The invention discloses an abrasion and pierce proof low-resistance tire rubber compound and a preparation method thereof. The abrasion and pierce proof low-resistance tire rubber compound comprises, by weight, 40-70 parts of natural rubber SIR20, 10-15 parts of cis-polybutadiene rubber, 3-5 parts of styrene butadiene rubber SBR1500, 5-6 parts of N234 high-structure medium super abrasion furnace black, 5-6 parts of white carbon black, 1-1.5 parts of a silane coupling agent Si-69, 1-1.5 parts of polyethylene glycol, 0.5-1.0 part of toluene diisocyanate, 0.5-1.0 part of stannous chloride, 0.5-1.0 part of hydroxy-terminated polybutadiene, 1-1.5 parts of softening plasticizer aromatic oil, 1-2 parts of stearic acid, 2-3 parts of an antioxidant, 1-1.5 parts of tackifier 204 resin, 1-1.5 parts of a homogenizing agent UB4000, 0.5-1.0 part of zinc oxide, 1-1.5 parts of sulfur, 0.5-1.0 part of an XY900 anti-reversion agent, 1-1.5 parts of a promoter TBBS and 0.5-1.0 part of an anti-fatigue agent G-108. The tire rubber compound obtained in the invention has the advantages of good compatibility, abrasion proofing, pierce proofing, low resistance, fatigue proofing, ageing proofing, deformation proofing and wide application prospect.