The invention provides a composition containing a mixture of a first phenyl-carbamoyl thiazole derivative and a second phenyl-carbamoyl thiazole derivative which are different from each other. Together with extracts of plants such as crotalaria assamica, star anise fruits, calophyllum membranaceum, schisandrae virides caulis, cycas leaves and the like, the mixture can generate synergistic antibacterial action on staphylococcus hominis, pantoea agglomerans, kocuria kristinae, serratia liquefaciens, ralstonia pickettii, peptostreptococcus anaerobius, klebsiella oxytoca, corynebacterium macginleyi, listeria monocytogens, simulation corynebacterium, clostridium perfringens, staphylococcus haemolyticus, aeromonas hydrophila, acinetobacter baumannii, streptococcus sanguis, peptostreptococcus prevotii, propionibacterium acnes, pseudomonas oryzihabitans, staphylococcus warneri, and legionella pneumophila.