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Wound dressing having bacteriostasis and hygroscopicity

A wound dressing and modified technology, which is applied in the direction of adhesive dressing, non-adhesive dressing, dressing, etc., and can solve the problem of not having antibacterial function

Active Publication Date: 2012-10-24
FOSHAN UNITED MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But these dressings are also not antibacterial

Method used

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  • Wound dressing having bacteriostasis and hygroscopicity
  • Wound dressing having bacteriostasis and hygroscopicity
  • Wound dressing having bacteriostasis and hygroscopicity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Material: chitosan fiber, fineness is 2.0dtex, length is 50 mm, treated with 1% by weight of surfactant and its hygroscopicity contains 8.298 grams of sodium chloride and 0.368 grams of sodium chloride per liter in fiber state Calcium chloride dihydrate solution (solution A) has an absorption rate of 110%; modified cellulose fiber, fineness is 1.4dtex, viscose fiber with a length of 38 mm, treated with carboxymethyl and its hygroscopicity is in the fiber state The absorption rate for a solution (A solution) containing 8.298 grams of sodium chloride and 0.368 grams of calcium chloride dihydrate per liter was 2200%.

[0040] 100 grams of chitosan fibers and 1900 grams of carboxymethylcellulose fibers were uniformly mixed by hand for 5 minutes and then fed to a single cylinder card (Cuarnicard type), where the fibers were further mixed in the card hopper. The fiber web formed after carding is a homogeneous mixture of the fibers. Afterwards, this fiber web is made into nee...

Embodiment 2

[0044] In order to observe the antibacterial properties of the wound dressing of Example 1, evenly coat 0.25ml of 10 6 -10 7 cfu / g of Staphylococcus aureus. The wound dressing according to Example 1 was then cut into 2 x 2 cm and placed in Petri dishes. Continuously culture at a constant temperature of 37°C and observe the growth of bacteria on each plate. figure 1 Bacterial growth / inhibition on the bottom of the wound dressing after 1 day in a Staphylococcus aureus Petri dish is shown for the wound dressing of Example 1.

[0045] From figure 1 According to visual observation, there is little bacterial growth at the bottom of the wound dressing, which shows the good antibacterial performance of the wound dressing of the present invention.

Embodiment 3

[0047] Material: Acylated chitosan fiber, fineness 2.2dtex, length 50 mm, after acylation treatment and its hygroscopicity, in the fiber state, it contains 8.298 grams of sodium chloride and 0.368 grams of calcium chloride dihydrate per liter The absorption rate of the solution (A solution) is 1500%; modified cellulose fiber, the fineness is 1.7dtex, the length is 50 mm, treated with carboxymethyl and its hygroscopicity can contain 8.298 grams of chlorine per liter in fiber state. The absorption rate of the solution (A solution) of sodium chloride and 0.368 g of calcium chloride dihydrate was 1500%.

[0048] Preparation of acylated chitosan:

[0049] Take by weighing the chitosan fiber of 400g, soak with dehydrated alcohol after 30min, dehydration, then chitosan fiber is placed in succinic anhydride-ethanol (894g succinic anhydride, be dissolved in the dehydrated alcohol of 8940ml) solution, 70 ℃ water bath heating for 40min. The fibers are then taken out, dehydrated, and wa...

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Abstract

The invention relates to a wound dressing having bacteriostasis and hygroscopicity, and especially relates to a wound dressing containing chitosan fibers and modified cellulose fibers, a preparation of the wound dressing, and an application of the wound dressing in chronic wounds, such as venous stasis ulcers, pressure ulcers, diabetic foot ulcers and other chronic ulcers.

Description

technical field [0001] The present invention relates to a wound dressing and its use in chronic wounds, such as venous stasis ulcers, pressure ulcers and diabetic foot ulcers and other chronic ulcers. Background technique [0002] As we all know, when choosing a wound dressing to treat a wound, one of the challenges that the nursing staff needs to face is to manage chronic wound exudate while providing the wound with a favorable environment for healing. These favorable environmental conditions include, absorb wound exudates and Keep the wound moist and at the same time effectively inhibit the growth of microorganisms in the wound. [0003] Chitosan fiber has antibacterial effect, among which the NH of chitosan 2 The positive charge carried by the group combines with the negative charge on the bacterial cell wall, thereby inhibiting bacterial growth. In addition, the small molecule chitosan penetrates the cell wall to inhibit the formation of enzymes. This is easy to obser...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28
CPCA61L2300/404A61F13/02A61L15/46A61L15/28A61L15/42A61L15/60A61L15/225A61F13/01008C08L5/08C08L1/28
Inventor 王晓东张大伟莫小慧吕秋兰吴振军
Owner FOSHAN UNITED MEDICAL TECH
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