35 results about "Cyclohexaneacetic acid" patented technology

A conversion process of gabapentin hydrochloride into gabapentin comprising: a) dissolution of gabapentin hydrochloride in a solvent in which the gabapentin hydrochloride and the gabapentin are completely soluble; and b) subsequent addition of an amine that allows the removal of the chloride ion from the solution containing gabapentin hydrochloride, by precipitation of the hydrochloride of the same amine, leaving the gabapentin in solution in free amino acid form.

A process for producing gabapentin, (1-(aminomethyl)-1-cyclohexaneacetic acid) from gabapentin hydrochloride salt. In the disclosed process, the gabapentin hydrochloride is converted to gabapentin using an inorganic base, such as barium hydroxide. Gabapentin hydrochloride is converted to gabapentin sulfate which in turn is converted to free base using barium hydroxide. The process is directed to improvement in the manufacture of gabapentin which would be industrially feasible and effective. Gabapentin obtained following the process of the invention is suitable as a drug especially in the treatment of cerebral diseases such as epilepsy.

The invention relates to a preparation method of an environmental-friendly thermosetting acrylic resin and belongs to the technical field of high polymer materials. The preparation method comprises the following raw materials in parts by weight: acetate solvents at the kettle bottom, a mixture of monomers and initiators, namely methyl methacrylate, tert-butyl methacrylate, styrene, n-butyl acrylate, hydroxy-propyl acrylate, acrylic acid, 1,1-di-tert-butyl peroxide cyclohexane and acetate solvents; supplementary initiators comprising 1,1-di-tert-butyl peroxide cyclohexane and acetate solvents;and diluents comprising the acetate solvents. According to the environmental-friendly thermosetting acrylic resin disclosed by the invention, the content of total benzene series in the resin per 1m<3>is less than 5mg. The powder charge coating prepared by adopting the environmental-friendly thermosetting acrylic resin disclosed by the invention has extremely low benzene content, the temperature resistance reaches 220 DEG C or higher, the value of readily oxidizable substances in the coating is greatly reduced, the total amount on an aluminum foil of 300 square centimeters is less than 1.5ml,fluorescence is not detected in the coating, and any heavy metal does not exist.

The invention relates to a hydroxy acrylic resin suitable for heat-reflecting heat-insulating coatings, belonging to the technical field of hydroxy acrylic resin and a preparation method thereof. Including the following raw materials by weight: kettle bottom material: butyl acetate; mixed monomer dropwise addition: methyl methacrylate, n-butyl methacrylate, lauryl methacrylate, hydroxyethyl methacrylate, methacrylic acid tert-butyl ester, n-butyl acrylate, acrylic acid, 1,1‑bis(tert-butylperoxy)cyclohexane, tert-butyl peroxybenzoate, butyl acetate; supplementary materials 1 and 2 are both: 1,1 ‑Bis(tert-butylperoxy)cyclohexane, butyl acetate; diluting material: butyl acetate. No matter what kind of environment or substrate, the present invention has excellent coating film performance and excellent comprehensive performance.

The invention discloses a medical catheter bonding glue and a preparation method thereof, belonging to the technical field of medical device glue production. According to the mass percentage, the raw materials of the glue include SEBS 1.03-2.86%, tackifying resin 3.14-10%, and the balance is a solvent; wherein the tackifying resin includes C5 petroleum resin and hydrogenated rosin glyceride, and the solvent includes cyclohexane, ethyl acetate and cyclohexanone. In the glue, a suitable type of tackifying resin is selected to improve the bonding strength of the glue; cyclohexanone is added to the solvent to improve the lubricity of the medical catheter; and the solvent with slower volatilization is selected, which greatly prolongs the pot life of the glue At the same time, the solvent selected in the glue has less side effects on human body and less physical harm to workers.

The invention belongs to the technical field of pivalic acid synthesis, and in particular relates to a post-processing method for a pivalic acid synthesis reaction solution. The post-processing method of the pivalic acid synthesis reaction solution is that after the pivalic acid synthesis reaction is completed, a compound extractant is added to the reaction solution, extracted and separated to obtain a pivalic acid extract and a raffinate, and the pivalic acid is rectified. The acid extraction solution is to obtain the pure product of pivalic acid; the compound extraction agent includes a main extraction agent and a co-extracting agent, and the main extraction agent is selected from any one of methylene chloride, chloroform or chlorobenzene or The co-extracting agent is selected from any one or more of cyclohexane, ethyl acetate or isopropyl ether. The post-treatment method of the pivalic acid synthesis reaction solution of the present invention produces less waste water, greatly reduces the pressure on environmental protection, can realize continuous operation at the same time, and has the advantages of high efficiency, environmental protection, low energy consumption, low production cost and the like.

