58results about How to "No inhibitory effect" patented technology

The invention belongs to the field of Chinese traditional medicines and relates to a new use of 8-0-4' lignan in preparing an anti-complement medicine. The compound 8-0-4' lignan is extracted from a Chinese medicinal herb eucommia bark, and in vitro experiments prove that the compound 8-0-4' lignan can inhibit cell hemolysis caused by the activations of classical and alternative pathways of a complement system, and has obvious inhibitory action on the activation of the classical and alternative pathways of the complement system; and the results of pharmacological tests prove that the compound 8-0-4' lignan has obvious anti-complement effect and low effective concentration. The compound 8-0-4' lignan of the invention can be further taken as an active ingredient for preparing a novel anti-complement medicine.

The invention discloses a photocureable silicon nitride ceramic paste and a preparation method thereof. According to the invention, stearic acid powder and a premixed solution are additionally used asraw materials on the basis of ceramic powder, wherein the premixed solution is composed of a plurality of substances. According to the invention, through addition of the stearic acid powder, the compatibility of the ceramic powder and subsequent resin can be improved, and the solid phase content of silicon nitride ceramic can be easily improved; through optimized selection of all substances in the premixed solution, resin with high refractive index can be introduced into a resin system to reduce the difference of refractive indexes of the ceramic powder and the resin, so the single-layer curing depth of a ceramic paste can be improved; in addition, rigid group containing epoxy resin, isobornyl methacrylate (IBOMA) and the like are added into the resin to reduce shrinkage generated in theprocess of curing; and through optimization of the varieties of all substances, the photocureable ceramic paste provided by the invention has the following advantages: the solid phase content and single-layer curing depth of the isobornyl methacrylate are improved, and the shrinkage amount of the paste photocured into ceramic is reduced.

This invention relates to three-spiral lentina with beta-(1-3)-D-glucan having 20-30%(1-6) chain connected glucose side chains as main chain. It shows three chains in water, with average molecular weight of 20,000-200,000. It is produced by: cutting dry shiitake, removing fat by Suo extraction, soaking in normal saline, centrifuging, extracting remains at 100-130 degrees C, centrifuging, extracting remains in water solution of NaOH / NaBH4, adding acetic acid into extracting liquid to neutralize, decoloring supernatant, removing free protein, dialyzing, concentrating, and frozen drying. It has higher anti-tumor activity and can be used to prepare medicines or health-care products for improving immune ability and antitumor.

The invention discloses an application of polypeptide in preparing preparations for preventing and treating human papilloma virus infection, and belongs to the field of infectious disease treatment. Apolypeptide preparation for preventing and treating human papilloma virus infection is also provided; and the polypeptide preparation takes the polypeptide with effective dose as active ingredients and is prepared by adding pharmaceutically acceptable subsidiary materials or auxiliary components. The polypeptide can be used for the treatment and prevention of human papilloma virus infection, so that the polypeptide is significant in effect; and the polypeptide has no inhibition effects on the normal flora of female genital tracts, so that the polypeptide is good in safety.

The invention discloses an ozone electrolysis chamber electrolysis structure. The ozone electrolysis chamber electrolysis structure comprises a cathode sheet, an anode sheet and a membrane arranged between the cathode sheet and the anode sheet. One side face of the membrane is parallel and opposite to the side face of the cathode sheet, the other side face of the membrane is parallel and oppositeto the side face of the anode sheet, and the surfaces / the surface of the cathode sheet and / or the anode sheet are / is provided with through holes. The through holes formed in the cathode sheet and theanode sheet are staggered, and axial projections are not overlapped. Through holes formed in the surface of the membrane are axially opposite to the through holes formed in the surface of cathode sheet or the anode sheet. The cathode sheet and the anode sheet are electrically connected through water flowing through the cathode sheet and the anode sheet. Compared with the prior art, the technical scheme has the advantages that the structure is simple, and disinfection is efficient; and the purposes that the ozone water electrolytic tank manufacturing cost is reduced, and the ozone water generation efficiency and sterilization purification capability are improved can be effectively achieved.

