Composite lysozyme oral spray and preparation method thereof

An oral spray, lysozyme technology, applied in the direction of topical antibacterial agents, drug combinations, pharmaceutical formulations, etc., can solve the problem of unusable prevention of oral diseases or daily cleaning of the mouth, fresh breath, inconvenience of driving for patients with oral diseases, and bacterial drug resistance. Gastrointestinal and other problems, to achieve the effect of difficult drug resistance, unique sterilization mechanism, and inhibition of oral Streptococcus mutans

Active Publication Date: 2014-04-09
JIANGSU XUE BAO DAILY CHEM CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditionally, antibiotics and antibacterial agents are used to kill oral pathogenic bacteria. For the convenience of use and quick effect, sprays are usually used for drug administration of oral diseases, but most of the sprays contain alcohol, which brings harm to patients with oral diseases such as driving. inconvenient
At the same time, antibiotics and bacteriostatic agents are likely to cause bacteria to develop drug resistance or side effects such as gastrointestinal discomfort, especially when oral diseases recur, the bactericidal effect of antibiotics and bacteriostatic agents will gradually decrease, affecting the therapeutic effect
Similarly, sprays containing antibiotics and antibacterial agents should not be used for a long time, and should not be used for daily health care to prevent oral diseases or for daily cleaning of the mouth and fresh breath

Method used

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  • Composite lysozyme oral spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take the preparation of 100 grams of compound lysozyme oral spray as an example:

[0034] 1. Weigh 3 grams of lysostaphin and 20 grams of lysozyme and dissolve in 30 grams of distilled water;

[0035] 2. Weigh 1 gram of sorbitol and 0.01 gram of xanthan gum and dissolve in 30 grams of distilled water;

[0036] 3. Mix and stir the solutions obtained in steps 1 and 2 to obtain Liquid A;

[0037] 4. Weigh 1 g of vitamin C and 0.02 g of tea polyphenols and dissolve in 12.47 g of distilled water;

[0038] 5. Weigh 1 gram of lecithin and add it to 1.5 grams of olive oil, stir in a constant temperature water bath to dissolve;

[0039] 6. Mix and stir the solutions obtained in steps 4 and 5 to obtain liquid B;

[0040] 7. Mix liquids A and B, and use a high-pressure homogenizer with a high pressure of 25MP to homogenize 3 times, and the product is the product;

[0041] 8. Filling at a temperature higher than 80 degrees Celsius.

Embodiment 2

[0043] Take the preparation of 200 grams of compound lysozyme oral spray as an example:

[0044] 1. Weigh 7 grams of lysostaphin and 45 grams of lysozyme and dissolve in 50 grams of distilled water;

[0045] 2. Weigh 6 grams of sorbitol and 0.1 grams of xanthan gum and dissolve them in 50 grams of distilled water;

[0046] 3. Mix and stir the solutions obtained in steps 1 and 2 to obtain Liquid A;

[0047] 4. Weigh 3 grams of vitamin C and 0.5 grams of tea polyphenols and dissolve them in 38.4 grams of distilled water;

[0048] 5. Weigh 3 grams of lecithin and add it to 5 grams of olive oil, stir in a constant temperature water bath to dissolve;

[0049] 6. Mix and stir the solutions obtained in steps 4 and 5 to obtain liquid B;

[0050] 7. Mix liquids A and B, and use a high-pressure homogenizer with a high pressure of 25MP to homogenize 3 times, and the product is the product;

[0051] 8. Filling at a temperature higher than 80 degrees Celsius.

[0052]

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Abstract

The invention relates to a composite lysozyme oral spray. The oral spray is characterized by comprising the following components in percentage by weight: 3-7 percent of lysostaphin, 20-25 percent of lysozyme, 0.02-0.4 percent of tea polyphenol, 1.5-5 percent of olive oil, 1-10 percent of vitamin C, 1-3 percent of sorbitol, 0.8-2 percent of lecithin, 0.01-0.07 percent of xanthan gum, and the balance of purified water. The oral spray is remarkable in effects and convenient to use, and does not contain alcohol; all components are extracted from natural products, and enable fresh breath and no toxic or side effect in the action of compatibility of composite lysozyme, tea polyphenol and vitamin C. The composite lysozyme oral spray has good preventing and treating effects on dental ulcer, decayed teeth, aphtha, halitosis, glossitis, sphagitis and other oral diseases; the preparation method is concise and effective and low in cost, and the prepared composite lysozyme oral spray is good in stability.

Description

technical field [0001] The invention relates to an oral spray biological preparation for killing oral pathogenic bacteria, in particular to a compound lysozyme oral spray and a preparation method thereof. Background technique [0002] The oral cavity is an important part of the digestive and respiratory systems of the human body. With the aggravation of air pollution and environmental deterioration, oral diseases are on the rise. [0003] Oral diseases are mostly caused by oral bacteria, such as oral ulcers, periodontal disease, tongue disease, dental caries, bad breath, pharyngitis, etc. Modern medicine believes that oral diseases can cause sepsis, diabetes, heart disease, etc. Therefore, killing oral pathogenic bacteria is the key to treating and preventing oral diseases. [0004] Traditionally, antibiotics and antibacterial agents are used to kill oral pathogenic bacteria. For the convenience of use and quick effect, sprays are usually used for drug administr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/47A61P1/02A61P11/04A61P31/02A61K36/82A61K31/375
Inventor 李秋雁陈新宇徐志良
Owner JIANGSU XUE BAO DAILY CHEM CO
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