57 results about "Controlled studies" patented technology

The present invention is primarily directed to methods of genetic cluster analysis for use in determining the homogeneity and / or heterogeneity of a population or sub-population. Determination of the heterogeneity or homogeneity of a population sample is important in many areas including DNA fingerprinting in forensics and population-based studies such as clinical trials, case-control studies of risk factors, and gene mapping studies.

The invention belongs to the field of multi-rotor unmanned aerial vehicle loading transport control study and provides a set of nonlinear robust control algorithm for a multi-rotor unmanned aerial vehicle suspension loading system so as to improve the control robustness and control accuracy of the system under strong alternating wind disturbance. According to the technical scheme, the disturbance rejection control method for the unmanned aerial vehicle suspension loading system disclosed by the invention comprises the following steps: constructing a dynamitic model of the multi-rotor unmanned aerial vehicle suspension loading system; designing a disturbance observer; performing mathematical derivation so as to obtain an observation model of the disturbance observer based on a kinematical equation of the provided multi-rotor unmanned aerial vehicle suspension loading system. The method disclosed by the invention is mainly applied to the occasion of multi-rotor unmanned aerial vehicle loading transport control.

The invention discloses a MAC address preaging method for controlling study, which is provided with a software MAC address table and a hardware MAC address table, the method comprises the following steps that when a MAC address which is inexistent in the hardware MAC address table is found by an exchanger hardware, the MAC address is reported to the exchanger hardware; the exchanger software retrieves in the MAC address table, if the MAC address is not retrieved, the MAC address is defined into a new MAC address, and the pre-studying, studying or discarding action selection is performed to the new MAC address, otherwise, the MAC address is processed correspondingly according to the pre-studying, studying or presaging state of the MAC address. The invention realizes the ageing and studying seamless connection of the MAC address through ensuring that the commonly-used MAC address firstly studies and firstly obtains software and hardware resource after being aged enforcedly, so as to improve the stability and the reliability of the system.

The invention provides a flow chamber for loading disturbance flow on co-cultured cells, which comprises a polycarbonate upper plate, a polycarbonate middle plate, a medical silicon membrane, a polycarbonate lower plate and a stainless steel fastener. The polycarbonate upper plate is provided with two co-cultured placement holes; the polycarbonate lower plate comprises an inlet, an inlet fluid buffer slot, an outlet, an outlet fluid buffer slot and a metal joint; the middle of the polycarbonate middle plate is provided with one first rectangular cavity; the middle of the medical silicon membrane is provided with a second rectangular cavity; the inlet fluid buffer slot is communicated with the first rectangular cavity through the second rectangular cavity; and the inlet fluid buffer slot is positioned below the front end of the polycarbonate middle plate and is far away from the first rectangular cavity. In the invention, not only can the influence between two types of relative cells be considered, but also the disturbance and laminar flow can be simultaneously and respectively loaded on the co-cultured cells. The flow chamber is convenient to use, is very easy to disassemble and assemble and is easy to obtain the cells acted on by different flow fields for carrying out subsequent control study.

The invention discloses a multi-freedom-degree synchronous electromyographic control method based on deep learning, and belongs to the technical field of electromyographic control. According to the method, the problems that in an existing multi-freedom-degree synchronous electromyographic control study model, only information of one freedom degree is learned, the interrelation between freedom degrees is lacked, and information in electromyographic signals is missed when electromyographic signal features are extracted are solved. According to the method, wrist original electromyographic signalsand corresponding motion information of subjects are synchronously collected and stored, an initial multi-freedom-degree synchronous electromyographic control model is set up based on a one-dimensional convolution neural network, the collected original electromyographic signals are input into the initial multi-freedom-degree synchronous electromyographic control model, each set of wrist motion information is correspondingly taken as an output object, and therefore the trained multi-freedom-degree synchronous electromyographic control model is obtained; and the wrist original electromyographicsignals of the subjects are collected to be input into the final multi-freedom-degree synchronous electromyographic control model, the motion information of the wrists can be predicted, and the motion information can be applied to mechanical arm control.

