31results about How to "No obvious stimulating effect" patented technology

The invention relates to rabeprazole sodium for injection as well as a preparation method and a detection method thereof. The rabeprazole sodium for injection is a medical preparation for injection, which is prepared from rabeprazole sodium as an active ingredient, a stabilizing agent, a pH value regulator and pharmaceutically acceptable auxiliary materials. The rabeprazole sodium for injection, disclosed by the invention, is rapid in effect taking and high in bioavailability, is used for treating gastrohelcosis, duodenal ulcer, erosive gastroesophageal reflux disease, helicobacter pylori injection, Zollinger-Ellision syndrome and the like and is more suitable for being used as a substitutive medicament when oral preparations for treating the diseases have no effect.

A liquid dressing for preventing the bacterial infection of skin wound by covering a film on the skin wound is prepared through high-temp reaction between methyl (and/or ethyl) methylacrylate and isooctyl acrylate to obtain a high-molecular polymer, and dissolving it in the polar solvent of ethyl acetate or the mixed solvent of ethyl acetate and n-hexane. Its advantages are air permeable and water-proof.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to application of herba dendrobii extractives for preparing a medicine capable of treating xerophthalmia. The invention also relates to a medicine used for treating the xerophthalmia. The herba dendrobii extractives can be applied in the medicine capable of treating the xerophthalmia. The medicine used for treating the xerophthalmia takes the herba dendrobii extractives as effective ingredients and comprises pharmaceutically acceptable carriers or auxiliary materials. The medicine can be prepared into any pharmaceutical dosage forms including injection preparation, oral preparation, mist spray preparation, ointment preparation, guttae ophthalmicae, patch and the like according to a common method for medicine preparation. According to the herba dendrobii extractives provided by the invention, the breakup time of a tear film is prolonged, and corneal injury is repaired so as to achieve a purpose on treating and preventing the xerophthalmia.

The invention discloses a production method of aroma-enhancing cigarette paper. The production method comprises the following steps: (1) mixing the following raw materials in parts by weight: 5-40 parts of honey, 10-30 parts of glycerin, 10-30 parts of alcohol and 1-5 parts of pectin; sufficiently emulsifying the mixture by a colloid mill to prepare a colloidal solution; and (2) printing the colloidal solution as printing ink on a paper base of the cigarette paper to obtain the cigarette paper with a honey aroma, wherein the use amount of the colloidal solution is 2-18g/m<2>. According to the aroma-enhancing cigarette paper disclosed by the invention, the aroma of the cigarette paper is increased, impure gas of the cigarette paper in a combustion process is alleviated and the smoking quality is improved.

The invention discloses a transdermal drug delivery system for treating infantile diarrhea. The transdermal drug delivery system consists of a substrate layer, a backing layer and a protective film; and the substrate layer comprises the following components in percentage by weight: 0.5 to 55 percent of gallnut extract, 5 to 60 percent of adhesive, 3 to 20 percent of organic solvent, 1 to 20 percent of plasticizer, 2 to 30 percent of thickening agent, and 1 to 10 percent of penetration enhancer. The substrate layer of the traditional Chinese medicine gallnut transdermal drug delivery system has high compatibility and adhesion with skin; the substrate layer has high stability; and the transdermal drug delivery system can be adhered to infantile Shenque acupoint (that is, navel), has the advantages of treating an inside disease outside the body of a patient, treating and preventing, avoiding injection and administration, being accepted by sick children and parents easily, along with simplicity, convenience and high operability.

The invention discloses a nano adjuvant of a poly(lactic acid-glycollic acid) covered immunologic stimulant and catalase. The nano adjuvant has a remarkable effect in radiotherapy and immunotherapy. The catalase can be used for effectively improving a tumor hypoxic microenvironment so that the radiotherapy effect is improved; meanwhile, the immunologic stimulant can be used for guiding the immunotherapy on a living body; the activity of regulatory T cells is inhibited, with the help of an immune checkpoint blocking agent; the immunologic stimulant has the effect of inhibiting tumor growth andmetastasis. The invention also discloses a preparation method and application of the nano adjuvant.

The invention relates to a traditional Chinese medicine for treating manus and tinea pedis, which adopts alum (dried alum), melanterite, saponin, polygonatum rhizome and cortex lycii radicis as drug raw materials, and is prepared by process steps of mixing, crushing, well mixing, sieving, sterilization, and packaging. The whole formula has excellent effect of clearing heat and drying damp, killing worm and relieving itching, killing fungi and relieving edema, and has significant effect on treating manus and tinea pedis, especially sweat herpes manus and tinea pedis caused by damp-heat retention.