The invention relates to a pharmaceutical composition containing an FGFR4 inhibitor, in particular to the pharmaceutical composition containing the FGFR4 inhibitor with a structure shown in a formula(I). The pharmaceutical composition developed by the invention has strong inhibition effect on FGFR4 kinase activity, and can be widely used for preparing medicaments for treating cancers, especiallyliver cancer, gastric cancer, prostate cancer, skin cancer, ovarian cancer, lung cancer, breast cancer, colon cancer, pancreatic cancer, esophageal cancer, glioma or rhabdomyosarcoma. (See the instruction for specific formula).

The invention discloses application of an antigen containing 6-N-methyllysine residue in preparation of reagents or kits for auxiliary diagnosis of systemic lupus erythematosus. Experiments of the invention prove that human IgM can identify 6-N-methyllysine, and can be combined with arbitrary peptide or protein containing 6-N-methyllysine residue, 6-N-methyllysine has an inhibitory effect on IgM identifying 6-N-methyllysine, but non-methylation modified lysine has no inhibitory effect, most healthy people have a high level of the IgM antibody, and the level of the IgM antibody is significantly reduced in patients with systemic lupus erythematosus. The antigen containing 6-N-methyllysine residue can be used for preparation of reagents or kits for auxiliary diagnosis or screening of systemic lupus erythematosus.

The invention relates to a composite lysozyme oral spray and a preparation method thereof. The composite lysozyme oral spray is remarkable in effect and convenient to use, and does not contain alcohol; all components are extracted from natural products, enable fresh breath after used and do not have toxic or side effect under combined action of lysozyme, tea polyphenol and vitamin C; the oral spray has good prevention and treatment effects to dental ulcer, decsyed teeth, aphtha, ozostomia, glossitis, sphagitis and other dental diseases; the preparation method is concise and effect, and low in cost; the prepared composite lysozyme oral spray is good in stability.

The invention discloses a peanut seed dressing agent as well as a preparation method and an application method thereof and aims to solve the technical problems of high toxicity, high probability of chemical damage, unavailable raw material and high cost of the conventional peanut seed dressing agent. The peanut seed dressing agent is prepared from raw materials in parts by weight as follows: garlic clove filtrate, 5-10 parts of Sichuan pepper, 8-10 parts of pepper, 5-8 parts of clove, 5-10 parts of tsaoko amomum fruit, 5-10 parts of anise, 3-5 parts of cinnamon and 0.05-0.8 parts of plant growth regulator, wherein the dosage of the garlic clove filtrate is 1-3 times the total mass of the other raw materials. The peanut seed dressing agent is plant-sourced, can integrate an insect expelling effect, an insecticidal effect and a disinfecting effect, has remarkable preventing effect on common pest and disease damage of peanuts without affecting emergence and growth of the peanuts, has long duration, is non-toxic, residue-free and pollution-free to environment and meets production regulations of agricultural safety food, and disease-resistant and insect-preventing measures are not needed in late period after seed dressing.

The invention relates to a composite lysozyme oral spray. The oral spray is characterized by comprising the following components in percentage by weight: 3-7 percent of lysostaphin, 20-25 percent of lysozyme, 0.02-0.4 percent of tea polyphenol, 1.5-5 percent of olive oil, 1-10 percent of vitamin C, 1-3 percent of sorbitol, 0.8-2 percent of lecithin, 0.01-0.07 percent of xanthan gum, and the balance of purified water. The oral spray is remarkable in effects and convenient to use, and does not contain alcohol; all components are extracted from natural products, and enable fresh breath and no toxic or side effect in the action of compatibility of composite lysozyme, tea polyphenol and vitamin C. The composite lysozyme oral spray has good preventing and treating effects on dental ulcer, decayed teeth, aphtha, halitosis, glossitis, sphagitis and other oral diseases; the preparation method is concise and effective and low in cost, and the prepared composite lysozyme oral spray is good in stability.

