170 results about "Thiocarbamide derivatives" patented technology

The present invention relates to biscarbodiimides, thiourea derivatives, urea derivatives, and cross-linked hyaluronan derivatives having at least one intramolecular disulfide bond, and methods of preparation thereof. The invention also includes thiolated hyaluronan derivatives and salts thereof having at least one pendant thiol group or a modified pendant thiol group, and methods of preparation thereof. An example of a modified pendant thiol group is a sulfhydryl group linked to a small molecule such as a bioactive agent, for example a drug or pharmaceutically active moiety. A hyaluronan derivative having a sulfhydryl group linked to a pharmaceutically active moiety is useful as a sustained or controlled release drug delivery vehicle. Compositions containing the hyaluronan derivatives of the invention can reversibly viscosify in vivo or in vitro, in response to mild changes in condition, and are thus useful in ophthalmic surgery and in tissue engineering.

Methods and compositions for the treatment of pain using thiourea derivatives. Particularly disclosed are new compositions for the treatment of chronic pain, and methods for their use.

A two-part self-curing endodontic sealing system comprises a thiourea derivative, such as acetyl thiourea, and a hydroperoxide, such as cumene hydroperoxide. The thiourea derivative is used as a reducing agent and the hydroperoxide is used as an oxidizing agent.

A two-component initiator system having accelerators for curing polymerizable materials comprising the following components: (a) a hydroperoxide compound containing one or more hydroperoxide groups that are bound to a tertiary carbon; (b) a thiourea derivative; and (c) as accelerator, a copper compound which is soluble in the preparation is preferably free of amine and is particularly suited for polymerizable dental compositions.

Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and / or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I) to (VIII), or a pharmaceutically acceptable salt thereof.

The present invention relates to the use of S-alkylisothiouronium derivatives, including S-ethylisothiouronium diethylphosphate, for stabilizing blood pressure in hemodialysis patients. The compositions of the invention are effective in preventing hypotension in hemodialysis patients.

Disclosed are electrolyte compositions for depositing a tin alloy on a substrate. The electrolyte compositions include tin ions, ions of one or more alloying metals, an acid, a thiourea derivative, and an additive selected from alkanol amines, polyethylene imines, alkoxylated aromatic alcohols, and combinations thereof. Also disclosed are methods of depositing a tin alloy on a substrate and methods of forming an interconnect bump on a semiconductor device.

The invention relates to a corrosion inhibitor used in carbon steel corrosion in an ammonia-method desulphurization ammonium sulfate preparation system. The corrosion inhibitor is composed of, by weight, 20-80% of a thiourea derivative, 10-50% of organic amine, and 5-40% of imidazoline quaternary ammonium salt. The thiourea derivative is one selected from phenyl thiourea, diphenyl thiourea, thiosemicarbazide and propenyl thiourea. The organic amine is one selected from polyacrylamide, dodecylamine, hexadecylamine and octadecylamine. The chemical structural formula of the imidazoline quaternary ammonium salt is represented as the following, wherein R is phenyl, C2-C11 straight-chain alkyl, CH3(CH2)7CH=CH(CH2)7 or CH3(CH2)9CH=CH(CH2)7, and n is 2, 3, or 4. The corrosion inhibitor has good corrosion inhibiting performance. When the corrosion inhibitor is applied in inhibiting the corrosion in the ammonia-method desulphurization ammonium sulfate preparation system, the dose is low, and application is simple and convenient.

The invented corrosion inhibitor includes following percentages (weight) of constituent; rosin amine 10-40%, element acid 5-30%, thiourea and ramification of thiourea 5-30% and solvent 10-50%. According to molecular design method, the corrosion inhibitor is prepared by adopting macromolecular compounds, small molecule compounds and negative ions with specific adsorption. Thus, the inhibitor restrains the corrosion of pipeline made of carbon steels in wider temperature region and the environment containing CO2, no matter the surface of the pipeline is clean or covered by the film of corrosion product. The invention corrosion inhibitor provides the features of wide suitable area, small use level, high efficiency, easy to produce, avirulence and non-peculiar smell as well as complete water-solubility.

