A chitosan-based multilayer nanofiber membrane dressing and its preparation method and application

A nanofiber membrane and chitosan nanotechnology, applied in the direction of medical formulations, bandages, drug delivery, etc., can solve the problems that are not conducive to the wound healing process, cannot keep the wound moist, and unfavorable wound healing, etc., to promote wound healing, size Uniform controllable and adjustable composition effect

Active Publication Date: 2020-07-14
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the adhesion of powdered chitosan to tissue wounds is not strong, which is not conducive to wound healing, and it degrades slowly, which is prone to side effects such as tissue adhesions and fibrous cysts.
However, the single-component chitosan dressing cannot keep the wound moist, which is not conducive to the healing process of the wound.

Method used

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  • A chitosan-based multilayer nanofiber membrane dressing and its preparation method and application
  • A chitosan-based multilayer nanofiber membrane dressing and its preparation method and application
  • A chitosan-based multilayer nanofiber membrane dressing and its preparation method and application

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preparation example Construction

[0068] The second aspect of the present invention provides a kind of preparation method of chitosan-based multilayer nanofiber membrane dressing, comprising:

[0069] (1) prepare chitosan nanofiber membrane by the method for electrospinning;

[0070] (2) Prepare chitosan solution and hydrophilic polymer solution respectively, and then adopt double-channel electrospinning to prepare chitosan-hydrophilic polymer composite membrane, chitosan-hydrophilic polymer composite film The membrane is a three-dimensional network structure formed by the interlaced arrangement of chitosan nanofibers and hydrophilic polymer nanofibers;

[0071] (3) placing the nano-bioactive glass in the hydrophilic polymer solution, stirring to obtain a mixed solution, and electrospinning the mixed solution to obtain a hydrophilic polymer fiber loaded with nano-bioactive glass. After the spinning is completed, A hydrophilic polymer film loaded with nano-bioactive glass was prepared on the chitosan-hydrophil...

Embodiment 1

[0116] to combine figure 1 Specifically describe a kind of preparation method of chitosan-based multilayer nanofiber membrane dressing, comprising:

[0117] (1) Preparation of chitosan nanofiber membrane

[0118] Weigh 0.7 g of chitosan (CS), and dissolve it in a mixed solution formed by 7 mL of TFA and 3 mL of DMC to obtain a CS solution, place the CS solution in a 37° C. 7% (w / v) CS solution, stored at 4°C for later use;

[0119] Use No. 7 syringe A to draw 4mL of 7% (w / v) CS solution, connect the positive pole of the high-voltage power supply to the needle tip, connect the negative pole to the receiving device, place the needle tube in the push pump, set the voltage to 14kV, and push The speed is 0.1mL / h, and the receiving distance is 12cm. Start the propulsion pump, and turn on the DC voltage infusion pump to push forward at a certain speed after there are droplets dripping from the needle. Combined with the action of the electric field force, the CS electrospinning liq...

Embodiment 2

[0132] A preparation method of chitosan-based multilayer nanofiber membrane dressing, comprising:

[0133] (1) Preparation of chitosan nanofiber membrane

[0134] Weigh 0.5 g of chitosan (CS), and dissolve it in a mixed solution formed by 7 mL of TFA and 3 mL of DMC to prepare a CS solution. Place the CS solution in a 37° C. into a CS solution with a concentration of 5% (w / v), and store at 4°C for later use;

[0135] Use a No. 7 syringe to draw 4mL of 5% (w / v) CS solution, connect the positive pole of the high-voltage power supply to the needle tip, and connect the negative pole to the receiving device. Fix the needle tube on the propulsion pump, set the voltage to 10kV, and the propulsion speed It is 0.05mL / h, and the receiving distance is 15cm. Start the propulsion pump, and turn on the DC voltage infusion pump to push forward at a certain speed after there are droplets dripping from the needle. Combined with the action of the electric field force, the CS electrospinning l...

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Abstract

The invention provides a chitosan-based multi-layer nanofiber membrane dressing. The dressing comprises a chitosan nanofiber membrane, a chitosan-hydrophilic polymer composite membrane and a hydrophilic polymer membrane which are sequentially stacked, wherein the hydrophilic polymer membrane is loaded with nano bioactive glass, and the chitosan-hydrophilic polymer composite membrane adopts a three-dimensional network structure formed by staggering chitosan nanofibers and hydrophilic polymer nanofibers. The chitosan-based multi-layer nanofiber membrane dressing comprises three layers, the chitosan nanofiber membrane on the bottom layer can stop bleeding and resist bacteria for wounds; the chitosan-hydrophilic polymer composite membrane on the middle layer can absorb tissue exudates and keep the wounds wet; the hydrophilic polymer membrane loaded with nano bioactive glass on the top layer gradually releases growth factors in the swelling process and promotes wound healing. The chitosan-based multi-layer nanofiber membrane dressing can respond to different stages of tissue healing to play different roles. The invention further provides a preparation method and an application of the chitosan-based multi-layer nanofiber membrane dressing.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a chitosan-based multilayer nanofiber membrane dressing and a preparation method and application thereof. Background technique [0002] Studies have shown that wound healing is mainly divided into three stages: (1) Inflammatory stage: mainly includes endogenous and exogenous blood coagulation process and formation of hemostatic clot, inflammatory response caused by local aggregation of neutrophils, and subsequent inflammation. Phagocytosis and related immune response; (2) fibrous tissue proliferation phase: mainly characterized by the formation and epithelialization of blood vessels and granulation tissue near the wound; (3) scar repair phase: the role of fibroblasts in the wound Due to the contraction of muscle elastic fibers, cells in the basal layer of the skin undergo mitosis and cell migration to form new epithelial cells to cover the wound, marking the completion of the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/24A61L15/26A61L15/08A61L15/44
CPCA61L15/08A61L15/24A61L15/26A61L15/28A61L15/32A61L15/44A61L2300/112A61L2300/232A61L2300/412A61L2300/418A61L2400/04A61L2400/12C08L1/02C08L5/08C08L29/04C08L71/02
Inventor 赵晓丽陈庆昌
Owner SHENZHEN INST OF ADVANCED TECH
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