The invention belongs to the technical field of medical data analysis, relating to an analysis method of grading parameters of disease-related factors, in particular to an analysis method of comprehensive grading parameters for sarcoidosis and atypical tuberculosis. The invention uses clinical epidemiology case to contrast with research approach, the patients of sarcoidosis and tuberculosis through attending confirmation of morbid biopsy and treatment are chosen to carry out retrospective analysis of single factor, the variables of risk factor, clinical feature, iconography and pathology characteristics having distinguishing meanings for the two above diseases are chosen in combination with the standards of the prior art, weighting scores of each variable is calculated, a grading model is established, and the comprehensive grading parameters for sarcoidosis and atypical tuberculosis are analyzed through a model software. The method of the invention can provide important reference basis as well as rapid and high-efficient auxiliary analysis for clinical application.

Controlled studies demonstrate that methods using soy related peptides inhibit H3 acetylation, reduce expression of HMG CoA reductase and increase LDL receptor and Sp1 expression in mammals. The present disclosure is generally directed to using lunasin peptides and / or lunasin peptide derivatives to 1) inhibit H3 acetylation, 2) reduce expression of HMG CoA reductase, 3) increase LDL receptor expression or 4) increase Sp1 expression in a mammal. In at least one exemplary embodiment of the present disclosure, an effective amount of lunasin peptides or lunasin peptide derivatives and one or more enzyme inhibitors is provided to a mammal to 1) inhibit H3 acetylation, 2) reduce expression of HMG CoA reductase, 3) increase LDL receptor expression or 4) increase Sp1 expression in a mammal.

The invention provides a city water supply pipe network pressure regulation and control movable type system and a pipe network pressure regulation and control method achieved by adopting the system, and relates to the field of water supply pipe network pressure regulation and control study. The city water supply pipe network pressure regulation and control movable type system and the pipe network pressure regulation and control method achieved by adopting the system aim at solving the problem which exists in an existing mode that since a pressure increasing pump station or a pressure reducing station is installed to achieve pressure increasing or pressure reducing for a water supply pipe network, a pressure increasing pump or a pressure reducing valve needs to be installed at a fixed site, the pump or the valve cannot be moved after being installed, the space is wasted, and the pressure regulation and control mode is single. Pipe sections at the two ends of a pressure reducing pipeline penetrate through a container truck to extend to the portion outside the truck, the pipe sections at the two ends are used for being connected with an inlet pipe section of a testing area pipe network, and a control cabinet is used for receiving the pressure of the front pipeline and the rear pipeline to obtain a pressure difference and flow data before and after pressure regulation and control, and transmitting the data to a control plate card; pressure data of the most disadvantageous point is transmitted to the control plate card in a wireless mode through a first GPRS antenna on a first pressure sensor, and the control plate card is used for controlling the control cabinet to regulate and control the pressure of the testing area pipe network. The control plate card is used for regulating and controlling the pressure of the testing area pipe network.

The invention discloses a cross coupling rigidity excitation simulation device of a magnetic levitation centrifugal compressor. The device comprises a T-shaped groove table, and a high-speed motor, an elastic coupling, a radial magnetic levitation bearing module, a flexible magnetic levitation rotor, an excitation magnetic levitation bearing and a measuring module transversely arranged on the T-shaped groove table and connected in sequence; the measuring module comprises multiple radial eddy current displacement sensors; large and small dynamic balance discs are in interference assembly in the middle position of the flexible magnetic levitation rotor; the radial eddy current displacement sensors are connected with a signal input end of a digital controller; and an output end passes through a power amplifier to connect with a front radial magnetic levitation bearing, a back radial magnetic levitation bearing and the excitation magnetic levitation bearing. The device is simple in structure, convenient in use and operation and high in system stability, uses magnetic field force for exciting the flexible magnetic levitation rotor to form cross coupling rigidity interference, and can perform control studies of the cross coupling rigidity interference inhibition of the magnetic levitation centrifugal compressor on a testbed.