The present invention relates to biscarbodiimides, thiourea derivatives, urea derivatives, and cross-linked hyaluronan derivatives having at least one intramolecular disulfide bond, and methods of preparation thereof. The invention also includes thiolated hyaluronan derivatives and salts thereof having at least one pendant thiol group or a modified pendant thiol group, and methods of preparation thereof. An example of a modified pendant thiol group is a sulfhydryl group linked to a small molecule such as a bioactive agent, for example a drug or pharmaceutically active moiety. A hyaluronan derivative having a sulfhydryl group linked to a pharmaceutically active moiety is useful as a sustained or controlled release drug delivery vehicle. Compositions containing the hyaluronan derivatives of the invention can reversibly viscosify in vivo or in vitro, in response to mild changes in condition, and are thus useful in ophthalmic surgery and in tissue engineering.

The present application provides a stable topical composition comprising a compound of 1,2,4-thiadiazole derivatives and the related thiourea derivatives. The stable topical composition may be present in various forms, including aqueous gel, cream, and emulsion. The stable topical composition may be stored at refrigerated or ambient condition for a reasonable shelf-life. The present application also provides a method of treating dermatologic disorders mediated by a melanocortin receptor using the stable topical composition. The stable composition may be delivered using a single chamber or dual chamber device. A method of preparing and delivering the stable composition is also provided.

The invention provides a novel imidazoline compound corrosion inhibitor and belongs to the field of metal corrosion inhibition. The corrosion inhibitor aims at solving the problems that most oxidation film type corrosion inhibitors and precipitating film type corrosion inhibitors contain heavy metal or the phosphorus element, are large in toxicity and severely pollute the environment. The effective components of the corrosion inhibitor are formed by compounding, by mass, 10% to 30% of thiourea derivatives, 5% to 30% of alkali halide, 30% to 80% of imidazoline-ammonium-salt derivatives and 0 to 15% of urotropin. Raw materials or components of the novel imidazoline compound corrosion inhibitor prepared through the process are simple and easy to obtain and free of or low in toxicity, the characters of molecules of all the components are greatly different, the radii of the molecules of all the components are greatly different as well, and the complementary performance is high; all the components can be adsorbed to the metal surface after being compounded to form a dense monomolecular film; and the corrosion inhibitor has the beneficial effects of being good in universality, small in use amount, high in efficiency, low in toxicity, good in stability, simple in preparation process, low in cost and the like.

Novel compounds of formula (I) to (VI), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and / or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I)-(VI), or a pharmaceutically acceptable salt thereof.

Novel compounds of formula (I) to (VI), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and / or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I)-(VI), or a pharmaceutically acceptable salt thereof

The invention relates to a long-service-life high-speed acid environment protection bright chemical nickel plating additive and a use method thereof. A complexing agent in the additive is a mixture of three kinds or more than three kinds of materials in lactic acid, malic acid, citric acid, glycine, glycollic acid and salicylic acid through being mixed according to any proportion. A stabilizing agent is a composite stabilizing agent prepared from thiosemicarbazone derivatives and oxygenated chemicals according to a mass ratio of 1 / 10 to 30, and the oxygenated chemicals are iodate or molybdateor bromate, an accelerating agent is one kind of materials in glutaric acid or adipic acid. A buffering agent is prepared from either boric acid or sodium tetraborate and either acetic acid or sodiumacetate according to a mass ratio of 1 / 2 to 5. The chemical nickel plating additive of the invention can realize the mass production. When being used, the chemical nickel plating additive is directlyadded into water to be diluted according to the proportion for use, and the operation is simple. After the use for 8 to 10 periods, the plating layer performance and the speed are still stable, the stability of plating liquid is good, nickel is not separated out from the wall of a tank, the phosphorus content of the plating layer is stabilized ranged from 5 to 8 percent, and the plating layer is bright.

The invention discloses a fluorescent probe made of rhodamine B, diethylenetriamine and PITC (phenyl isothiocyanate) as well as a preparation method and an application thereof. Specifically, rhodamine B and diethylenetriamine react firstly to form a spiro amide structure with a stable property, a nitrogen bridging fragment is introduced, and the mixture then reacts with PITC so as to introduce a sulfur atom. By means of sulphophile affinity of mercury ions, each molecule of a novel rhodamine B-phenylthiourea derivative (namely, mercury ion fluorescent probe RDTU) obtained through the scheme can be combined with two mercury ions, so that the fluorescent probe has higher selectivity and detection sensitivity. The molecules of the fluorescent probe can perform detection in a neutral buffer solution especially in water phase. Additionally, the molecules of the fluorescent probe can detect the mercury ions from mercury chloride, and has better practicability.

