110results about How to "Antifungal" patented technology

The invention discloses Penicillium chrysogenum antifungal protein Pc-Arctin and a preparation method thereof, and relates to microbial protein. The preparation method comprises the following steps of: picking Penicillium chrysogenum A096 from a flat, inoculating into an SGY liquid medium for culture, taking supernate, adding saturated ammonium sulfate to obtain a mixed solution, centrifuging, re-dissolving a precipitate in water to obtain a crude protein solution, dialyzing and centrifuging; separating and purifying the obtained crude protein solution on a diethyl amino ethyl anion exchange chromatographic column, collecting various eluted ingredients, performing centrifugal ultrafiltration and condensation, and tracking active ingredients; continuously separating and purifying concentrated active non-adsorption ingredients on a carboxymethyl anion exchange chromatographic column, collecting various eluted ingredients, performing centrifugal ultrafiltration and condensation on the various ingredients until a required volume is reached, tracking antifungal active ingredients by using Paecilomyces varioti as sensitive testee indicator bacteria, and judging the purity of the proteinfor the determined active ingredients; and cutting a single band from a sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) map and performing matrix-assisted laser desorption ionization-time of flight-time of flight (MALDI-TOF-TOF) identification.

The invention discloses a shampoo salt emulsion and a preparation method thereof. The shampoo salt emulsion is characterized by comprising the following components in parts by weight: 10-30 parts of edible salt, 10-40 parts of surfactant, 0.1-5 parts of suspension stabilizer, 1-10 parts of emulsified silicone oil, 0.1-5 parts of thickening agent, 0.1-1.5 parts of anti-dandruff agent, 0.1-3 parts of essential oil extracted from spice, 0.1-4 parts of humectant, 0.1-3 parts of positive ion conditioner, 0-5 parts of nutritive additive and 30-70 parts of deionized water. The invention also relatesto a preparation method of the shampoo salt emulsion. Compared with the prior art, the shampoo salt emulsion has the advantages that the shampoo salt emulsion fully plays a synergistic effect of the edible salt and the anti-dandruff agent in the concentration range of 10-30 parts of salt containing amount and 0.1-1.5 parts of anti-dandruff agent; the respective beneficial effect of the edible salt and the anti-dandruff agent can be improved; and in addition, the natural salt can play functions of sterilization and corrosion resistance; and the product safety can be greatly improved.

The invention discloses a method for increasing the content of cucurbitadienol in momordica grosvenori. Jasmonic acid methyl ester is added in the tissue culture process and / or planting process of the momordica grosvenori. The method is capable of effectively increasing the yield of the cucurbitadienol in the momordica grosvenori, has the advantages of being rapid in effect taking, low in cost, simple to operate, convenient to implement, free of toxin or residue and the like, is capable of meeting large-scale production of the cucurbitadienol in the momordica grosvenori, and has relatively good practicability and high popularization values.

The utility model relates to marine chemical engineering technology, in particular to a novel chitosan thiosemicarbazone derivatives and preparation method. The derivatives are (1) compounds: the preparation method is that: Chitosan firstly reacts with aniline Thiourea of different substituting groups in HAc solvent; then reaction product is settled through organic solvent and then the sediment is filtered and cleaned by organic solvent. The sediment is dried and then is withdrawn through organic solvent. The extract becomes derivative after vacuum drying. The substitution rate of the derivatives prepared in the utility model is up to 18.2 percent to 35.6 percent and is of good water solubility. The thiosemicarbazone and the chitosan molecules are effectively combined to increase the effectiveness thorough cooperation. The utility model can significantly enhance the biological activities of the chitosan, such as the antibacterial property, anti-virus property and so on. The utility model is applicable to pharmaceuticals, cosmetics, agriculture, and other fields.

The invention pertains to the technical field of medicaments, more particularly relates to a (sulfur) urea derivative with substituted semicarbazone thiochromanones and provides a novel and efficient antifungal agent. The structural formula of the derivative is shown as the Formula I. The invention also relates to a chemically acceptable compound of the derivative and a medicament combination taking the compound as an active ingredient. As a novel antifungal agent, the compound has relatively strong effect of killing pathomycete commonly seen clinically and is expected to overcome the defects that azoles antifungal medicaments widely used in clinical treatment has serious toxic side effect and is easy to generate medicament resistance, and the like. The compound is prepared by the condensation of substitutable thiochromanones and substitutable semicarbazone (sulfur) in an organic solvent.