Disclosed are a device and a method for synchronizing electric arc welding fusion depth information and welding data collection information. The device for synchronizing the electric arc welding fusion depth information and the welding data collection information is composed of a welding cabinet, a scriber, an electromagnetic valve, an air pump, a controller and a scribe board, wherein the scriber is formed by sequentially connecting an air cylinder, a scribing needle fixture and a scribing needle from top to bottom, the air cylinder is fixedly connected with the welding cabinet, and the air pump, the electromagnetic valve and the air cylinder are connected into an air circuit through air pipes. The method for synchronizing the electric arc welding fusion depth information and the welding data collection information includes steps: inputting a control signal of a controller into a control end of the electromagnetic valve so as to achieve air circuit switching, change of moving directions of the scribing needle and control of scratches on the scribe board, generated by the scribing needle; confirming data collection starting and ending positions on a work piece through marks on the scribe board after welding, cutting, polishing and eroding the work piece on a position of the maximum fusion depth along the welding direction, identifying a fusion line and performing fitting, and thereby generating the fusion depth information synchronous with the collection data. The device and the method for synchronizing the electric arc welding fusion depth information and the welding data collection information are used for rapidly measuring the welding fusion depth information offline and synchronizing the welding fusion depth information with the welding data collection information, and thereby can facilitate modeling and control studies, which are related to the fusion depth.

The invention discloses composition with a function of clearing peculiar smell in an oral cavity. The composition is prepared from raw materials in parts by weight as follows: 1-20 parts of common lophatherum herbs, 10-50 parts of purslane, 10-40 parts of chrysanthemums, 20-40 parts of honeysuckles, 1-20 parts of lotus leaves and 1-30 parts of mint. The composition is prepared from six medicinal and edible Chinese herbs. A pharmacological experiment can inhibit multiple anaerobic bacteria and helicobacter pylori causing the peculiar smell of the oral cavity, and a clinical controlled study result further proves that the composition can relieve the subjective symptom of the patients with peculiar smell in the oral cavity.

The invention discloses a heavy gas leakage diffusion and control study experiment method. The method comprises the steps of executing control technologies via orthogonal experiments to obtain key factors influencing properties and influence degrees; performing fine control experiments according to the obtained key factors to confirm a quantitative relation between the key factors and the influence degrees; performing heavy gas leakage diffusion and control experiments via orthogonal experiments to determine key factors influencing the concentration and distribution of heavy gas cloud under different conditions and influence degrees, tracing the direction of mass energy, disclosing a control mechanism, and seeking an acting relation among the control technologies; and establishing a mathematical model according to the obtained acting relation among the control technologies, key factors and influence degrees, and predicting evaporation rates and down-wind LFL (Lower Flame Limit) longest distance under different environmental conditions, leakage conditions and corresponding control technologies. The method has a very good effect on controlling LNG (Liquefied Natural Gas) leakage harm by studying various control technologies.

Controlled studies demonstrate that products and related methods using soy related peptides lower total and LDL cholesterol levels in individuals. In one exemplary embodiment of the present disclosure, a product containing an effective amount of lunasin peptides that lowers cholesterol levels in an individual that consumes the lunasin peptides is provided. In another exemplary embodiment of the present disclosure, a composition containing an effective amount of lunasin peptides or lunasin peptide derivatives and one or more enzyme inhibitors is provided. In a related exemplary embodiment of the present disclosure, a method for lowering or reducing cholesterol levels in an individual is provided where a product containing an effective amount of lunasin peptides to an individual is provided and a claim that the product lowers or reduces cholesterol, total cholesterol, LDL cholesterol or lipid levels in an individual that consumes the composition is made.