The invention discloses an electrolyte composition for depositing tin alloy on a substrate. The electrolyte composition includes tin ions, one or more alloy metal ions, an acid, a thiourea derivative and an additive selected from the group consisting of alkanolamines, polyethyleneimines, alkoxylated Aromatic alcohols and mixtures thereof. Also disclosed are methods of depositing tin alloys on substrates, and methods of forming interconnect bumps on semiconductor devices.

It is an object of the invention to provide a two-layer flexible substrate that excels in folding endurance and free from occurrence of Kirkendall voids or the like even when lead portions of COF are plated with tin and heat treatment is performed. The present invention is directed to a two-layer flexible substrate in which a copper layer is provided on one or both faces of an insulating film by using a copper electrolytic solution, wherein an average size of copper crystal grains constituting the copper layer is equal to or greater than 1 μm and equal to or less than a thickness of the copper layer, and a ratio of peak intensity of (200) to a sum total of intensities of six principal peaks {[peak intensity of (200)] / [sum total of peak intensities of (111), (200), (220), (311), (400), (331)]} in the X-ray diffraction of the copper layer is equal to or greater than 0.4. The above copper electrolytic solution for forming the copper layer contains a chloride ion and one or more of thiourea, thiourea derivatives, and thiosulfuric acid as additives.

A two-part self-curing endodontic sealing system comprises a thiourea derivative, such as acetyl thiourea, and a hydroperoxide, such a cumene hydroperoxide. The thiourea derivative is used as a reducing agent and the hydroperoxide is used as an oxidizing agent.

Disclosed is a two-layered flexible substrate which has excellent bending endurance, and furthermore, wherein Kirkendall voids do not arise even if a chip-on-film lead section is tin plated and heat treatment is performed. The disclosed two-layered flexible substrate is provided with a copper layer using a copper electrolyte on one or both faces of an insulating film, and is characterized by the copper crystal grains forming the aforementioned copper layer having a grain size of at least 1 [mu]m and no more than the thickness of the copper layer, and by X-ray diffraction of the aforementioned copper layer having a ratio of the (200) peak strength to the sum of the main six peak strengths { (200) peak strength / ( sum of (111), (200), (220), (311), (400), and (331) peak strengths) } of at least 0.4. Furthermore, the copper electrolyte for forming the aforementioned copper layer is characterized by including as an additive at least one of chloride ions, thiourea, a thiourea derivative, and thiosulfuric acid.

Provided is a silver-plated coated body that is excellent in interlayer adhesion and tarnish resistance. The silver-plated coated body has a silver film layer and a topcoat layer as essential layers on a substrate, the topcoat layer containing at least one kind selected from thiourea and thiourea derivatives, and at least one kind selected from thiol organic acids and thiol organic acid derivatives.

The invention provides an ether-based double-sulfur amine ester derivative or an ether-based bis-thiourea derivative and a preparation method and application thereof. The molecular structure of the ether-based double-sulfur amine ester derivative or the ether-based bis-thiourea derivative contains a large quantity of thioamide or thiourea or thioacid amide ether or other lipophilic groups and carboxyl hydrophilic groups. The preparation method includes the steps that bis-chloro-carbonic ester and thiocyanate are subjected to a substitution reaction, an intermediate product containing bis-acyl bis-isothiocyanate is generated, the intermediate and an alcohol compound or an amine compound or a phenol compound are subjected to an addition reaction, and then the ether-based double-sulfur amine ester derivative or the ether-based bis-thiourea derivative is obtained. The preparation method is simple, the prepared product directly serves as a non-molybdenum sulphide ore inhibitor, and floatation separation of molybdenum sulfide ore and the non-molybdenum sulphide ore can be effectively achieved. The preparation method is especially suitable for separation of molybdenite and copper sulphide ore, galena, sphalerite, pyrite, arsenopyrite, jamesonite concentrate, nickel sulfide ore, bismuth sulfide ore and the like, and the grade of molybdenum concentrate is improved.

