44 results about "Exudate/transudate" patented technology

The invention discloses a highly air-permeable and degradable drug-loaded skin wound dressing and a preparation method and equipment thereof, belonging to the technical field of new medical materials. The highly air-permeable and degradable drug-loaded skin wound dressing of the present invention comprises components (percentage by weight): 45-50% of chitosan lactate; 45-50% of sodium hyaluronate; and 5-10% of antibiotics. The invention uses the composite material of chitosan lactate and sodium hyaluronate as the substrate, and is a porous bioactive dressing loaded with antibiotic drugs. Through the special freezing process, the dressing has vertical pores, high air permeability, high water absorption and moisture retention, thereby increasing the permeability of the wound surface, and can absorb excess exudate in time while keeping the moisture of the wound surface from excessive evaporation. . It plays a long-term and effective role in the treatment of wounds, thereby avoiding the pain caused by frequent dressing changes.

The invention discloses a moist antibacterial hydrogel dressing for curing diabetic foot ulcer, and relates to the technical field of medical instruments and preparation thereof. The dressing is prepared by the following steps: dissolving ionic compounds in sodium alga acid water solution, and obtaining nano-silver sodium alga acid solution through adding reducing agent; adopting the impregnation method, placing the nano-silver sodium alga acid solution in a bacterial cellulose membrane, so as to obtain bacterial cellulose / nano-silver sodium alga acid composite membrane through freeze drying; and immersing the composite membrane in calcium chloride water solution, and obtaining the moist antibacterial hydrogel dressing for curing diabetic foot ulcer. The dressing is a composite hydrogel membrane including bacterial cellulose hydrogel and nano-silver contained calcium alginatehydrogel. The preparation is convenient to operate and low in cost, and the moist antibacterial hydrogel dressing prepared for curing diabetic foot ulcer has the performances of sterilizing, preserving moisture, absorbing wound percolate, quickening wound healing and the like, and is applied to curing wound traumas of diabetic foot ulcer, venous ulcer, pressure sores and donor site wounds at the lower limbs.

The invention discloses an electrospinning nanofiber membrane loaded with self-assembled traditional Chinese medicine component vesicles, and a preparation method and application thereof. Through the electrospinning technology, the water-soluble polymer material and the total glucosides of Centella asiatica are spun into the core layer, and the water-insoluble polymer material and the phospholipid are spun into the shell layer to form an electrospinning nanofiber membrane with a core-shell structure. In the early stage of trauma, the water-soluble material absorbs tissue exudate to expose the API, and the phospholipids encapsulate the free drug to form a vesicle structure to promote drug absorption, which ultimately promotes the formation of vascular endothelial cells and collagen fibers, and accelerates wound healing. The invention creatively applies research hotspots in the field of materials to a drug preparation delivery system, the prepared electrospinning nanofiber membrane is used for tissue regeneration and repair, and animal experiments achieve good results. The invention makes up for the defect that the existing trauma field relies on traditional treatment methods, provides a basis for the existing industrial production, and also provides a new choice for clinicians and patients to treat.

The invention relates to the field of research model and method for evaluation of an anti-bacterial property of a dressing, and in particular to an in-vitro model for measuring silver ion release of asilver-containing dressing. The in-vitro model includes a test cup and a culture tray; the test cup includes a raised portion and a sunken portion that are fixedly connected; a top surface of the raised portion is higher than a top surface of the sunken portion; a cavity is arranged in the test cup; an opening communicating with the cavity is formed on the top surface of the sunken portion; a liquid feeding port communicating with the cavity is formed on the raised portion; and a groove is formed on the culture tray. The invention further provides a method for measuring the silver ion releaseof the silver-containing dressing. According to the in-vitro model and the method provided by the invention, different types of wounds can be simulated; and through an in-vitro test of measuring silver ion release amount and release curve quantitatively at different time points after measuring a contact of a silver-containing dressing specimen with a percolate of a simulated wound, an effective component and an accumulative ion amount of the silver ion released in a dressing product are reflected scientifically and intuitively, and thus a release amount of the silver ion of the silver-containing dressing in a simulated clinical use state is evaluated dynamically.