The invention provides a traditional Chinese medicine compound used for treating cardiovascular and cerebrovascular diseases, which is made of the following components by weight ratios: 5-25 portions of red sage root, 5-25 portions of astragalus root, 5-25 portions of pseudostellaria root, 3-23 portions of polygala aureocauda dunn, 3-23 portions of shepherds purse, 1-6 portions of notoginseng, 3-23 portions of oldenlandia, 3-23 portions of eucommia bark, 3-23 portions of prepared rehmannia root, and 1-6 portions of prepared licorice. The components of the traditional Chinese medicine compound can produce synergetic effect, thus treating the cardiovascular and cerebrovascular diseases with high efficiency. Clinical control studies prove that the traditional Chinese medicine compound has the total effective rate of 96.9% on treating cerebral embolism and the total effective rate of 100% on treating hypertension. Also, the traditional Chinese medicine compound has the advantages of quick effect and good and lasting curative effect.

The invention discloses a prodrug of retegravir as well as a preparation method and application of the prodrug. The structural formula of the prodrug of the retegravir is shown as a formula I in the specification. A liquid chromatograph-mass spectrometer is adopted to detect the concentration of R0 in blood after gavage of the obtained compound, and remdesivir injection and gavage are adopted to perform control study, so that the modified compound is found to have good bioavailability, the concentration of R0 in blood exceeds 50% of the average value of an injection administration group, and the concentration of R0 in blood exceeds more than 3 times of that of an oral remdesivir hydrochloride administration group.

The invention relates to a DNA (deoxyribonucleic acid) sequence tag for identifying the sex difference of fenneropenaeus chinensis and an application thereof. High-throughput sequencing is carried out on mixing pools of DNA of female individuals and male individuals respectively by a high-throughput sequencing means, bioinformatics analysis is carried out on the sequencing results to screen DNA sequence fragments with significant difference in the female and male mixing pools, the obtained differential fragments are verified in the female and male individuals from different sources, finally a DNA sequence tag which can be used for identifying the sex of fenneropenaeus chinensis is obtained, and accurate identification of the genetic sex of fenneropenaeus chinensis can be achieved by utilizing the DNA sequence tag. The method has the characteristics of high efficiency, accuracy and reliability and has an extensive application prospect in fenneropenaeus chinensis sex identification, sex determination and differentiation mechanisms and sex control studies.

Controlled studies demonstrate that methods using soy related peptides inhibit H3 acetylation, reduce expression of HMG-CoA reductase and increase LDL receptor and Sp1 expression in mammals. The present disclosure is generally directed to using lunasin peptides and / or lunasin peptide derivatives to 1) inhibit H3 acetylation, 2) reduce expression of HMG-CoA reductase, 3) increase LDL receptor expression or 4) increase Sp1 expression in a mammal. In at least one exemplary embodiment of the present disclosure, an effective amount of lunasin peptides or lunasin peptide derivatives and one or more enzyme inhibitors is provided to a mammal to 1) inhibit H3 acetylation, 2) reduce expression of HMG-CoA reductase, 3) increase LDL receptor expression or 4) increase Sp1 expression in a mammal. Additionally, lunasin will protect against, prevent, or reduce: 1) the expression of Matrix metalloproteinase (MMP-1), 2) collagen breakdown, 3) photoaging and 4) the formation of skin wrinkles.

A method for the measurement and analysis of skin fluorescence across multiple subjects. The method includes illuminating each subject with an excitation wavelength, detecting a peak fluorescence level within a corresponding emission wavelength range, determining relative levels of skin glycation for each subject, and evaluating the efficacy of a skin treatment based on the relative levels of skin glycation. The method can include ranking and normalizing the peak fluorescence levels for each subject, and the method is suitable for use in placebo-controlled studies of anti-glycation skin therapies.

