The invention discloses a manufacturing method of a non-uniform crankle box girder rotary ladder. According to the construction scheme, the manufacturing method includes the steps that 1, flange plates and webs are lofted through a computer and then subjected to numerical control programming, and the flange plates and the webs are cut with plasma and discharged according to programming; 2, the flange plates and the webs are curled on a roller bed; 3, the projection contour of the rotary ladder is drawn on a bed mould, and the projection contour is divided into N equal parts corresponding to all levels of stairs; 4, the altitude differences of bisectrices relative to the stepping initial side are calculated, and a bed jig is welded to each bisectrix through profile steel according to the altitude differences; 5, bottom plates are spot-welded and assembled on the bed jigs; 6, the webs and the flange plates are spot-welded and assembled on the bottom plates; 7, top plates are spot-weldedand assembled on the flange plates and the webs, and step scribing of the levels of stairs is carried out; 8, the levels of stairs are spot-welded and assembled after discharging is completed throughnumerical control programming according to an expanded view of steps of the levels of stairs; 9, omni-bearing welding is carried out; and 10, inspection and coating are carried out. Assembly is carried out by simulating the actual mounting space structure size of the rotary profile steel ladder, the manufacturing precision is greatly improved, and the forming effect is good.