The present invention discloses one kind of essence containing natural vegetable oils for daily use to reach health functions. The essence is compounded with over 20 kinds of vegetable oils and other natural plant extracts, including arborvitae oil, celery seed oil, spikenard oil, borneol, thymol, etc in certain weight proportion. The essence of the present invention may be used in different daily use chemical products to regulate smell and increase health functions.

The antifungal medicine composition is medicine prepared with the materials including snake oil 50-100 weight portions, Miconazole nitrate 25-50 weight portions, flavescent sophora root 20-50 weight portions, pearl powder 1-10 weight portions, menthol 1-5 weight portions, and borneol 1-5 weight portions. The antifungal medicine composition as one compound Chinese and Western medicine preparation contains effective antifungal components, and components for clearing away heat and toxic material, eliminating swelling, relieving pain, astringing and promoting granulation. It is used in treating tinea corporis, tinea cruris, tinea manuum, tinea pedis, etc caused by mycotic infection, and has stable treating effect and little side effect.

The invention discloses a traditional Chinese medicine medicated bath prescription for treating tinea pedis. The traditional Chinese medicine medicated bath prescription is prepared from the following traditional Chinese medicinal materials in parts by weight: 20-30 g of licorice, 15-30 g of herba agastachis, 20-30 g of Chinese rhubarb, 1.5-3 g of alum, 10-30 g of belvedere fruit, 3-12 g of phellodendron bark, 30-40 g of ragwort, 20-40 g of dittany bark, 15-30 g of rhizoma atractylodis, 10-20 g of smilax glabra rhizome, and 3-9 g of radix arnebiae. The prescription is reasonable in matching, exerts the effects of clearing away heat and toxic material, eliminating inflammation, relieving pain, relieving itching, clearing away and inhibiting tinea, dehumidifying, removing slough, and aiding growth of new muscle by adopting a foot soaking method, has simple matching method and low medicine cost, does not need for oral medicaments, and has significant curative effect to tinea pedis.

The invention discloses a hand wash with sterilizing and skin-care effects and a preparation method thereof. The hand wash is prepared from the following components in parts by weight: 15 to 25 partsof lemongrass herb extract, 10 to 20 parts of honeysuckle flower extracting solution, 5 to 10 parts of soapberry seed extract, 0.1 to 0.5 part of hyaluronic acid, 25 to 35 parts of edible olive oil, 20 to 40 parts of edible coconut oil, 1 to 3 parts of sodium hydroxide, and 100 to 150 parts of pure water. The hand wash with sterilizing and skin-care effects has the advantages that the fragrant ispleasant and natural, and the stability is good; multiple effects of deeply cleaning skin, resisting bacteria and diminishing inflammation, moisturizing skin, whitening and resisting oxidizing, removing dampness and relieving itching and the like are realized; the growth of bacteria at the skin surface can be effectively inhibited; the safety is realized, the toxicity is avoided, the moderate andnon-irritation effects to skin are realized, and the hand wash is suitable for all users.

The invention discloses a spray for treating fungus infection on the body surface of a pet and a preparation method of the spray and aims to provide a spray which is used for treating fungus infection on the body surface of the pet and is simple in preparation method, convenient to use, good in curative effect and high in safety. The technical key points are as follows: on one hand, the invention provides the spray for treating fungus infection on the body surface of the pet, and the spray is composed of the following components in parts by weight: 65-95 parts of alcohol, 0.1-5 parts of terbinafine hydrochloride, 0.1-5 parts of azone, 5-20 parts of extracts of a traditional Chinese medicine composition and 0.1-5 parts of eugenol, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-20 parts of fructus cnidii, 3-10 parts of rhubarb, 2-8 parts of litsea cubeba, 2-5 parts of cortex dictamni and 3-7 parts of fructus kochiae; and on the other hand, the invention provides a preparation method of the spray. The spray and the preparation method thereof belong to the technical field of medicines for animals.