The invention discloses diclofenac diethylamine emulgel. In the emulgel, isopropyl myristate, isopropyl alcohol and propylene glycol are combined as a penetration enhancer; carbomer 980 is used as a water-based gel substrate matrix; liquid paraffin is used as an oil-phase matrix; and polysorbate 80 and glycerol monostearate/distearate are used as emulsifiers. The diclofenac diethylamine emulgel disclosed by the invention is high in in-vitro penetration absorption speed, takes effect quickly, and is favorable for easing the pain of a patient in time; and moreover, the diclofenac diethylamine emulgel has the characteristics of less skin irritation and high stability.

The invention provides fullerene derivatives, the fullerene derivatives are fullerol represented by a formula of C60OxHy (x is less than 50 and more than or equal to y; y is more than 10 and less than or equal to x) or fullerene carboxyl derivatives represented by a formula of C60(C(COOH)2)n (n is an integer from 1 to 4), and the diameter range of nano particles of the fullerene derivatives in a solvent is from 1 to 400 nm. The invention also provides applications of a vaccine adjuvant of the fullerene derivatives in the vaccine field; the vaccine adjuvant has a good safety, can prominently improve the vaccine immunogenicity through different immunity ways, and has a very large application prospect.

The invention discloses an efficient antibacterial medical disinfectant fluid and a preparation method thereof. The disinfectant fluid is prepared from hydrogen peroxide, citric acid, deionized water,traditional Chinese medicine extracting solution, paracresylol soap, ethyl alcohol, lauryl alcohol polyoxyethylene ether, norfloxacin, sorbitol, potassium permanganate, dichlord isocyanurinate, and asterilizing agent according to the following ratio, by weight, 30-45 parts of hydrogen peroxide, 2-6 parts of citric acid, 100-150 parts of deionized water, 10-20 parts of traditional Chinese medicine extracting solution, 4-10 parts of paracresylol soap, 50-80 parts of ethyl alcohol, 3-7 parts of lauryl alcohol polyoxyethylene ether, and 2-6 parts of norfloxacin. On the basis of a conventional disinfection solution, a traditional Chinese medicine extracting solution, norfloxacin and a bactericide are added; according to the disinfectant fluid, the sterilizing effect of the disinfectant fluidcan be effectively improved, the added traditional Chinese medicine extracting solution is integrally prepared from traditional Chinese medicinal materials, the disinfectant fluid is prevented from being oxidized; meanwhile, the effect of no obvious stimulation to human skin is achieved, meanwhile, the pungent smell of existing disinfectant fluid can be covered to the maximum extent, and people can accept the disinfectant fluid more easily.

The invention relates to a method for nanocrystallization of small-molecule sheep placenta extract. The method comprises the step (1) of preparation of a solution A and a solution B, with a preparation method of the solution A comprising diluting a small-molecule sheep placenta extract stock solution with deionized water, adding a solution containing Ca<2+> with a concentration of 1 M to prepare a Ca<2+> solution with a concentration of 0.02-0.1 M, and standing at room temperature for 10-30 minutes to obtain the solution A, a preparation method of the solution B comprising the mixing a solution containing CO<3>< 2-> with a concentration of 0.02-0.1 M and a solution containing HPO<4><2-> with a concentration of 0.02-0.1 M, and uniformly shaking to obtain the solution B; and a step (2) of mixing the solution A and the solution B to obtain a small-molecule sheep placenta extract nano composite material with nanocrystallized micromolecular sheep placenta extract. The method is advanced and scientific, the prepared nano particles are smaller than 50 nm, good in dispersity and free of peculiar smell, the biological stability of the small-molecule sheep placenta is improved, the skin penetrating efficiency and biological activity of the small-molecule sheep placenta extract are improved, and the small-molecule sheep placenta extract nano material has no obvious stimulation effect on animal eyes and has good safety.

The invention discloses a peony whole plant extract-containing external-use therapeutic drug for treating hyperhidrosis and a preparation method thereof. The therapeutic drug for external use is composed of the following ingredients (by weight): 300-600 g of a peony whole plant extract, 100-200 g of radix ampelopsis, 100-200 g of rhizoma bletillae, 100-200 g of radix sophorae flavescentis, 100-200g of liquorice, 200-400 g of boric acid, 100-200 g of salicylic acid, 50-100 g of glycerinum, 50-100 g of hyaluronic acid, 50-100 g of butanediol, 20-40 g of Laurocapram, and 1000-2000 ml of 75% ethanol. The peony whole plant is prepared by mixing a peony bark extract, a peony flower extract and a peony leaf extract according to the mass ratio of 1: 1: 1. The therapeutic drug is used for treatinghyperhidrosis, dryness, roughness and chap and for anti-aging maintenance of the normal skin, and has the effects of moisturizing the skin and resisting inflammation, allergy, oxidation and aging.