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110results about How to "Antifungal" patented technology

Penicillium chrysogenum antifungal protein Pc-Arctin and preparation method thereof

The invention discloses Penicillium chrysogenum antifungal protein Pc-Arctin and a preparation method thereof, and relates to microbial protein. The preparation method comprises the following steps of: picking Penicillium chrysogenum A096 from a flat, inoculating into an SGY liquid medium for culture, taking supernate, adding saturated ammonium sulfate to obtain a mixed solution, centrifuging, re-dissolving a precipitate in water to obtain a crude protein solution, dialyzing and centrifuging; separating and purifying the obtained crude protein solution on a diethyl amino ethyl anion exchange chromatographic column, collecting various eluted ingredients, performing centrifugal ultrafiltration and condensation, and tracking active ingredients; continuously separating and purifying concentrated active non-adsorption ingredients on a carboxymethyl anion exchange chromatographic column, collecting various eluted ingredients, performing centrifugal ultrafiltration and condensation on the various ingredients until a required volume is reached, tracking antifungal active ingredients by using Paecilomyces varioti as sensitive testee indicator bacteria, and judging the purity of the proteinfor the determined active ingredients; and cutting a single band from a sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) map and performing matrix-assisted laser desorption ionization-time of flight-time of flight (MALDI-TOF-TOF) identification.
Owner:THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION

Antifungal agent 2-[(2,3-dihydro-4H-benzo-[b]thiapyran-4-ylidene) hydrazono]-4-oxotetrahydro thiazole (oxazole)-5-acetic acid derivative

The invention relates to the technical field of medicines, in particular relates to a 2-[(2,3-dihydro-4H-benzo-[b]thiapyran-4-ylidene) hydrazono]-4-oxotetrahydro thiazole (oxazole)-5-acetic acid derivative or a salt thereof and a preparation method thereof, and also relates to a medicine taking the derivative or salt thereof as an active ingredient. Results of a test used for testing in vitro anti-fungal activity of the compound provided by the invention by adopting a two-fold concentration dilution method show that the compound has strong killing effect on clinically common pathogenic fungi and can overcome the defects that azoles antifungal drugs which are widely used clinically at present have high toxic and side effects, easily generate drug resistance and the like.
Owner:SHENYANG PHARMA UNIVERSITY +1

Drop for treating otitis externa mycotica and preparation method thereof

The invention relates to a compound ear drop for treating otitis externa mycotica, in particular to an ear drop for treating otitis externa mycotica. The drop is prepared by the the following ingredients: 3-30g of fluconazol, 5-50g of tinidazole, 3-30g of menthol, 100-800g of glycerine, 30-200ml of alcohol, 5-100ml of 1mol / L sodium hydroxide solution, and 1000ml of distilled water. The drop contains both antifungal drug and antianaerobic drug which enable the ear drop to have both antifungal activity and antianaerobic activity. In the process of preparation allocation, the tinidazole being slightly soluble into water need be heated by aqueous bath to be dissolved, the fluconazol and the menthol are easily dissolved into the alcohol. The alcohol is used for not only dissovling both the fluconazol and the menthol, but also being taken a transdermal accelerant of the ear drop, as well as drying the external acoustic meatus. The menthol can dispel wind to make the skin and the membrana mucosa cool and relieve the complaint and pain. A fixed amount of glycerine can protect the ear mucosa and keep the preparation tensile and adhesive.
Owner:周宣岩 +2

Condensation derivative of chitosan and substituted phenylthiosemicarbazide and preparation method thereof

The invention belongs to a marine chemical industry engineering technologies, and in particular relates to a novel condensation derivative of chitosan and substituted phenylthiosemicarbazide and a preparation method thereof. The invention provides a condensation derivative of chitosan and substituted phenylthiosemicarbazide, which has high water solubility, a novel structure and high bacteriostatic activity, and a preparation method thereof. The general formula of the novel condensation derivative of chitosan and substituted phenylthiosemicarbazide is shown as a formula I in the specification, wherein R1 is alkyl, halogen, trifluoromethyl or -NO2; R2 is -CH3, -CH2Cl or -Ar; and n=4-4000.
Owner:海臻(上海)生物科技有限公司