The invention relates to a tanshinone IIA derivate comprising a polyethylene glycol group and preparation and application of the tanshinone IIA derivate. The tanshinone IIA derivate comprising the polyethylene glycol group and the preparation and application of the tanshinone IIA derivate have the benefits as follows: the provided novel tanshinone IIA derivate can be used for treatment of cardiovascular and cerebrovascular diseases; the tanshinone IIA derivate comprising the polyethylene glycol group has better water solubility and can enter the blood-brain barrier, therefore the curative effect is improved, and the bioavailability of the tanshinone IIA derivate is greatly improved.

The invention relates to a traditional Chinese medicine spicy hot hot-pot condiment. The traditional Chinese medicine spicy hot hot-pot condiment is prepared from the following raw materials in parts by weight: 0.01 to 0.03 part of Chinese angelica, 0.01 to 0.03 part of liquorice root, 0.01 to 0.03 part of radix codonopsis, 0.005 to 0.015 part of Radix Astragali seu Hedysari, 0.01 to 0.03 part of radix Adenophorae, 200 to 300 parts of mixed plant oil, 350 to 450 parts of chili, 8 to 12 parts of bean paste, 8 to 12 parts of fermented soya beans, 18 to 22 parts of edible salt, 3 to 5 parts of monosidum glutamate, 4 to 6 parts of pepper, 0.8 to 1.2 parts of anise, 0.8 to 1.2 parts of fennel, 0.1 to 0.3 part of Amomum villosum Lour, 0.08 to 0.12 part of Flos Caryophylli and 0.1 to 0.3 part of cassia bark. The invention further provides a preparation method of the traditional Chinese medicine spicy hot hot-pot condiment. The traditional Chinese medicine spicy hot hot-pot condiment has spicy and delicious tastes and not easy to get inflamed. According to the preparation method disclosed by the invention, the fragrance and nutritional ingredients of chili are developed well, such that not only the taste is greatly promoted, and the nutrition is also greatly promoted.

The invention discloses a resin synthetic board and a manufacturing method thereof, and belongs to the field of synthetic boards. The resin synthetic board is formed by laminating a resin synthetic board and a decorative film, wherein the decorative film is covered on the surface of the resin synthetic board; the resin synthetic board is prepared from the following components in percentage by mass: 10 to 15% of pine wood powder, 10 to 15% of fir wood powder, 40 to 69% of poplar wood powder, 0.01 to 0.08% of zinc stearate, 0.01 to 0.2% of titanium dioxide, and 10 to 40% of melamine formaldehyde resin; the decorative film is made of solid paper immersed by the melamine formaldehyde resin. The resin synthetic board has the advantages that the pine wood powder, the fir wood powder and the poplar wood powder are laminated into the high-density resin synthetic board, so that the high-density resin synthetic board has stronger anti-corrosive property, the easiness in aging is avoided, and the compressive strength is higher; the easiness in delaminating and falling of the decorative film is avoided, and the surface of the decorative film is smoother; after the decorative film is immersed by the melamine formaldehyde resin, the better abrasion-resistant property is realized.

The invention relates to the technical field of medicines, in particular relates to a 2-[(2,3-dihydro-4H-benzo-[b]thiapyran-4-ylidene) hydrazono]-4-oxotetrahydro thiazole (oxazole)-5-acetic acid derivative or a salt thereof and a preparation method thereof, and also relates to a medicine taking the derivative or salt thereof as an active ingredient. Results of a test used for testing in vitro anti-fungal activity of the compound provided by the invention by adopting a two-fold concentration dilution method show that the compound has strong killing effect on clinically common pathogenic fungi and can overcome the defects that azoles antifungal drugs which are widely used clinically at present have high toxic and side effects, easily generate drug resistance and the like.

The invention relates to a Chinese herbal medicine preparation for treating a white head-mouth disease of xiphophorus helleri. The invention further relates to a preparation method of the Chinese herbal medicine preparation for treating the white head-mouth disease of the xiphophorus helleri. The Chinese herbal medicine preparation for treating the white head-mouth disease of the xiphophorus helleri is prepared from, by mass, 25-33 parts of aqueous extract of garden burnet roots, 22-28 parts of common cephalanoplos herb juice, 7-14 parts of pu-erh ripe tea, 20-26 parts of bitter herbs, 19-26 parts of cluster mallow, 15-23 parts of morning glories, 19-25 parts of spica prunellae, 21-28 parts of Chinese honeylocust fruit, 17-25 parts of rhizoma atractylodis, 17-23 parts of Chinese milk vetch, 13-22 parts of heartleaf houttuynia herbs, 16-24 parts of honeysuckle flowers, 16-24 parts of common cnidium fruit, 14-22 parts of Chinese gall, 15-24 parts of pagoda tree fruit and the like. The Chinese herbal medicine preparation for treating the white head-mouth disease of the xiphophorus helleri can effectively treat the white head-mouth disease of the xiphophorus helleri.