The invention discloses an integrated wastewater treatment device. The integrated wastewater treatment device comprises an upward flow type reactor, an ozone reactor (7), a water tank (1) and a Venturi tube (8). The reactor sequentially comprises a denitrification region (3), a catalytic ozonation region (4) and a biological aerated filter (5) from bottom to top. A water inlet (18) is formed in the bottom of the denitrification region (3), and a water outlet (10) is formed in the top of the reactor. A first backflow opening (16) and a second backflow opening (17) are formed in the upper portion of the reactor, and the water inlet (18) is connected with the water tank (1) through a first pipeline (13) and connected with the first backflow opening (16) through a second pipeline (14). The invention further discloses a method for treating petrochemical wastewater through the integrated wastewater treatment device. The good organic matter and total nitrogen removal effect is achieved while the petrochemical wastewater is deeply treated.

The invention relates to a bacterial strain CH18 capable of generating anthocyanidin and an application thereof, which belong to the technical field of microbe. The bacterial strain CH18 through identification is Fusarium oxysporum, and a preservation number is CGMCC NO.14784. The bacterial strain has the advantages of wide adapting scope and easy culture, and can use agricultural solid waste, a grain raw material and a plurality of mediums to generate anthocyanidin through fermentation, and has the advantages of simple process, low cost, short production period, high anthocyanidin output, andwhole year production. The bacterial strain CH18 and its fermentation product have no biological toxicity, and is green and environmentally friendly. The anthocyanidin can be widely used for the fields of medical treatment, food, cosmetic, hair protection, and dental caries prevention, and has wide application prospect.

The invention provides a method of growing of grapes by the effective reduction of cadmium accumulation and the complying of steady output, belongs to the technical field of crop cultivation. The method of hybrid growing of wild crowndaisy chrysanthemum and grapes is adopted for the grape-growing soil. A hybrid method of growing grapes by efficient management of the pollution of cadmium to grape is ascertained, and a method of growing of grapes by not producing inhibition effect on biomass fundamentally and the good complying of steady output is found, the pollution problem of heavy metal cadmium in the grape is effectively solved, and the stable output of grapes is guaranteed, and the economic interests of the grape growers are well preserved.

The invention discloses a traditional Chinese medicinal compound preparation for treating heart heat internal disturbance type night cry, and a preparation method and an application thereof. The preparation comprises, by weight, 2-40 parts of honeysuckle flower, 2-40 parts of Rhizoma Coptidis and 2-40 parts of common rush. Above components can be respectively extracted and then mixed, and can also be mixed and then extracted; an extraction solvent can be water or 10-95% ethanol; and an extraction method is a routine traditional Chinese medicine extraction method. The above medicinal composition prepared in the invention can be processed through routine methods to prepare various oral preparations used for treating heart heat internal disturbance type night cry. The traditional Chinese medicinal compound preparation for treating heart heat internal disturbance type night cry can clear heat and detoxify, and is used for reducing heart heat, dispelling fetal toxicity, dispel blood stasis, and treating upset, insomnia and children's night cry.

The invention provides an N2-carbamylaryl-2-aminopyrimidine derivative and a medical application thereof. The N2-carbamylaryl-2-aminopyrimidine derivative provided by the invention comprises an optical isomer of the N2-carbamylaryl-2-aminopyrimidine derivative and pharmaceutically acceptable salt thereof. Pharmacodynamic research shows that the traditional Chinese medicine composition has no toxicor side effect, the compound has an FLT3 inhibitory activity. The proliferation inhibition activity is realized on various leukemia cell strains; a medium inhibition effect is achieved on breast cancer cells; moreover, the polypeptide is effective for multiple mutations of AML, such as internal tandem repeat mutation of a near-membrane structural domain and D835 point mutation of an activated ring in a kinase structural domain, almost has no inhibition effect on c-KIT, can overcome drug resistance brought by clinical point mutation, can reduce toxic and side effects of bone marrow inhibition,and can be applied to preparation of antitumor drugs. The structures of the general formulas Ia and Ib of the N2-carbamylaryl-2-aminopyrimidine derivative are shown in the specification,

The invention discloses a preparation method and an application of uracil DNA glycosidase. The uracil DNA glycosidase prepared by using the method can be used for hydrolyze glucosidic bonds between uracil basic groups and deoxyriboses in DNA at the temperature of 20-37 DEG C; at the same time the glycosidase has a good heat sensitivity, when the temperature is higher than 60 DEG C, the glycosidase swiftly loses activeness, when the temperature reaches 60 DEG C for 5 minutes, the enzymatic activity loses by 99%; the prepared heat sensitive uracil DNA glycosidase can be used for preventing the sample DNA contamination in all types of nucleic acid detection reaction. The preparation method and application of uracil DNA glycosidase have the advantages being capable of both completely removing the contaminated DNA, and exerting no inhibition to the nucleic acid amplified reaction. The glycosidase can be used as a cleaning agent to the sample contamination in all types of nucleic acid amplified reaction (such as PCR), can remove the DNA contamination caused by the products of the previous amplified reaction, and increase the accuracy of nucleic acid test.

