The invention provides a nourishing health wine. The nourishing health wine is prepared from the following raw materials: Baijiu of 48-55 degrees, sandalwood, aplotaxis auriculata, rhizoma kaempferiae, chrysanthemum morifolium, Chinese angelica, clove bud, dried orange peel, fructus amomi, fructus viticis, cassia twig, bamboo leaves, anise and rock candy. The preparation method of the nourishing health wine comprises the following steps: weighing such materials as sandalwood, aplotaxis auriculata, rhizoma kaempferiae, chrysanthemum morifolium, Chinese angelica, clove bud, dried orange peel, fructus amomi, fructus viticis, cassia twig, bamboo leaves, anise and rock candy for soaking into the Baijiu, after soaking for 30-40 days, extracting the medicine liquor by use of a cold-maceration method, and filtering the medicine liquor by use of a filter screen, thereby obtaining the nourishing health wine. According to the nourishing health wine and the preparation method thereof, the nourishing health wine is capable of overcoming the defects of the existing health wines, has the effects of improving the functions of intestines and stomach, regulating qi to alleviate pain, invigorating spleen to promote digestion, reinforcing kidney to strengthen yang, enduring fatigue, improving sleep, resisting oxidization and regulating blood fat, and is suitable for patients who suffer from hypertension, apoplexia, liver and kidney system diseases, diabetes and the like and cannot drink wines to drink daily.