The invention relates to a compound ear drop for treating otitis externa mycotica, in particular to an ear drop for treating otitis externa mycotica. The drop is prepared by the the following ingredients: 3-30g of fluconazol, 5-50g of tinidazole, 3-30g of menthol, 100-800g of glycerine, 30-200ml of alcohol, 5-100ml of 1mol / L sodium hydroxide solution, and 1000ml of distilled water. The drop contains both antifungal drug and antianaerobic drug which enable the ear drop to have both antifungal activity and antianaerobic activity. In the process of preparation allocation, the tinidazole being slightly soluble into water need be heated by aqueous bath to be dissolved, the fluconazol and the menthol are easily dissolved into the alcohol. The alcohol is used for not only dissovling both the fluconazol and the menthol, but also being taken a transdermal accelerant of the ear drop, as well as drying the external acoustic meatus. The menthol can dispel wind to make the skin and the membrana mucosa cool and relieve the complaint and pain. A fixed amount of glycerine can protect the ear mucosa and keep the preparation tensile and adhesive.

The invention belongs to a marine chemical industry engineering technologies, and in particular relates to a novel condensation derivative of chitosan and substituted phenylthiosemicarbazide and a preparation method thereof. The invention provides a condensation derivative of chitosan and substituted phenylthiosemicarbazide, which has high water solubility, a novel structure and high bacteriostatic activity, and a preparation method thereof. The general formula of the novel condensation derivative of chitosan and substituted phenylthiosemicarbazide is shown as a formula I in the specification, wherein R1 is alkyl, halogen, trifluoromethyl or -NO2; R2 is -CH3, -CH2Cl or -Ar; and n=4-4000.

The invention belongs to the field of organic synthesis, and provides a polysubstituted alpha-alkenyl lactone compound, and a preparation method and application thereof, the structure of the polysubstituted alpha-alkenyl lactone compound is as follows that: R1 is selected from aryl or heteroaryl, R2 and R3 are respectively and independently selected from C1-C6 alkyl, R4 and R5 are each independently selected from an aryl group, and an aromatic heterogroup or a C1-C6 alkyl group. The polysubstituted alpha alkenyl lactone compound is obtained by reacting acetylenic acid with allyl alcohol or allyl butanol for 1-24 hours from room temperature to reflux temperature under the action of a catalyst and a hydrogen source. According to the method, the target product can be prepared through one-stepreaction, and the method is simple in synthesis method, simple in process equipment, easy to operate, environmentally friendly, low in cost and good in yield.

A nonwoven material capable of realizing one time absorption of articles is coated with a lavender finishing agent, the lavender finishing agent is obtained by dissolving natural lavender essential oil in an alcoholic solvent, and the content of the natural lavender essential oil is 5-15wt%. The nonwoven material capable of realizing one time absorption of articles can be used to absorb the surface layer or liquid transmission layer of the articles, and has sterilizing, calming and sleep comforting efficacies.

The invention relates to a Chinese herbal medicine feed additive for preventing ichthyophthiriasis of dragonfish and further relates to a preparation method of the Chinese herbal medicine feed additive for preventing ichthyophthiriasis of dragonfish. The Chinese herbal medicine feed additive for preventing ichthyophthiriasis of dragonfish is prepared from, by mass, 15-22 parts of Chinese honeylocust fruit juice, 15-22 parts of calamendiol, 15-22 parts of folium artemisiae argyi, 10-18 parts of torilis japonica, 7-12 parts of pu-erh ripe tea, 10-16 parts of morning glory, 10-16 parts of herba houttuyniae, 8-18 parts of folium isatidis, 12-16 parts of gallnut, 12-18 parts of Chinese thorowax roots, 13-16 parts of garlic, 11-16 parts of coptis chinensis, 7-15 parts of milk vetch, 7-15 parts of fresh ginger, 8-13 parts of cortex phellodendri, 8-13 parts of moutan bark, 9-14 parts of resurrection lily rhizome, 6-13 parts of fructus cnidii and the like. The Chinese herbal medicine feed additive can decrease the morbidity of ichthyophthiriasis of dragonfish.

