The invention discloses an intelligent pure nano negative ion air purification device. The intelligent pure nano negative ion air purification device can be used for solving the problems that when a traditional nano air purification device is used, firstly, detaching and cleaning are inconvenient, secondarily, the intelligent degree is insufficient, even though the existing nano air purification device also has the function of automatic reminding performed when the interior of the existing nano air purification device needs to be cleaned, the existing nano air purification device does not havethe function of specifically showing that a certain portion of the interior of the existing nano air purification device needs to be cleaned, moreover, when cleaning is needed, the device needs to beintegrally detached so as to comprehensively clean the interior of the device, the operation is very troublesome. The intelligent pure nano negative ion air purification device comprises a machine box, an air outlet located on the side wall of one end of the machine box and an air inlet located on the side wall of the other end of the machine box, wherein the machine box is formed by sequentiallysplicing eight layers, namely, an air inlet layer, a fan layer, a macromolecular filter layer, a deodorization layer, an adhesion layer, a micromolecule filter layer, an outer layer and an exhaust layer, and penetrating holes are formed in the corners of the four edges of each of the air inlet layer, the fan layer, the macromolecular filter layer, the deodorization layer, the adhesion layer, themicromolecule filter layer, the outer layer and the exhaust layer.