The invention comprises a composition of inosine and orotic acid or a salt thereof, and its methods of use in treating, maintaining and enhancing the health of the heart, and specifically the integrity of the myocardium. The effective combination of inosine and orotic acid / orotate effectively improves various medical parameters that are widely used to assess cardiac function and structure. These include EKG and VCG recordings, quantitative assessments of work capacity and athletic performance, clinically relevant observations, and direct biochemical, histological and ultrastructural analyses. The observations and controlled studies in mice, rats, rabbits, cardiology patients and high performance human athletes (cyclists) consistently support the effectiveness of the combination of inosine and orotic acid / orotate in both preventing and reversing damage to the myocardium resulting from physical stress.

The invention provides a short-time traffic flow prediction method based on an improved time-space association KNN (K-Nearest Neighbor) algorithm. The core concept of the invention is that firstly, astate vector capable of reflecting a change trend of traffic flow is constructed; further, K state vectors which are the nearest neighbor to a current time period of a target detector are searched from two dimensions of a time domain and a space domain of historical state vectors; weight allocation of the K state vectors is analyzed; and a flow value at a next moment is predicted. According to theinvention, a short-time flow sequence of an intersection can be excellently predicted, the technical support is provided for improving intelligence and scientificity of flow prediction and promotingoperation efficiency of traffic flow of the intersection, and the short-time traffic flow prediction method belongs to the field of the traffic control study.

The invention discloses a pathogenic gene Prodh of cryphonectria parasitica and an application thereof. The gene contains two exons and one intron, has DNA (deoxyribonucleic acid) total length of 1585bp and cDNA (complementary DNA) total length of 1413bp and codes 438 amino acids. A protein expressed by the gene is shown in SEQ.ID.No.3 and is used for regulating and controlling pathogenesis of cryphonectria parasitica and a molecular mechanism of conidia production. Experiments prove that the sporulation quantity of a deletion mutant obtained after the gene is replaced by a hygromycin resistance gene hph is obviously reduced, and pathogenic scabs formed by the deletion mutant on in-vitro Chinese chestnut tree branches are obviously smaller than the pathogenic scabs produced by a wild type strain, thus sporulation quantity reduction and pathogenicity loss of cryphonectria parasitica are caused by deletion of the gene Prodh. The gene Prodh as well as an expression vector, a host and the like thereof has important significance in plant disease control drug and cryphonectria parasitica control study. Besides, transcription of the gene Prodh is inhibited after cryphonectria parasitica is infected with a hypovirus. The protein coded by the gene is probably a target after infection with the hypovirus. The mutual effects of the hypovirus and the gene have important significance in studying the molecular mechanism of virus-host interaction.

Epidermal growth factor (EGF) produced by an excretory recombinant approach was tested for its efficacy in treating various skin wounds. In a randomized double blind controlled study, local cream samples prepared with human EGF at a final concentration of as low as 0.02% (g / g) in topically suitable carrier were found to have an enhancing effect on the recovery of diabetes foot ulcers. This promotional effect is statistically significant and has resulted in a reduced mean healing time of over 3 weeks when compared with that of control. Both the 0.02% (g / g) and 0.04% (g / g) human EGF supplemented samples in comparison with control showed a trend of stimulatory effect when a recovery of 50% of an ulcer was considered. The EGF samples were also shown to be highly effective in promoting treatments of wounds resulting from bedsores and surgeries.

The invention discloses a preparation method of polyhedral composite nano-micelle. The technical problem to be solved is that assembly control study on protein of biparental block copolymer is very limited. The preparation method comprises the following steps: (1) preparing silk fibroin with a molecular weight range of 56435-68552 Da and alpha-casein with the molecular weight of 23600 Da; (2) respectively preparing the silk fibroin and the alpha-casein into solutions with mass concentrations of 0.25-0.35 percent; (3) mixing the silk fibroin solution and the alpha-casein solution prepared in step (2) according to a mass ratio between 8 to 1 and 5 to 1, performing ultrasound treatment for 30-45min, injecting the mixture into a reactor of a synthesis device, and continuously assembling for 6-18 hours; (4) adding a fixing cross-linking agent, and continuously fixing to obtain the polyhedral composite nano-micelle. By adopting the method, the silk fibroin and the alpha-casein with certain molecular weights are taken as raw materials to prepare the polyhedral composite micelle for the first time.

