The invention discloses a
metal coordination polycation
gene vector. The
metal coordination polycation
gene vector consists of a coordinated
metal, a coordinated unit, a stimuli-responsive unit and polycations, and the structural general formula of the metal coordination polycation
gene vector is as shown in the specification, wherein M represents the coordinated metal; a dimethyl pyridylamine component represents the coordinated unit; a
disulfide bond component represents the stimuli-responsive unit; a ball represents the polycations; n represents the quantity of metal
ion ligands grafted by one polycation molecule, n is 1 to 200; and the metal coordination polycation
gene vector is used for non-
virus gene vectors. The metal coordination polycation
gene vector has the
advantage that the metal
ion ligands containing stimuli-responsive radicals are modified on the polycations, so that the
DNA binding capacity of the polycations and the acting force with cytomembranes are greatly improved; after the compound enters cells, the metal
ion ligands and the polycations are disconnected, DNAs are released and expressed so as to show extremely high
transfection efficiency, so that the application of the polycations in the aspect of the non-
virus gene vectors is greatly expanded due to metal coordination monomers in the invention.