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Liquor dressing of high polymer for preventing infection from breakage of skin

A high-molecular polymer and skin infection technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of limiting practical application value and high price of TRIS, and achieve the effect of reducing production costs and ensuring skin breathing

Inactive Publication Date: 2005-08-31
重庆工学院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the price of TRIS is extremely high, which limits the practical application value of this invention in China

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] A 250ml reaction kettle with precision electric stirrer (Jiangsu Jintan Ronghua Instrument Manufacturing Co., Ltd., JJ-1 type), condensing reflux and oil bath device was installed in a fume hood. Add 75.6g of methyl methacrylate, 6.6g of isooctyl acrylate and 118.0g of ethyl acetate into the reaction kettle; when the temperature rises to 50°C, add Vazo 67 60.99mg, constant temperature, turn on the electric stirrer, let it continue to stir and react at 60 rpm for 48 hours. After the reaction, the temperature of the reaction system was raised to 90° C., the reaction liquid was concentrated by distillation, and the concentrated reaction liquid was poured into 50 times the volume of distilled water for precipitation. After standing for 5 minutes, the viscous high molecular polymer floats on the water surface. The polymer was collected and dried in an oven at 65°C for 16 hours to obtain a colorless, viscous solid polymer. The solid polymer is dissolved in ethyl acetate po...

example 2

[0026] Change the reactor device in Example 1 into a 250ml reactor with precision electric stirrer, nitrogen inlet, condensing reflux and oil bath device (the following example 3-example 6 are the same). Add 69.5g of ethyl methacrylate, 15.0g of isooctyl acrylate and 134.2g of ethyl acetate into the reaction kettle, blow nitrogen into it for 1 to 2 minutes to remove the air; when the temperature rises to 55°C, add Vazo  67 67.73 mg, and then nitrogen gas was introduced for 1 to 2 minutes, the temperature was kept constant, the electric stirrer was turned on, and the stirring reaction was continued at 60 rpm for 36 hours. After the reaction, the temperature of the reaction system was raised to 80° C., the reaction liquid was concentrated by distillation, and the concentrated reaction liquid was poured into 50 times the volume of distilled water for precipitation. After standing for 10 minutes, the viscous polymer floated to the surface of the water. The viscous polymer was co...

example 3

[0028] Add 35.0g of methyl methacrylate, 35.0g of butyl methacrylate, 22.9g of decyl acrylate and 142.5g of ethyl acetate into the reaction kettle, and pass through nitrogen for 1 to 2 minutes to remove the air; when the temperature rises to 65 ℃, add Vazo  67 74.55mg, blow nitrogen again for 1 to 2 minutes to remove the air, keep the temperature constant, turn on the electric stirrer, let it continue to stir and react at 60 rpm for 24 hours. After the reaction, the temperature of the reaction system was raised to 85° C., the reaction liquid was concentrated by distillation, and the concentrated reaction liquid was poured into 50 times the volume of distilled water for precipitation. After standing for 30 minutes, the viscous polymer floated to the surface of the water. The polymer was collected and continuously dried in an oven at 65° C. for 24 hours to obtain a colorless, viscous solid polymer. The solid polymer is dissolved in ethyl acetate polar solvent at a ratio of 15...

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Abstract

A liquid dressing for preventing the bacterial infection of skin wound by covering a film on the skin wound is prepared through high-temp reaction between methyl (and / or ethyl) methylacrylate and isooctyl acrylate to obtain a high-molecular polymer, and dissolving it in the polar solvent of ethyl acetate or the mixed solvent of ethyl acetate and n-hexane. Its advantages are air permeable and water-proof.

Description

technical field [0001] The invention belongs to a medical material, in particular a high molecular polymer liquid dressing for preventing infection of damaged skin. When the solvent is volatilized, the thin film formed can cover the surface of the damaged skin, preventing external bacteria, water or other pollution sources from entering the damaged skin, thereby avoiding infection of the affected area and promoting wound healing. Background technique [0002] In people's daily life, skin injuries are very common, especially in children and those who often participate in outdoor sports activities, which can be manifested as skin abrasions, contusions, minor cuts, mosquito bites, minor burns, burns, crush injuries and other accidents or diseases cause. After the injury, the epidermis is damaged, and the wound surface is pale or red, with bleeding and interstitial fluid exudation, often accompanied by infection and scarring in the later stage. The usua...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/24
Inventor 姜和苏小运黎俊伯
Owner 重庆工学院
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