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Application of herba dendrobii extractives for preparing medicine capable of treating xerophthalmia, and medicine

A technology of dendrobium extract and dry eye syndrome, applied in drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problem of dry eye syndrome that has not yet been found in the application of a single herb of dendrobium

Inactive Publication Date: 2017-04-26
CHINA TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it is only seen that Dendrobium has certain applications in the form of Chinese herbal medicine compound in eyesight protection, such as: for the treatment of cataracts, etc., but the application of single herb Dendrobium or its extracts in the prevention and treatment of dry eye has not been found.

Method used

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  • Application of herba dendrobii extractives for preparing medicine capable of treating xerophthalmia, and medicine
  • Application of herba dendrobii extractives for preparing medicine capable of treating xerophthalmia, and medicine
  • Application of herba dendrobii extractives for preparing medicine capable of treating xerophthalmia, and medicine

Examples

Experimental program
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preparation example Construction

[0038] One, the preparation of dendrobium extract of the present invention

[0039] In order to facilitate understanding, memory and examiner's review, each Dendrobium extract in this article is uniformly marked with the following symbols:

[0040] 1-A: Alcoholic extract of Dendrobium officinale;

[0041] 1-B: Chloroform extraction part of the ethanol extract of Dendrobium officinale;

[0042] 1-C: Ethyl acetate extraction part of the ethanol extract of Dendrobium officinale;

[0043] 1-D: the n-butanol extraction part of Dendrobium candidum ethanol extract;

[0044] 1-E: the water part after extraction of Dendrobium candidum ethanol extract;

[0045] 1-F: The part where the secondary extract of Dendrobium officinale alcoholic extract was concentrated under reduced pressure and combined with the first extract;

[0046] 1-G: the polysaccharide part of Dendrobium officinale;

[0047] 2-A: Extract juice from Dendrobium nobile;

[0048] 2-B: alcohol extract of Dendrobium nob...

Embodiment 1

[0212] Take 800g of clean and fresh Dendrobium officinale and cut it off, crush it with a juice extractor, and then extract it twice with 8L (10 times the amount) of 80% ethanol under reflux, each time for 1.5 hours, combine the filtrates, and concentrate at 50°C to 60°C to relative The brown viscous extract with a density of 1.10 was concentrated and dried under reduced pressure at 55° C. for 12 hours to obtain about 35 g of powdery dendrobium extract, with a yield of 4.4%. The dendrobium extract, sodium hydroxide and water are prepared into eye drops. The sum of the mass of sodium hydroxide and water is 1 to 10 times of the mass of dendrobium extract.

Embodiment 2

[0214] Take 800g of clean and fresh dendrobium and cut it off, smash it with a juicer, and extract it with 4L (5 times the amount) of 30% ethanol under reflux for 3 times, each time for 1 hour, combine the filtrates, and concentrate at 50°C to 60°C to a liquid medicine The brown viscous extract with a relative density of 1.15 was dried under reduced pressure at 50° C. for 10 hours to obtain about 32 g of powdered Dendrobium officinale alcohol extract, with a yield of 4.0%. The ethanol extract of Dendrobium officinale, 5% glucose and water are prepared into eye drops. The sum of the mass of 5% glucose and water is 10-20 times that of the dendrobium officinale alcohol extract.

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to application of herba dendrobii extractives for preparing a medicine capable of treating xerophthalmia. The invention also relates to a medicine used for treating the xerophthalmia. The herba dendrobii extractives can be applied in the medicine capable of treating the xerophthalmia. The medicine used for treating the xerophthalmia takes the herba dendrobii extractives as effective ingredients and comprises pharmaceutically acceptable carriers or auxiliary materials. The medicine can be prepared into any pharmaceutical dosage forms including injection preparation, oral preparation, mist spray preparation, ointment preparation, guttae ophthalmicae, patch and the like according to a common method for medicine preparation. According to the herba dendrobii extractives provided by the invention, the breakup time of a tear film is prolonged, and corneal injury is repaired so as to achieve a purpose on treating and preventing the xerophthalmia.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to the application of a dendrobium extract in preparing a medicine for treating dry eye, and also relates to a medicine for treating dry eye, especially a medicine whose active ingredient is a dendrobium extract. It also relates to an eye drop whose active ingredient is dendrobium extract and which is used for treating dry eye. Background technique [0002] Dry eye is a series of syndromes caused by the imbalance of tear quality and quantity after the secretion of water quality, mucus and lipid on the surface of the eyeball due to various reasons, or a tear and ocular surface disease caused by multiple factors , including symptoms of ocular surface discomfort, vision changes, and tear film instability with underlying ocular surface damage, accompanied by increased tear osmolarity and ocular surface inflammation, is a tear film instability caused by abnormalities in the quan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61K9/08A61K47/02A61K47/26A61K47/14A61K47/18A61P27/02
CPCA61K9/0048A61K9/08A61K36/8984A61K47/02A61K47/14A61K47/183A61K47/26A61K2236/333A61K2236/39
Inventor 刘莉吴彤梅其炳兰青山王继永顾丰华胡晓肖苏萍赵雁
Owner CHINA TRADITIONAL CHINESE MEDICINE
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