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Liquid wound dressing for rapidly repairing skin superficial injury, and preparation method thereof

A technology for wound dressing and superficial injuries, applied in medical science, bandages, etc., can solve problems such as warping, turbidity, and easy cracking of the film

Active Publication Date: 2021-07-30
多能干细胞再生医学科技(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The film-forming time of liquid dressings in the prior art is usually within five minutes, among which, the film-forming speed of nitrocellulose-based liquid dressings is the fastest, and can be film-forming in 30 seconds, which means that the film can be formed in a very short time. Wound coverage, but nitrocellulose-based liquid dressings have shortcomings such as strong skin tightness, easy cracking of the film layer, warping around the film, short waterproof period, and turbidity when encountering liquid in the wound.

Method used

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  • Liquid wound dressing for rapidly repairing skin superficial injury, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1)

[0029] A preparation method for a liquid wound dressing that promotes rapid repair of skin damage, the formula of which is as follows:

[0030] Cytokines 1mg

[0031] Polyvinyl butyral 1g

[0032] N-(Alkylthiopropylene)dimethylbetaine 1g

[0033] Polyacrylic acid 3g

[0034] Appropriate amount of pH adjuster

[0035] Deionized water 50g

[0036] Its preparation steps are as follows:

[0037] 1. Preparation of solution A: add 70% deionized water in the preparation tank, add N-(alkylthiopropylene) dimethyl betaine, add polyvinyl butyral after dissolving, Stir for 10-20min to obtain solution A;

[0038] 2. Preparation of solution B: Dissolve polyacrylic acid in the remaining deionized water, and stir for 15-20 minutes to obtain solution B;

[0039] 3. Preparation of solution C: Mix solution A and solution B, homogenize at high speed for 5-7 minutes until the whole system has no granular solid components, add cytokine PDGF-BB, cool to room temperature, adjust ...

Embodiment 2

[0042] Same as Example 1, except that N-dodecyl-N,N-dimethyl-N-carboxymethyl betaine is used instead of N-(alkylthiopropylene) dimethyl betaine.

Embodiment 3

[0047] Embodiment 3: safety test

[0048] The liquid wound dressing of embodiment 1-2, comparative example 1-2 is carried out animal skin irritation test, skin sensitization test, in vitro cytotoxicity test respectively, and the result shows that embodiment 1-2 and comparative example 1 are safe and nontoxic, and Comparative Example 2 caused skin redness and swelling of the animal.

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Abstract

The invention relates to a liquid wound dressing for rapidly repairing skin superficial injury, and a preparation method thereof. The liquid wound dressing is prepared from cell factors PDGF-BB, polyvinyl butyral, a betaine type surfactant, polyacrylic acid and deionized water. The liquid wound dressing provided by the invention can form a waterproof, breathable and antibacterial protective film on the surface of a wound, plays a physical barrier role, prevents bacteria and foreign matters from invading the wound, and creates a wound healing environment; and after being smeared, the ointment has the effects of protecting new tissues and accelerating wound healing.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a liquid wound dressing for rapid repair of superficial skin damage and a preparation method thereof. Background technique [0002] Since it is inevitable to encounter wounds caused by cuts, abrasions, bruises, falls and contusions in daily life, necessary treatment of wounds is required in many cases, such as wound debridement and hemostasis And apply a medical dressing to the wound. [0003] In recent years, with the remarkable improvement of family self-care awareness, ordinary people’s homes are usually equipped with various routine care products such as band-aids, iodophors, alcohol sprayers, medical cotton balls or swabs, cameras, thermometers, blood pressure monitors, blood sugar monitors, etc. instruments, various test papers, etc. The above-mentioned wound paste is a wound dressing, because it is suitable for self-treatment of mild small wounds or family...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0066A61L26/0014A61L26/0061A61L26/0004A61L2300/412A61L2300/404A61L2300/414C08L29/04C08L33/02
Inventor 顾军兰丹黄力越顾帅
Owner 多能干细胞再生医学科技(广州)有限公司
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