The invention provides a chitosan-based multi-layer nanofiber membrane dressing. The dressing comprises a chitosan nanofiber membrane, a chitosan-hydrophilic polymer composite membrane and a hydrophilic polymer membrane which are sequentially stacked, wherein the hydrophilic polymer membrane is loaded with nano bioactive glass, and the chitosan-hydrophilic polymer composite membrane adopts a three-dimensional network structure formed by staggering chitosan nanofibers and hydrophilic polymer nanofibers. The chitosan-based multi-layer nanofiber membrane dressing comprises three layers, the chitosan nanofiber membrane on the bottom layer can stop bleeding and resist bacteria for wounds; the chitosan-hydrophilic polymer composite membrane on the middle layer can absorb tissue exudates and keep the wounds wet; the hydrophilic polymer membrane loaded with nano bioactive glass on the top layer gradually releases growth factors in the swelling process and promotes wound healing. The chitosan-based multi-layer nanofiber membrane dressing can respond to different stages of tissue healing to play different roles. The invention further provides a preparation method and an application of the chitosan-based multi-layer nanofiber membrane dressing.

The invention discloses a dressing prepared by using freeze-dried calcium alginate / vaterite calcium carbonate composite microspheres and a preparation method thereof. The dressing comprises composite microspheres loaded with antibacterial drugs and composite microspheres loaded with cell growth factors, and the mixing mass ratio of the two is: 1:1-5; the composite microspheres are composed of uniformly dispersed vaterite carbonate The calcium suspension and the sodium alginate solution are mixed and prepared by using a microfluidic device. The dressing of the present invention uses calcium alginate / vaterite calcium carbonate composite microspheres as the slow-release carrier, so that the slow-release time of the loaded drug and cell growth factor exceeds one week, and frequent dressing changes can be avoided; in addition, the dressing is effective in wound healing In the initial stage, the freeze-dried calcium alginate layer blocks the bleeding site, effectively absorbs the wound exudate, and the antibacterial drugs are released to prevent bacteria from breeding and infecting the wound. The growth factor is slowly and steadily released during the whole period of wound recovery, so as to achieve hemostasis and inhibit bleeding. Bacteria, promote the function of damaged tissue repair and healing.

A portable system for subatmospheric pressure therapy in connection with healing a surgical wound, including a wound dressing dimensioned for positioning relative to a wound bed of a subject and a subatmospheric pressure mechanism dimensioned to be carried or worn by the subject. The subatmospheric pressure mechanism includes a housing having a control unit adapted to draw a vacuum and a canister associated with the housing. The canister has a collection bag disposed therein, which is in fluid communication with the wound dressing to receive exudates from the wound bed. The collection bag is adapted to expand upon receipt of the fluids and has means to release gas from within the collection bag in connection with operation of the control unit. With this arrangement, the canister is attitude independent, i.e., the canister may be positioned on edge, on its side or on its end etc. while still maintaining operation of the control unit. The collection bag may include a hydrophobic vent or material for releasing the gases. In another embodiment, the collection bag comprises a gas permeable material. The collection bag may include one of pleats or bellows.

The present invention relates to a multi-layer wound dressing for applying negative pressure to a wound. The dressing member includes a bioabsorbable layer for placement in contact with a wound; a fluid impermeable occlusive outer layer; a fluid porous transport layer positioned between the outer layer and the bioabsorbable layer; and a fluid conduit in fluid communication with the delivery layer for coupling to a negative pressure source. The delivery layer includes a plurality of fluid passages between the catheter and the bioabsorbable layer to allow fluid to pass through the layers of the dressing member to and from the bioabsorbable layer. The bioabsorbable layer includes a plurality of apertures to enable exudate flow from the wound to the delivery layer.