The invention discloses biological fermented meat duck feed. The biological fermented meat duck feed comprises, by weight, 20-30 parts of corn, 15-20 parts of black bean flour, 7-10 parts of corn stalk powder, 5-10 parts of soybean concentrated proteins, 10-15 parts of weed seeds, 6-9 parts of vegetable waste, 6-8 parts of palm kernel meal, 8-10 parts of ziziphus jujube leaves, 5-10 parts of conchmeal, 5-10 parts of bean pulp, 2-5 parts of orange peel, 3-7 parts of shrimp head meal, 1-2 parts of biological bacteria, 1-2 parts of complex enzyme preparations, 1-4 parts of salt, 0.8-2 parts of mushroom, 1-3 parts of bean worms, 1-3 parts of broken stone, 0.5-0.8 part of multi-vitamins, 0.1-0.4 part of lysine, 0.05-0.15 part of methionine and 1-3 parts of calcium hydrophosphate. The biological fermented meat duck feed has the advantages that the biological bacteria and the complex enzyme preparations are matched with one another, accordingly, the biological fermented meat duck feed can besynergistically fermented, and the average daily weight gain and the feed intake of meat ducks can be increased after non-fermented feed is replaced with the biological fermented meat duck feed.

The invention discloses a tetrahydrofuran compound and a preparation method and application thereof. The invention is characterized in that the structural formula of the tetrahydrofuran compound is as shown in the formula I. The preparation method comprises the following steps: acquiring a fermented substance containing a novel tetrahydrofuran compound by fermental cultivation of aspergillus versicolor with the preservation number of CCTCC No. M2014089; immersing the fermented substance with methanol and extracting with ethyl acetate so as to obtain a crude extract; and separating and purifying the crude extract by reduced pressure silica-gel column chromatography and semi-preparative reversed phase high-performance liquid chromatography. The tetrahydrofuran compound has an antifungal effect and can be used as a novel medicine component or lead compound with an antifungal effect.

The invention relates to a preparation for preventing lateolabrax japonicus enteritis and also relates to a preparation method of the preparation for preventing the lateolabrax japonicus enteritis. The preparation for preventing the lateolabrax japonicus enteritis is prepared from the following components in parts by mass: 27 to 35 parts of pomegranate barks, 22 to 26 parts of fresh hydrocotyle sibthorpioides juice, 21 to 26 parts of hibiscus barks, 21 to 25 parts of Rodgersia pinnata Franch., 20 to 25 parts of creeping oxalis, 19 to 23 parts of dandelions, 18 to 24 parts of aconitum gymnandrum maxim, 17 to 23 parts of houttuynia cordata, 17 to 22 parts of cocklebur fruits, 15 to 23 parts of hawthorn fruits, 14 to 20 parts of peruvian groundcherry herb, 14 to 20 parts of common cnidium fruits, 14 to 20 parts of lotus seeds, 13 to 19 parts of roots of Szechwan raspberry, 12 to 18 parts of Myositis sylvatica, 12 to 18 parts of Chinese galls, 10 to 18 parts of lophatherum gracile, 11 to 17 parts of resurrection lily rhizomes, 10 to 16 parts of blackberry lily and the like. The preparation for preventing the lateolabrax japonicus enteritis, provided by the invention, has a good treatment effect on the lateolabrax japonicus enteritis.

The invention discloses a washing machine tank cleaning agent and a preparation method thereof, and relates to the technical field of cleaning agents. The washing machine tank cleaning agent is prepared by mixing, by weight, 20-25 parts of folium artemisiae argyi, 10-15 parts of Chinese soapberry fruits, 6-8 parts of raw salt and 1-3 parts of essential oil. Chinese soapberry fruits adopted in the cleaning agent are from deciduous trees, peel contains soapnut saponin and other triterpenoid saponin, and the natural and pollution-free cleaning agent can be prepared, and is used for daily washing, tableware cleaning, face beautifying, hair washing, skin healthcare and the like. Folium artemisiae argyi is dried leaves of feverfew Chinese mugwort, and has faint scent, bitter tastes and an antimycotic function. Raw salt has the functions of sterilization and disinfection. Essential oil can remove the stale odor of a washing machine tank. Compared with the prior art, pure natural plants are adopted as raw materials, safety and environment friendliness are achieved, preparation is easy, the sterilizing and washing effect is good, and the cleaning agent is harmless to the skin.

