasion of nasopharyngeal carcinoma cells, promoting angiogenesis and inhibiting macrophage phagocytosis to further treat nasopharyngeal carcinoma.

The invention discloses a system for characterizing macrophage phagocytosis microorganisms of pompanos. The pompanos are dissected and separated through a surgical knife and tweezers to obtain heads and kidneys; the heads and the kidneys are abraded through a cell sieve to obtain cell suspension containing macrophages, and the macrophages of the heads and the kidneys are obtained through a Percoll solution density gradient centrifugal tube. The survival amount of cells cultured in vitro through a trypan blue dyeing manner is counted, and the survival condition in one week is detected. The system is used for carrying out a phagocytosis experiment, and phagocytosis conditions of nocardia, yeast and the like of the pompanos by the head and kidney macrophages of trachinotus ovatus are determined, and a phagocytosis function is observed. An experiment result of the system shows that the macrophages of the pompanos can be extracted very well, and the survival condition and the phagocytosis condition of the macrophages of the pompanos can be observed very well. The system disclosed by the invention lays a foundation for further researches on physiology, pathology and toxicology of the macrophages of the pompanos.