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184 results about "Diabetic foot ulcer" patented technology

Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of the diabetic foot. Wound healing is an innate mechanism of action that works reliably most of the time. A key feature of wound healing is stepwise repair of lost extracellular matrix (ECM) that forms the largest component of the dermal skin layer. But in some cases, certain disorders or physiological insult disturbs the wound healing process. Diabetes mellitus is one such metabolic disorder that impedes the normal steps of the wound healing process. Many studies show a prolonged inflammatory phase in diabetic wounds, which causes a delay in the formation of mature granulation tissue and a parallel reduction in wound tensile strength.

Electrosurgical method and system for treating foot ulcer

An electrosurgical method for treating foot ulcer, including diabetic foot ulcer, comprising: positioning an active electrode in close proximity to the ulcer, the active electrode being disposed on a distal end of an electrosurgical shaft; applying a high-frequency voltage potential difference across the active electrode and a return electrode in the presence of an electrically conductive fluid, the voltage potential being sufficient to generate plasma at the active electrode; and stimulating the ulcer with the active electrode to increase blood flow, remove unhealthy tissue and induce the body's natural healing response.
Owner:ARTHROCARE

Walking boot for diabetic and other patients

An orthopedic walking boot promotes rapid healing of diabetic foot ulcerations by lowering the maximum peak pressure imposed upon the foot. The walker has a hard unyielding shell which is designed for walking. The shell closely and rigidly supports a mid-sole in a foot-shaped bed. The mid-sole has a foot-shaped cavity with rounded sides adapted to form resilient support for the heel, arch and sides of a foot in addition to the bottom of a foot. A conformable inner-sole is adapted to fit over the foot-shaped cavity in the mid-sole and be compressed in response to foot pressure between the sides and bottom of the foot and the sides and bottom of the foot-shaped cavity in the mid-sole thereby compensating for small differences between the shape of the foot and the shape of the cavity. Weight applied to the foot is transferred to the walking shell by contact between the sides of the foot, arch, and heel and the arch, heel and sides of the foot-shaped cavity as well as the bottom of the cavity thereby decreasing the peak or maximum unit pressure on the plantar surface of the foot. A breathable bootie which wraps the foot and lower leg in a protective “cocoon” is preferably secured to the upper surface of the insole thereby preventing foreign materials from entering the foot cavity.
Owner:BREG

Use of treprostinil to treat neuropathic diabetic foot ulcers

The present invention describes novel methods for using 9-deoxy-2′,9-α-methano-3-oxa-4,5,6-trinor-3,7-(1′,3′-interphenylene)-13,14-dihydro-prostaglandin F1 (also known as Treprostinil) or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and / or prevention of foot ulcers in subjects with diabetic neuropathy. The invention also relates to kits for treatment and / or prevention of foot ulcers, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.
Owner:UNITED THERAPEUTICS CORP

System and method for assessing wound

The wound assessing method and system of the present teachings provide a convenient, quantitative mechanism for diabetic foot ulcer assessment.
Owner:WORCESTER POLYTECHNIC INSTITUTE

System and method for assessing wound

InactiveUS20170076446A1Easy-to-use and affordableImage enhancementMedical imagingDiabetic ulcersBiomedical engineering
The wound assessing method and system provide a convenient, quantitative mechanism for diabetic foot ulcer assessment.
Owner:WORCESTER POLYTECHNIC INSTITUTE

Multifunctional temperature-sensitive gel composite dressing for wound healing and preparation and usage thereof

The invention discloses a multifunctional temperature-sensitive gel composite dressing for wound healing and preparation and usage thereof. The dressing comprises a quaternized chitosan derivative and an aldehyde-terminated temperature-sensitive polymer, a mass ratio of the two components is 1:15-1:25, wherein a molecular weight of chitosan for preparing quaternized chitosan is between 100 thousands and 1000 thousands, the degree of deacetylation is above 90%, and the degree of quaternized substitution is 10%-45%. The dressing is a thick liquid easy to apply to a wound at room temperature, and after it is applied to the wound, a gel film coating may form within 1 min. The temperature-sensitive gel composite dressing prepared based on the invention has autonomous antibacterial and anti-inflammatory effects and good film-forming stability, may also provide a wet environment and a sustained drug release function and is useful for treating and healing wounds such as diabetic foot ulcers.
Owner:SUN YAT SEN UNIV