The invention provides a biological drainage treatment device. The biological drainage treatment device comprises a device body provided with a filter unit. The device body comprises a frame provided with an accommodating cavity. The filter unit is arranged in the accommodating cavity. The filter unit includes a first filter unit filled with volcanic-rock filter materials. The biological drainage treatment device has the advantages that the defect that a traditional biological treatment device is low in pollution load is overcome; the first filter unit is filled with the volcanic-rock filter materials which are good in a biochemical stability, resistant to corrosion, high in absorption quantity and fast in absorption; aquatic plants planted on a second filter unit, algae in a third filter unit and a microbial-symbiosis biological dynamic regulating system in a fourth unit allow the plants and microorganisms to be coordinated, sewage purification load capacity is strengthened, and the biological drainage treatment device is high in industrial value.

The present invention relates to non-competitive allosteric peptide inhibitors of DPP9 and / or DPP8, competitive peptides binding to SUMO1, nucleic acid molecules and expression vectors coding said peptide inhibitors, host cells expressing said inhibitors, kits comprising said inhibitors, as well as methods of producing said inhibitors, and uses of said peptide inhibitors; as further defined in the Claims.

The invention provides a magnesite powder briquetting binding agent as well as a preparation method and application thereof. The magnesite powder briquetting binding agent is prepared from the following components in parts by weight: 3-6 parts of a dispersing agent, 2-8 parts of a surfactant, 3-6 parts of a defoaming agent, 4-10 parts of a binding agent, 4-8 parts of a demoulding agent, 35-45 parts of an auxiliary reagent capable of promoting mutual solution and 20-50 parts of water. The invention also discloses a preparation method of the magnesite powder briquetting binding agent. The preparation method of the magnesite powder briquetting binding agent comprises the following steps: mixing the components in parts by weight at the temperature of 70-100 DEG C, and dissolving to obtain the magnesite powder briquetting binding agent. The invention also discloses application of the magnesite powder briquetting binding agent in magnesite powder briquetting. The magnesite powder briquetting binding agent is scientific and reasonable in formula, magnesite powder briquetting can be completed by adopting the magnesite powder briquetting binding agent only, and magnesite pellets prepared by adopting the magnesite powder briquetting binding agent are ideal in appearance and uniform in material.

The invention discloses antibacterial gel for restoring female ecological balance and a preparation method thereof, and relates to the technical field of antibacterial drugs. The antibacterial gel ismainly prepared from an antibacterial raw material. The antibacterial raw material comprises an ecological balance liquid and a plant extract. The ecological balance liquid comprises the following rawmaterials in parts by weight: 4.5-5.5 parts of acetyl heptapeptide-4, 0.3-0.8 part of recombinant human collagen, 12-25 parts of plant active polysaccharide, 15-25 parts of plant active ingredients and 10-12 parts of purified water. The antibacterial raw material further comprises the following raw materials in parts by weight: 0.05-0.1 part of benzalkonium bromide, 0.8-1.5 parts of a pH regulator, 1-3 parts of a gel matrix and 30-32 parts of purified water. The antibacterial gel for restoring the female ecological balance has the advantage of good treatment effect. The preparation method comprises the following steps of dissolving, plant extracting, swelling, diluting, gelling and the like. The preparation method of the antibacterial gel for restoring the female ecological balance has the advantage that the treatment effect of a product can be improved.

