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Application of tromethamine acetate in physical fatigue resistance

A tromethamine acetate and antibody technology, applied in the direction of antidote, drug combination, etc., can solve the problem of unknown anti-fatigue effect, and achieve the effect of reducing the impact on the body and improving exercise endurance.

Inactive Publication Date: 2018-02-23
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Tromethamine acetate has been found to alkalinize urine, promote uric acid excretion and protect renal function, but whether it has anti-fatigue effect is unknown, and there is no relevant literature report

Method used

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  • Application of tromethamine acetate in physical fatigue resistance
  • Application of tromethamine acetate in physical fatigue resistance
  • Application of tromethamine acetate in physical fatigue resistance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 Acetate tromethamine enhances swimming ability of mice

[0017] Take 250ml of physiological saline for injection as A solution. Get sodium bicarbonate (molecular weight 84.01) 3.64g, dissolve into 250ml distilled water, measure solution pH with pH meter and be 8.16, this solution is B solution. Take 3.56g of sodium acetate (molecular weight 82.03), add distilled water to dissolve, measure the pH, add 5% acetic acid or 1M sodium hydroxide to adjust the pH to 8.10-8.20, and dilute to 250ml. This solution is C solution. Take tromethamine (molecular weight: 121.1) 5.25g and add distilled water to dissolve, titrate to pH 8.10-8.20 with glacial acetic acid or 5% acetic acid solution, and set the volume to 250ml, this solution is D solution. Take tromethamine (molecular weight: 121.1) 5.25g and add distilled water to dissolve, titrate to pH 8.10-8.20 with concentrated hydrochloric acid or dilute hydrochloric acid solution, and dilute to 250ml, this solution is E ...

Embodiment 2

[0026] Example 2 Different doses of tromethamine acetate enhance the swimming ability of mice

[0027] Take 250ml of physiological saline for injection as A solution. Get tromethamine (molecular weight 121.1) 5.25g, add distilled water to dissolve, titrate to pH 8.10-8.20 with glacial acetic acid or 5% acetic acid solution, settle to 250ml, this solution is D-high solution (high dose). Dilute D-high solution twice to get D-medium solution (medium dose). Dilute the D-medium solution again to obtain D-low solution (low dose). The concentration of each solution is shown in Table 3.

[0028] Table 3: Concentrations of five solutions

[0029]

[0030]

[0031] Note: The solutes of tromethamine hydrochloride and tromethamine acetate are calculated as tromethamine.

[0032] 100 male Kunming mice, weighing 18-22 g, were randomly divided into 4 groups, namely A, D-high, D-middle and D-low groups, 20 in each group (see Table 4 for grouping). After 2 days of adaptive feeding, ...

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PUM

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Abstract

The invention discloses the application of tromethamine acetate in physical fatigue resistance. The tromethamine acetate is orally taken, and the used adult dosage is less than 3 g (based on tromethamine) every day. Organic acid salt uses aminotriol acetate as organic base, organic acid, namely acetic acid, is easily metabolized by the human body and intestinal bacteria, and the released organic base can pass through cytomembranes and various acids generated by strenuous exercises and has the effect of resisting physical fatigue.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to the application of tromethamine acetate in antibody-type fatigue. Background technique [0002] With the acceleration of the pace of life, work overload and dealing with some idiosyncratic events, fatigue has become a common event for some people. While prolonged fatigue is detrimental to physical and mental health, short periods of fatigue are sometimes unavoidable. Overcoming fatigue and completing predetermined tasks are the needs of specific situations. [0003] Fatigue can be roughly divided into two types, one is mental fatigue, which is characterized by inability to concentrate on completing certain things, and generally does not consume much physical energy, such as fatigue driving. The other is physical fatigue, that is, even if you have energy, you cannot complete the corresponding physical work due to the "back pain" caused by long-term muscle work. This is more com...

Claims

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Application Information

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IPC IPC(8): A61K31/133A61P39/00
Inventor 段为钢董鲜祥云宇张路梅殷华吕小满杨榕
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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