An acoustic driver assembly for use with a spherical cavitation chamber is provided. The acoustic driver assembly includes at least one transducer, a head mass and a tail mass, coupled together with a centrally located threaded means (e.g., all thread, bolt, etc.). The driver assembly is permanently attached to the exterior surface of the spherical cavitation chamber via brazing or diffusion bonding. In at least one embodiment, the transducer is comprised of a pair of piezo-electric transducers, preferably with the adjacent surfaces of the piezo-electric transducers having the same polarity. The surface of the head mass that is adjacent to the external surface of the chamber has a spherical curvature equivalent to the spherical curvature of the external surface of the chamber, thus providing maximum coupling efficiency between the acoustic driver and the cavitation chamber. In at least one embodiment a void filling material is interposed between one or more pairs of adjacent surfaces of the driver assembly.