Pharmaceutical Compositions Containing Hyaluronic Acid and Collagenase for the Topical Treatment of Wounds, Burns and Ulcers

The present invention concerns new compositions containing hyaluronic acid or the derivatives thereof in association with the proteolytic enzyme collagenase (and relative pharmaceutical formulations) for the preparation of a dressing for topical treatment of various kinds of wounds, burns of varying depth, pressure sores, vascular ulcers and diabetic foot ulcers as well as for the treatment of hypertrophic and keloid scars.
Owner:FIDIA FARM SPA

Pharmaceutical composition and device for preventing, treating and curing ulcers on a diabetic foot and other wounds, which includes snail slime from the species cryptophalus aspersus or helix aspersa muller and pharmaceutically acceptable carriers and/or additives

The present invention is related to a pharmaceutical composition comprising snail slime of Helix aspersa müller (Cryptophalus aspersus) (5% to 50%) and marigold extract, propolis and / or almond oil and pharmacologically accepted additives for the prevention additives and / or pharmaceutically acceptable excipients to form a formulation of intermediate to high viscosity (200 to 1000 Pa-s). This invention also relates to the use of a composition which can be formed as a cream or a gel, is preferably soaked in gauze, and shaped as a bandage or sock for the treatment and cure of diabetic foot ulcers and other severe wounds, particularly those associated with diabetes, gout, Lesch Nyhan syndrome or other conditions to the skin, including, keratosis, onychomycosis, ringworm, among others.
Owner:MUCIDERM

Foot tub special for diabetic patient

The invention provides a foot tub special for a diabetic patient. The foot tub comprises an outer tub and an inner tub. The inner tub is arranged inside the outer tub through a spiral height adjusting mechanism. A vibration spring is arranged between tub bottoms of the outer tub and the inner tub. A vibration original piece is arranged at the bottom of the outer side of the inner tub. A stretchable strut is installed on the outer side wall of the outer tub. A magnifying lens is arranged on a handheld handle of the stretchable strut. A sponge tip is arranged at the tail end of the stretchable strut. The two outer side walls of the outer tub are provided with inspectoscopes in a hinged mode. Supporting feet are fixedly installed below the inspectoscopes. A water thermometer is arranged on the inner side wall of the inner tub. A temperature alarm device is arranged between the outer tub and the inner tub and connected with the water thermometer. The foot phenomenon can be conveniently inspected during a foot bath of the patient, the inducements such as the water temperature of the foot bath, the foot soaking time and scrubbing with strength which are likely to damage the feet of the diabetic patient are limited, diabetic feet can be prevented and found easily while the diabetic patient has a comfort foot bath, traditional Chinese medicine compositions are combined, the treatment effect reaches 95%, and the foot tub is safe, comfortable and quite good in effect.
Owner:THE FIRST PEOPLES HOSPITAL OF NANTONG

MG53 (mitsugumin53) mutant as well as preparation method and application thereof

The invention provides an MG53 (mitsugumin53) mutant and a preparation method thereof. The mutant is a serine-site mutant of MG53 protein in a Coiled-coil structural domain, and the mutant results in inactivation of MG53 phosphorylation. Meanwhile, the MG53 protein mutant can be used for preventing or treating diseases related to cellular membrane damage, such as diseases related to myocardial cell injury, diseases related to ulcer, trauma with a wound, particularly a difficult-to-heal wound, intestinal leakage, kidney injury and the like. The diseases related to myocardial cell injury can include one or more diseases related to following symptoms: myocardial ischemia, heart ischemia, heart ischemia / reperfusion injury, myocardial infarction, cardiac failure, arrhythmia and cardiac rupture. The diseases related to ulcer include one or more of following diseases: chronic ulcer, peptic ulcer, diabetic foot ulcer, diabetic foot gangrene and chronic gastric ulcer. Besides, the invention further provides a dry powder preparation, a spray preparation, a gel preparation and an emulsion containing MG53 or MG53 mutant as well as preparation methods of the preparations.
Owner:MUDANJIANG YOUBO PHARMA CO LTD

Diabetic foot ulcer (DFU) classification method based on convolutional neural network