The invention discloses a method for identifying cortex pseudolaricis in a traditional Chinese medicinal compound. The method comprises the following steps: (1) adding a sample onto a polyamide column, eluting with a mixed solution, eluting with an organic solvent A, collecting the eluting liquid, drying by distillation, dissolving residues with the organic solvent to serve as a test-sample solution; (2) treating a cortex pseudolaricis control medicinal material with an organic solvent B, drying the filtrate by distillation, dissolving the residues with the organic solvent B to serve as a control medicinal material solution; and (3) taking 2-6mu L of the test sample solution and 2-6mu L of the control medicinal material solution, respectively applying the solutions to the same silica gel chromatographic sheet, taking a mixed solution of cyclohexane-ethyl acetate as a developing solvent, developing, taking out, drying in the air, and inspecting under a 365nm ultraviolet lamp. The identification method can be used for effectively removing impurities in a sample for test, the main ingredient loss is relatively small, and the chromatogram of the test-sample solution has clear and easily-distinguished spots, application of benzene and other reagent with relatively high toxicity can be avoided. The method has the advantages of high specificity, good repeatability, high sensitivity, environment friendliness and the like.

The invention provides a thin-layer chromatography identification method for Semen Persicae Preparata and its preparations, which is characterized by including the steps of a, preparing a control medicinal material solution, to be specific, taking Semen Persicae control medicinal material powder, adding sodium hydroxide solution, extracting, centrifuging, collecting supernate, adding chloroform for extracting, collecting lower extract and upper solution, extracting in the same way, combining the extracts, drying by evaporating, and adding methanol for dissolving to obtain the control medicinalmaterial solution; b, preparing a test article solution, to be specific, grinding a test article, and preparing the test article solution in the same way as the control medicinal material solution; c, measuring by thin-layer chromatography, to be specific, dropwise adding the control medicinal material solution and the test article solution to a same silica gel G plate, developing with cyclohexane-ethyl acetate as a developer, extracting, airing, spraying 10% ethanol sulfate solution, heating until spots are clear, and inspecting under an ultraviolet light. The method herein is suitable for quickly and effectively distinguishing Semen Persicae Preparata and its preparations, and Semen Persicae, Semen Persicae Preparata and their preparations. The method herein has good operational convenience, high precision, high sensitivity and good stability and has a good application prospect.

The invention relates to a water-soluble thermosetting acrylic resin and a preparation method thereof, belonging to the technical field of water-soluble thermosetting acrylic resin and a preparation method thereof. Including the following raw materials by weight: ethylene glycol monobutyl ether, isobutanol, isooctyl acrylate, n-butyl acrylate, hydroxypropyl acrylate, hydroxyethyl acrylate, styrene, methyl methacrylate, acrylic acid, propylene Acylmorpholine, 1,1-bis(tert-butylperoxy)cyclohexane, tert-butyl peroxybenzoate, isobutanol; additional charge 1: 1,1-bis(tert-butylperoxy)cyclohexane Alkane, butyl acetate; additional feed 2: 1,1‑bis(tert-butylperoxy)cyclohexane, butyl acetate; diluent: isobutanol. The resin of the present invention can easily solve the problems of water-based, firm adhesion, weather resistance and medium resistance of special acrylic baking coatings coated on special metal substrates (such as galvanized sheets, stainless steel, etc.).

The invention relates to a coated paper for an instant noodle cup lid and a preparation process thereof, and relates to the technical field of composite paper. The coated paper for an instant noodle cup lid comprises a base paper layer, a first coated layer and a second coated layer from bottom to top, An adhesive layer is provided between the first coating layer and the base paper layer, and the adhesive layer includes the following components in parts by weight: 40-60 parts of polyacrylate, 20-40 parts of epoxy resin, 10 parts of polyisobutylene ~30 parts and 3~5 parts of dibenzoyl peroxide, the adhesive layer also includes a solvent, the solvent includes ethyl acetate and cyclohexane, the amount of ethyl acetate is equal to the total amount of polyacrylate and epoxy resin, and the cyclohexane The amount of hexane is equal to the amount of polyisobutylene; the preparation process includes: S1. Adhesive layer preparation; S2. Second coating layer preparation; S3. Adhesive layer coating; S4. First coating; S5. Second coating ; S6. Post-processing. The invention solves the problem of poor adhesion between the PE layer and the base paper layer by arranging an adhesive layer between the PE layer and the base paper layer.