The present invention belongs to the field of gene engineering technology, and especially a kind of active promoter segment F1 of Bacillus pumilus, its fusion gene constructing body and new recombinant expression vector carrying the constructing body. The present invention also relates to the said random alveolus mutation, antifungal protein acquisition, expression vector transformed Bacillus pumilus cell and transformed cell generated antifungal function. The said promoter activity improvement can resist chloromycetin as high as 900 mcg / ml, and the obtained antifungal protein secretion obtained under the directing of the promoter has certain antifungal characteristic.

The oral cavity cleaning essence contains lemon oil and mint oil as well as proper amount of eucalyptus leaf oil, clove seed oil, myrrh oil, rosemary oil and tea seed oil. It has the effect of freshening oral smell and ability of inhibiting bacteria growth, killing bacteria and fungi in oral cavity, resisting oral cavity inflammation and eliminate oral cavity breeding. It is suitable for use inpreparing chewing gum for cleaning oral cavity and various oral cavity health articles, such as toothpaste, oral cavity spray, etc.

The present invention belongs to the field of gene engineering technology, and especially a kind of active promoter segment F1 of Bacillus pumilus, its fusion gene constructing body and new recombinant expression vector carrying the constructing body. The present invention also relates to the said random alveolus mutation, antifungal protein acquisition, expression vector transformed Bacillus pumilus cell and transformed cell generated antifungal function. The said promoter activity improvement can resist chloromycetin as high as 900 mcg / ml, and the obtained antifungal protein secretion obtained under the directing of the promoter has certain antifungal characteristic.

The invention relates to a feed additive for preventing haemorrhagic septicaemia of ictalurus punctatus and further relates to a preparation method of the feed additive for preventing haemorrhagic septicaemia of ictalurus punctatus. The feed additive for preventing haemorrhagic septicaemia of ictalurus punctatus is composed of the following ingredients in parts by mass: 30-36 parts of couch grass root, 23-29 parts of folium artemisiae argyi, 23-29 parts of garlic juice, 21-29 parts of white gourd seeds, 21-29 parts of lophatherum gracile, 20-27 parts of fructus cnidii, 20-27 parts of divaricate saposhnikovia root, 19-27 parts of sanguisorba officinalis, 19-25 parts of lawn pennywort herb juice, 18-26 parts of rodgersia pinnata, 18-26 parts of Japanese pearlwort herb, 17-27 parts of common cephalanoplos herb, 16-25 parts of heartleaf houttuymia herb and the like. The feed additive for preventing haemorrhagic septicaemia of ictalurus punctatus can effectively avoid haemorrhagic septicaemia.

The invention provides a traditional Chinese medicine composition for treating osteoarthropathy and a preparation thereof. The traditional Chinese medicine composition comprises the following components: coptis chinensis, scutellaria baicalensis, golden cypress, golden cypress and golden cypress. The traditional Chinese medicine composition and preparation thereof have good actions of promoting blood circulation to remove blood stasis, restoring menstrual flow, promoting qi circulation and removing obstruction in the collaterals, removing stasis and enriching blood, relieving pain and dispelling melancholy and have a remarkable curative effect on clinical patients with osteoarthropathy from clinical symptoms, sign improvement and relapse control.

The invention relates to the technical field of acetophenone oxime ester imidazole derivatives, in particular to acetophenone oxime ester imidazole derivatives as well as a preparation method and application thereof. According to the invention, a series of novel (E)-1-(2, 2-dimethylbenzo[d][1,3]dioxol-5-yl)-2-(1H-imidazole-1-yl)-1-ethanone oxime ester imidazole derivatives are designed and synthesized. The invention further explores the inhibitory activity of the derivative on LPS-induced neuroinflammation, and discusses the interrelation between the molecular structure of the compound and the inhibitory activity in combination with the influence of different substituents on the inhibitory activity, thereby further widening the deep study of the imidazole derivative on the aspect of neuritis resistance, and providing the experimental and theoretical bases for developing a novel medicine for treating the Alzheimer's disease.