The invention discloses a sewage treatment method for inhibiting nitrifying bacteria and enhancing nitrogen and phosphorus removal efficiency, and belongs to the technical field of environmental engineering. For an SBR (sequencing batch reactor) running in an anaerobic / micro-aerobic / anoxic mode, hydroxylamine hydrochloride is added in the initial aeration period of a plurality of running periods in each day for a plurality of days continuously, so that whole-course nitrification is promoted to be converted into short-cut nitrification. The method can effectively improve the removal rate of total nitrogen and total phosphorus in the effluent. Hydroxylamine hydrochloride is added, so that whole-course nitrification can be promoted to be converted into short-cut nitrification, the phosphorusaccumulation effect of PAO (phosphorus accumulation bacteria) can be improved, meanwhile, the activity of AOB (ammonia oxidizing bacteria) can be promoted, the ammonia oxidation completion time can beshortened, the anoxic period time can be prolonged under the condition that the operation period is not changed, and the total nitrogen removal rate can be increased; moroever, the input quantity ofa carbon source also can be reduced. Compared with the conventional denitrification nitrogen and phosphorus removal method by adding the carbon source, the denitrification nitrogen and phosphorus removal method has economic advantages and has the advantage of reducing the sludge yield.

The invention provides a synergistic bactericide composition, and a preparation method and application thereof. The effective medicinal components of the composition consist of polyoxins and glucan glycal, wherein the weight ratio of the polyoxins to the glucan glycal is (5-10):(0.1-5); the synergistic bactericide composition is prepared by a mixing mode and can be applied to preparation of pesticide for preventing and treating alternaria leaf spot; and the polyoxins and the glucan glycal in the composition are compounded according to the specific proportion and are synergistic, so the effect of preventing and treating alternaria leaf spot of apple trees and the like is remarkable.

The invention provides a freeze-drying protective additive, a fluorescent PCR detection kit and a freeze-drying process, wherein the freeze-drying protective additive is used for freeze-drying a fluorescent PCR reagent, and the freeze-drying protective additive comprises the following components: trehalose, hydroxyethyl starch and Tween 20. According to the freeze-drying protective agent, the trehalose, the hydroxyethyl starch and the Tween 20 are adopted, so that the active conformation of protein is maintained in the freeze-drying process, the freeze-drying protective agent has a proper glass transition temperature, the protein is well protected in the freezing and dehydration processes, and the inhibition effect on PCR is avoided. The freeze-drying protective agent can be applied to freeze-drying of fluorescent PCR reagents of different manufacturers, and the product is high in universality and has no inhibition effect on the performance of the fluorescent PCR reagents.

The invention discloses enterococcus faecium, application and composition thereof and a fermentation culture method of the enterococcus faecium, the name of the enterococcus faecium is HSC-18, the classification name is Enterococcus faecium, the preservation number is CCTCC NO: M 20211446, the preservation date is November 18, 2021, the preservation unit is China Center for Type Culture Collection, the preservation number is CGMCC NO: M 20211446, and the preservation number is CGMCC NO: M 20211446. The enterococcus faecium can be used for preparing feed additives, animal feed, food additives, food or probiotics. The active component of the composition comprises enterococcus faecium HSC-18, and the composition is a feed additive, an animal feed, a food additive, food or a probiotic agent. The fermentation culture method of the enterococcus faecium comprises the following steps: inoculating the enterococcus faecium into an enterococcus faecium fermentation culture medium, and carrying out fermentation culture for 10-20 hours under the conditions that the temperature is 35-40 DEG C and the pH value is 5.8-7.0.

The invention discloses a porous fiber material carrier and a preparation method thereof. A fiber material is put in water for cleaning and then is put in ethyl alcohol for soaking, then thorough flushing is performed with ethyl alcohol, the fiber material is dried, smashed and mixed and then is added into a 3D printer for heating and melting, a carrier digital model file is used as a basis, a 3D printing technology is applied to prepare the carrier in a layer-by-layer printing mode. The invention also discloses application of an anaerobic expanded granular sludge bed added with the porous fiber material carrier in treatment of ethyl alcohol waste water. The reactor operation is stable in the starting process of a reactor, the problem of sudden acidification does not occur, the starting time is obviously shortened, the sludge amount in effluent is obviously decreased, the effluent is approximately clarified, and accordingly later discharge treatment is promoted.

