The invention discloses a quinolone antibiotic degrading bacterium and application thereof and belongs to the technical field of biological treatment of environmental pollutants. The degrading bacterium is obtained by domestication and purification of livestock manure, and is named as Ochrobactrum sp. JOB, and was preserved in Guangdong Microbiological Culture Collection Center (GDMCC), Guangdong Province Institute of Microbiology on the fifth floor, No.59 Building, No.100 Courtyard, Xianlie Middle Road, Guanzhou City on December 21st, 2016, with a preservation number of GDMCC NO:60132. The degrading bacterium disclosed by the invention is prepared into bacterium suspension or an immobilized microbial agent which can be used for effectively removing quinolone antibiotic pollution in different environmental media such as a water body and soil; compared with a physical absorption method, a chemical degradation method and the like, the quinolone antibiotic degrading bacterium has the advantages of high efficiency, energy conservation, environment friendliness and the like; particularly, a bacterial body is immobilized by using an embedding agent, so that the life of the bacterial body is prolonged; the microbial agent has an excellent action effect and high ability of adaptation to environment.