A diabetic foot ulcer (DFU) classification method proposed in the invention based on a convolutional neural network includes the steps of creating a DFU data set, marking a region of interest (ROI), adding data, pre-processing training patches, conventional machine learning, and constructing a DFU network. The process includes: first collecting foot images of a DFU patient and a healthy person asdata sets and plotting ROIs, then adding data using a combination of various image processing techniques for network training, next, pre-processing the obtained patches, normalizing each pixel, and finally constructing a DFU network including input data, parallel convolutions, a fully connected layer, and an output classifier. The method of the invention utilizes an advanced convolutional neural network to process the input data more effectively and efficiently; and has high sensitivity and can effectively distinguish the characteristic differences between the healthy skin and the DFU, therebygreatly shortening the processing time.
Owner:SHENZHEN WEITESHI TECH

Chinese medicinal detoxifying myo-regeneration paste for treating diabetic foot ulcer and preparation method thereof

The invention provides Chinese medicinal detoxifying myo-regeneration paste for treating diabetic foot ulcer, which belongs to the fields of traditional Chinese medical science and traditional Chinese medicines. The paste is prepared from the following raw materials in percentage by weight: 6 to 11 percent of rhubarb, 6 to 11 percent of golden thread, 6 to 11 percent of amur corktree bark, 14 to 19 percent of plaster, 12 to 17 percent of sinkiang arnebia root, 14 to 20 percent of Chinese angelica, 7 to 11 percent of angelica dahurica, 2 to 5 percent of calomel, 7 to 11 percent of dragon's blood and 23 to 30 percent of bee wax. Animal experiments and clinical researches prove that the Chinese medicinal detoxifying myo-regeneration paste provided by the invention has the effects of activating blood, dissolving stasis, removing putrefaction, regenerating myo, clearing away heat and toxic material and the like, has the advantages of keeping the surface of a wound wet, increasing the content of cell factors, namely, a vascular endothelial growth factor (VEGF) and a platelet-derived growth factor (PDGF) and promoting relevant gene expressions of muscles and blood vessels, along with definite curative effect, simple and convenient operation, economy, safety and no toxic or side effect and special significance in treating diabetic foot ulcer.
Owner:韩会民 +1

Methods for enhancing healing of diabetic foot ulcers by injecting epidermal growth factor (EGF)

InactiveUS7465704B2Prevents amputationAssisting in limb preservationOrganic active ingredientsPowder deliveryAngiologySurgical department
The invention relates to the use of Epidermal Growth Factor (EGF) in a preferably-injectable pharmaceutical composition which is administered by means of infiltration into and around chronic cutaneous ischaemic lesions in order to prevent diabetic foot amputation. Said composition can be administered to recently-created surgical surfaces damaged by the effect of acute reperfusion with oxygenated blood following prolonged ischaemia, thereby preventing further surgical procedures and favouring the preservation of the extremity. The aforementioned composition can be used to improve (i) the cell microenvironment, thereby increasing the reparative and defensive capacity and viability of the is tissues and (ii) the cicatrisation of cutaneous ischaemic lesions, thereby stimulating cell proliferation. The invention is suitable for use in human, veterinary and experimental medicine, specifically in vascular angiology and surgery, dermatology, burn treatment and reconstructive surgery and geriatric medicine. Said composition can be used for recalcitrant ulcers which are associated with lesions in the macro and / or microvasculature, patients with inadequate lymphatic and / or venous return and ulcers or other lesions which are difficult to cicatrise and / or heal.
Owner:CENT DE ING GENETICA & BIOTECNOLOGIA

Hyperspectral technology for assessing and treating diabetic foot and tissue disease

This invention relates generally to an index map comprising both pressure and perfusion information from a diabetic patient foot for the purpose of treatment. The index map may also be a map of perfusion and / or metabolism of the tissue (reflecting oxygen delivery and oxygen extraction), obtained by thermal imaging, hyperspectral imaging, or duplex ultrasound, MRA, CT or laser Doppler imaging. This information aids treatment in prevention of diabetic foot ulceration and amputation and in treatment of tissue compromise to prevent tissue loss in other body regions.
Owner:HYPERMED IMAGING