The present invention relates to novel Heterocyclic Urea and Thiourea Derivatives of formula (I), compositions comprising the Heterocyclic Urea and Thiourea Derivatives, and methods for using the Heterocyclic Urea and Thiourea Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.

The invention discloses an N-substituted pyridine acyl-N-substituted pyrimidyl thiourea derivant, a preparation method thereof and application of the N-substituted pyridine acyl-N-substituted pyrimidyl thiourea derivant as a bactericide. The invention provides a new N-substituted pyridine acyl-N-substituted pyrimidyl thiourea derivant, as well as the preparation method and the application thereof. The provided N-substituted pyridine acyl-N-substituted pyrimidyl thiourea derivant has excellent bactericidal activity.

The present application discloses compounds of formula (I) wherein X is ═O, ═S, ═NH, ═NOH and ═NO-Me; A is —C(═O)—, —S(═O)2—, —C(═S)— and P(═O)(R5)—; B is, —O—, —(CH2)3-6—, and O—(CH2)2-5—; D is, —O—, —CR7R8— and —NR9; m is 0-12, n is 0-12, m+n is 1-20; p is 0-4; R1 is opt.sub. heteroaryl; and pharmaceutically acceptable salts thereof, and prodrugs thereof. The application also discloses the compound for use as a medicament for the treatment of a disease or a condition caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPRT), e.g. inflammatory and tissue repair disorders; dermatosis; autoimmune diseases, Alzheimers disease, stroke, athersclerosis, restenosis, diabetes, glomerulonephritis, cancer, cachexia, inflammation associated with infection and certain viral infections, including Acquired Immune Deficiency Syndrome (AIDS), adult respiratory distress syndrome, ataxia telengiectasia.

The invention discloses polyurethane-modified daub for leaking stoppage. The daub comprises a component A, a component B and a component C in the total weight part ratio being 100: (40-60): (5-20), wherein the component A is prepared from polyurethane-modified epoxide resin, mica powder Al2O3 and diethylene glycol; the component B is prepared from diethylenetriamine, a single epoxy compound, a DMP (dimethyl phthalate)-30 catalyst and colloidal graphite; the component C is prepared from thiourea or a thiourea derivative, CaO and / or Ca(OH)2 and 8-hydroxyquinoline. Compared with the prior art, the provided polyurethane-modified daub for leaking stoppage has good toughness, can effectively prevent propagation of cracks in a pipe, guarantees the repairing effect and can stop leakage at the temperature and under pressure, cracks of equipment can be prevented through coating in advance, the curing speed of the daub in winter is high, the material is environment-friendly, no side effects and odors are produced, and the operation safety is good.

The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.

A two-component initiator system having accelerators for curing polymerizable materials comprising the following components: (a) a hydroperoxide compound containing one or more hydroperoxide groups that are bound to a tertiary carbon; (b) a thiourea derivative; and (c) as accelerator, a copper compound which is soluble in the preparation is preferably free of amine and is particularly suited for polymerizable dental compositions.

The invention relates to a motor vehicle antifreeze fluid additive with high corrosion inhibition performance and a preparation method thereof and belongs to the technical field of antifreeze fluid. The motor vehicle antifreeze fluid additive is prepared from, by weight, 5-10 parts of ammonium nitrate, 3-5 parts of sodium pyrophosphate, 2-4 parts of sodium phosphate, 1-2 parts of sodium molybdate benzene, 1-3 parts of benzotriazole, 0.5-1 part of itaconic acid homopolymer, 0.1-0.3 part of methyl benzotriazole, 0.1-0.3 part of polyoxyethylene alkylphenol ether, 0.2-0.4 part of thiourea or thiourea derivative, 0.1-0.3 part of mildew preventive, 0.2-0.4 part of hydrocarbon imidazoline quaternary ammonium salt and 0.5-1 part of nonionic surfactant. Amine, borax and silicate are not added to the antifreeze fluid additive, environment is not influenced, the problem of scaling is avoided, the freezing point is low, and good corrosion resistant performance is achieved.