Chinese herbal medicine feed additive for preventing ichthyophthiriasis of dragonfish and preparation method of Chinese herbal medicine feed additive

The invention relates to a Chinese herbal medicine feed additive for preventing ichthyophthiriasis of dragonfish and further relates to a preparation method of the Chinese herbal medicine feed additive for preventing ichthyophthiriasis of dragonfish. The Chinese herbal medicine feed additive for preventing ichthyophthiriasis of dragonfish is prepared from, by mass, 15-22 parts of Chinese honeylocust fruit juice, 15-22 parts of calamendiol, 15-22 parts of folium artemisiae argyi, 10-18 parts of torilis japonica, 7-12 parts of pu-erh ripe tea, 10-16 parts of morning glory, 10-16 parts of herba houttuyniae, 8-18 parts of folium isatidis, 12-16 parts of gallnut, 12-18 parts of Chinese thorowax roots, 13-16 parts of garlic, 11-16 parts of coptis chinensis, 7-15 parts of milk vetch, 7-15 parts of fresh ginger, 8-13 parts of cortex phellodendri, 8-13 parts of moutan bark, 9-14 parts of resurrection lily rhizome, 6-13 parts of fructus cnidii and the like. The Chinese herbal medicine feed additive can decrease the morbidity of ichthyophthiriasis of dragonfish.
Owner:QINGDAO HAIZHIYUAN INTELLIGENT TECH

Preparation for preventing lateolabrax japonicus enteritis and preparation method thereof

The invention relates to a preparation for preventing lateolabrax japonicus enteritis and also relates to a preparation method of the preparation for preventing the lateolabrax japonicus enteritis. The preparation for preventing the lateolabrax japonicus enteritis is prepared from the following components in parts by mass: 27 to 35 parts of pomegranate barks, 22 to 26 parts of fresh hydrocotyle sibthorpioides juice, 21 to 26 parts of hibiscus barks, 21 to 25 parts of Rodgersia pinnata Franch., 20 to 25 parts of creeping oxalis, 19 to 23 parts of dandelions, 18 to 24 parts of aconitum gymnandrum maxim, 17 to 23 parts of houttuynia cordata, 17 to 22 parts of cocklebur fruits, 15 to 23 parts of hawthorn fruits, 14 to 20 parts of peruvian groundcherry herb, 14 to 20 parts of common cnidium fruits, 14 to 20 parts of lotus seeds, 13 to 19 parts of roots of Szechwan raspberry, 12 to 18 parts of Myositis sylvatica, 12 to 18 parts of Chinese galls, 10 to 18 parts of lophatherum gracile, 11 to 17 parts of resurrection lily rhizomes, 10 to 16 parts of blackberry lily and the like. The preparation for preventing the lateolabrax japonicus enteritis, provided by the invention, has a good treatment effect on the lateolabrax japonicus enteritis.
Owner:QINGDAO HAIZHIYUAN INTELLIGENT TECH

Acetophenone oxime ester imidazole derivative as well as preparation method and application thereof

The invention relates to the technical field of acetophenone oxime ester imidazole derivatives, in particular to acetophenone oxime ester imidazole derivatives as well as a preparation method and application thereof. According to the invention, a series of novel (E)-1-(2, 2-dimethylbenzo[d][1,3]dioxol-5-yl)-2-(1H-imidazole-1-yl)-1-ethanone oxime ester imidazole derivatives are designed and synthesized. The invention further explores the inhibitory activity of the derivative on LPS-induced neuroinflammation, and discusses the interrelation between the molecular structure of the compound and the inhibitory activity in combination with the influence of different substituents on the inhibitory activity, thereby further widening the deep study of the imidazole derivative on the aspect of neuritis resistance, and providing the experimental and theoretical bases for developing a novel medicine for treating the Alzheimer's disease.
Owner:NORTHWEST A & F UNIV
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