The invention discloses a variable mass center aircraft simulation device and relates to an aircraft simulation device. The invention aims to solve the problems that the conventional aircraft corresponding to a variable mass center control manner does not have good aerodynamic configuration and a side-jet engine manner cannot be maneuvered by fully utilizing aerodynamic force. According to the variable mass center aircraft simulation device disclosed by the invention, two frame coupling shafts are arranged on a support frame; a conical bottom surface of an aircraft shell is hinged with the support frame through the two frame coupling shafts; the conical tip of the aircraft shell is downward; the aircraft shell can swing around the frame coupling shafts; a moving mass body is positioned inside the aircraft shell; the conical tip of the moving mass body is hinged with the conical tip of the aircraft shell; a stepping motor and a gear are arranged on the conical bottom surface of the moving mass body; an arc-shaped movement rack is fixed on the conical bottom surface of the aircraft shell; the gear and the movement rack form a kinematic pair; the stepping motor drives the moving mass body to swing inside the aircraft shell by virtue of the kinematic pair. The variable mass center aircraft simulation device disclosed by the invention is applicable to design and control studies of variable mass center aircrafts.

The invention discloses a method for constructing an in vitro model with dynamic simulation of hepatoma metastasis of human beings, comprising construction of a cell attachment resistant model, construction of the hepatoma cell in vitro metastasis model, identification of the constructed hepatoma in vitro metastasis model, etc. The method of the invention applies high metastasis tendency BEL7402 hepatoma cells to simulate and construct the in vitro model for hepatoma cell metastasis by constructing a model which makes the BEL7402 hepatoma cells deviated from attachment of extracellular matrixes and simulating a condition that transitional cells grows by means of anchorage dependence again when meeting adequate environment. By utilization of the model, control study of carcinoma in situ and tumor during the metastatic process can be performed, and the model can be further taken as a monitoring system for detecting biological behaviors of tumor cells during the metastatic process and judging tumor prognosis. The model has important value in researching a clinical tumor metastatic mechanism and controlling screening of metastasis drugs and also can be taken as a platform for preparing tumor metastasis resistant gene vaccine and establishing a tumor metastasis resistant drug screening technology.

The invention discloses a method for breeding thrips palmi karny. The method comprises the steps of cucumber seedling planting, bemisia tabaci introduction, thrips palmi karny imago introduction, subsequent expanding propagation and the like. Honeydew generated by the excreta of bemisia tabaci is adopted as one of nutritional ingredients in the breeding process of the thrips palmi karny, and is more beneficial to population reproduction. The method is simple in process, low in cost and high in breeding efficiency, the bemisia tabaci and the thrips palmi karny are introduced to leaves in sequence, certain population density (not lower than 100 / plant) is kept, cyclic supply of the thrips palmi karny can be achieved, and the obtained thrips palmi karny is high in survival rate and high in vigor. Compared with other conventional indoor thrips breeding, the labor intensity is low, the efficiency is high, and an important insect source guarantee is provided for continuous control study of biological prevention and control of the thrips.

Marine pathogenic microorganism is an important factor capable of influencing national economical construction, so that pathogenic microorganism detection and control study possesses significant importance on national economical construction. The invention discloses a platform used for rapid direct analysis of microorganisms in environmental microorganism samples based on a quaternary ammonium salt magnetic nanometer material-urease composite sensor. According to the invention, study on recognition mechanisms and reaction kinetics of the quaternary ammonium salt magnetic nanometer material with a microorganism response material is carried out, study on the functional rules of identification response function modes in microorganism rapid detection and microorganism instant expression analysis is carried out. The invention discloses the action relationship of the quaternary ammonium salt magnetic nanometer material-urease composite sensor with microorganisms, conclusion of action rules of a one-stop microbial analyzer with different microorganisms, and provides reference for solving portable and automatic problems in microorganism detection method.