The invention is applicable to the field of analytical instruments, and provides a sampling and sample introduction multifunctional probe for liquid mass spectrometry electrospray, which comprises a probe body and a tip part, the tip part is formed by continuous contraction of the whole or part of the probe body, and the tip part is provided with a solution carrying structure. The invention further provides a liquid phase mass spectrum sampling and electrospray combined device comprising the multifunctional probe. The liquid phase mass spectrum sampling and electrospray combined device comprises a sample injection mechanical arm, a sample injection needle seat and an ion source sealing cavity. The ion source provided by the invention is also a sampling needle, has the characteristics of small sampling amount (about 0.1-10mu L) and high needle washing speed, and compared with the traditional sample injection mode, a needle pump and a sample injection valve are omitted, so that the stability and the detection sensitivity are greatly improved.

The invention discloses a wormwood antibacterial agent and a preparation method thereof. The preparation method of the wormwood antibacterial agent includes the steps: pretreating wormwoods to obtainwormwood extracts; heating, mixing and cooling the wormwood extracts and salicylic acid; adding boric acid and benzoic acid, mixing, stirring, standing and sub-packaging the materials to obtain the wormwood antibacterial agent. The preparation method of the wormwood antibacterial agent is simple, low in cost, free from irritation and toxic and side effects, suitable for large-scale production andwide in application prospect. The wormwood antibacterial agent is free from any toxic and harmful chemical components, toxic and side effects, chemical residues and any toxicity, low in cost, non-irritating to human bodies and good in stability, can be used and preserved for a long time, has high antibacterial properties and also has sterilization and bacteriostasis functions.

The invention provides an application of acetylacetone in inhibiting growth of blue-green algae. Acetylacetone is added into a blue-green algae growth water area, and the adding amount is not less than 7mg / L, so that the growth of the blue-green algae is controlled; acetylacetone acts on a photosynthetic system to control the growth of algae, the effect of acetylacetone is superior to that of a common algistat (such as pyrogallic acid, gallic acid and anthraquinone), acetylacetone is harmless to bacteria including four common bacteria including escherichia coli, salmonella, bacillus subtilis and staphylococcus aureus, and acetylacetone has environmental friendliness and is easy to apply and popularize.

The invention discloses Sansevieria trifasciata polysaccharides as well as a preparation method and application of the Sansevieria trifasciata polysaccharides. The Sansevieria trifasciata polysaccharides are prepared by the steps of: drying Sansevieria trifasciata leaf, crushing, screening, adding a certain volume of petroleum ether, refluxing with ethanol to remove impurities, carrying out suction filtering on the extract to obtain filter residue, and airing the filter residue for standby; extracting polysaccharides of Sansevieria trifasciata by a hot water leaching method, deproteinizing crude polysaccharides by combining an enzyme method with a Sevag method, and separating and purifying the deproteinized Sansevieria trifasciata polysaccharides TPS is by DEAE-52 column chromatography and SephdexG-100 column chromatography to respectively obtain four uniform components: TPS-A, TPS-B, TPS-C and TPS-H. TPS, TPS-H and TPS-A have obvious inhibitory action on the growth of human lung cancer cell A549, human nasopharyngeal carcinoma cell line CNE and human skin T cell lymphomata Hut102, and TPS-A has the best effect; and TPS, TPS-H and TPS-A have no inhibitory action on human colon cancer cell LoVo cell, and have no lethal effect on human intact liver cell LO2, thereby providing scientific reference for research and development of targeted antitumor medicaments.

The invention discloses application of an antigen containing 6-N-methyllysine residue in preparation of reagents or kits for auxiliary diagnosis of systemic lupus erythematosus. Experiments of the invention prove that human IgM can identify 6-N-methyllysine, and can be combined with arbitrary peptide or protein containing 6-N-methyllysine residue, 6-N-methyllysine has an inhibitory effect on IgM identifying 6-N-methyllysine, but non-methylation modified lysine has no inhibitory effect, most healthy people have a high level of the IgM antibody, and the level of the IgM antibody is significantly reduced in patients with systemic lupus erythematosus. The antigen containing 6-N-methyllysine residue can be used for preparation of reagents or kits for auxiliary diagnosis or screening of systemic lupus erythematosus.