Skin ulcer treatment

A system and method for facilitating the healing of a skin ulcer, such as a diabetic ulcer, on a treatment region of a body. Ultrasound waves are transmitted to the treatment region. Interferential electrical stimulation is applied to the treatment region, simultaneously with the ultrasound transmission. The treatment region may be massaged with a massaging device during the treatment session. A gel may be applied onto the treatment region to facilitate the ultrasound transmission and electrical stimulation. A measurement system may be used to obtain accurate measurements of the skin ulcer, to provide a quantitative determination of the healing progression.
Owner:BRH MEDICAL LTD

Smart Textile to Predict Risk of Diabetic Foot Ulcer

A system and a method predict risk of diabetic foot ulcer by automatically recognizing and tracking physiological activities of a person using a smart textile that has a plurality of pressure sensors and a plurality of temperature sensors. Pressure data indicative of plantar pressure applied to each of the pressure sensors by the person is received from the smart textile. Temperature data indicative of plantar temperature at each of the temperature sensors is received from the smart textile. Plantar parameters are determined from the pressure and temperature data and plantar responses to activity of the person are determined from the plantar parameters. A risk of the person developing a foot ulcer is determined based upon the plantar parameters and the plantar responses.
Owner:THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZONA

Novel synergistic pharmaceutical composition for topical applications

ActiveUS20130085103A1Increasing antibacterial effectiveness of antibacterial agentImprove breathabilityAntibacterial agentsOintment deliveryDiseaseAdditive ingredient
A synergistic pharmaceutical composition for the preparation of topical formulations for use in prophylaxis and treatment of wounds, burn wounds, skin grafts, pressure ulcers, diabetic foot ulcers and other skin diseases is provided. The composition may include one or more synergistically active ingredients and one or more inactive ingredients. The synergistically active ingredients may include Recombinant Human Epidermal Growth Factor (rh-EGF) (REGEN-D™ of Bharat Biotech International Limited) and / or Platelet Derived Growth Factor (rh-PDGF-BB), silver sulfadiazine (SSD) and chlorhexidine gluconate (CHG). One or more inactive ingredients may comprise carriers, preservatives, emulsifiers, skin emollients and soothers and one or more other constituents.
Owner:BHARAT BIOTECH INTERNATIONAL

Negative pressure drainage debridement device for diabetic feet

Disclosed is a negative pressure drainage debridement device for the diabetic feet. The negative pressure drainage debridement device for the diabetic feet comprises an anti-blocking device, a negative pressure assembly, a drainage bottle and a suction assembly; the anti-blocking device comprises a shell, a liquid inlet pipe, a liquid outlet pipe, a first branch pipe, a second branch pipe and a crushing assembly; the liquid inlet pipe stretches into the shell from one side of the shell and is communicated with the first branch pipe, the first branch pipe is internally and fixedly provided witha filtering net and a conical ring and communicated with a communicating pipe vertically arranged in the crushing assembly, the communicating part is located at the portion, between the filtering netand the fixing end of the conical ring, of the pipe wall of the lower side, the bottom of the communicating pipe is communicated with the feeding end of a crushing cylinder, and a rotating shaft is positioned in the crushing cylinder through a bearing and driven by a motor and is coaxial with the crushing cylinder; the rotating shaft is fixedly provided with a first thread, a second thread, a conical body and a spiral feeding piece from a feeding port of the feeding end of the crushing cylinder to a discharging port in sequence. The negative pressure drainage debridement device can effectively prevent a pipeline from being blocked and work more stably.
Owner:XUZHOU CENT HOSPITAL

Bioactive functional dressing for treating diabetic feet

The invention discloses bioactive functional dressing for treating diabetic feet. The dressing comprises a bioactive functional layer, an antibacterial functional layer, a fluid absorption functional layer and a biotic pressure functional layer sequentially from the bottom up. The dressing is simple in structure and low in production expense, low in cost and convenient to operate at the same time, greatly facilitates treatment of diabetic foot wounds of a doctor and medical care personnel; an active ingredient of the bioactive functional layer has a slow release effect; the dress can effectively stimulate and promote cell activation and regeneration of the surfaces of the diabetic foot wounds and promotes capillary network and nerve repair of the surfaces of the wounds by the action of the biological active ingredient. The dressing has effects of repairing neural and vascular lesions, efficiently resisting infection, absorbing fluid and evacuating pus on the surfaces of the wounds, and a biomechanical effect on the wounds, is multifunctional and good in treatment effect and can be widely applied to clinical treatment and nursing of the diabetic feet.
Owner:JINAN UNIVERSITY
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