The invention discloses all-solid-state folding intra-cavity sum frequency yellow orange laser vascular disease therapeutic apparatus. The therapeutic apparatus comprises a first pump light source and a second pump light source, wherein the first pump light source is connected with a first transmission optical fiber, the first transmission optical fiber is connected with a first optical coupling unit, a first input endoscope, a first laser gain medium and a first bi-color mirror lens are arranged beside the first optical coupling unit in sequence, one end of the first bi-color mirror lens is a sum frequency crystal, the other end of the first bi-color mirror lens is a second bi-color mirror lens, and a total-reflection endoscope is arranged beside the sum frequency crystal; the second pump light source is connected with a second transmission optical fiber, and a second optical coupling unit, a second input endoscope and a second laser gain medium are arranged between the second transmission optical fiber and the second bi-color mirror lens in sequence. The all-solid-state folding intra-cavity sum frequency yellow orange laser vascular disease therapeutic apparatus has the advantages of being small in size, low in weight, compact in structure, available in all-solid-state air cooling, low in electricity consumption, convenient to carry, and capable of improving pumping power and reducing side effects.