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Application of fosfomycin trometamol to preparation of drug for treating chronic bacterial prostatitis

A technology of fosfomycin trometamol and prostatitis, which is applied in the field of application of fosfomycin trometamol in the preparation of drugs for the treatment of chronic bacterial prostatitis, can solve the problems of prostatitis that cannot be cured, and achieve the goal of taking medicine for patients Good compliance, less adverse reactions, and definite curative effect

Active Publication Date: 2013-08-28
SHENYANG NO 1 PHARMA FACTORY DONGBEI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is precisely because the prostate is surrounded by a very dense lipid envelope of the prostate, and the inflammation of the prostate occurs inside the prostate. General medicines cannot penetrate this dense envelope at all, and the drug ingredients can only be in the Active around the glands of the prostate to eliminate some of the surrounding inflammation, which is the main reason why prostatitis treatment drugs can only relieve symptoms but cannot cure prostatitis

Method used

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  • Application of fosfomycin trometamol to preparation of drug for treating chronic bacterial prostatitis
  • Application of fosfomycin trometamol to preparation of drug for treating chronic bacterial prostatitis
  • Application of fosfomycin trometamol to preparation of drug for treating chronic bacterial prostatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] drug efficacy test

[0015] 1. Materials and methods

[0016] 1.1 General information: There were 117 patients in this group, aged 18 to 52 years, with an average of 34.5 years. The course of disease is 2 months to 5 years. The main clinical manifestations are:

[0017] (1) Different degrees of urinary frequency, urgency, feeling of incomplete urination, hesitancy to urinate, strenuous urination, dripping white and other urination symptoms;

[0018] (2) Pain and discomfort in the suprapubic area, perineum pain, penis pain, and ejaculation pain;

[0019] (3) Routine urine examination before treatment was normal, white blood cells > 10 / HP in prostate massage liquid microscopic examination, positive for VB3 and EPS bacterial culture by Meares-stamey four-cup test, confirmed as type II prostatitis and included in this study.

[0020] 1.2 Treatment method: apply 1 bottle of fosfomycin tromethamine powder (produced by Northeast Pharmaceutical Group Shenyang No. 3 h 7 o ...

Embodiment 2

[0043] Fosfomycin trometamol granules prescription (100 unit doses)

[0044]

[0045] Among them, the fragrance is selected from strawberry flavor, blueberry flavor, banana flavor, apple flavor, cantaloupe flavor, peach flavor, bayberry flavor, sour plum flavor, orange flavor, pineapple flavor, orange flavor, grape flavor, taro flavor, coconut flavor , lemon flavor, lychee flavor, stevioside, watermelon flavor, mango flavor, blackcurrant flavor or one or more; sweeteners are selected from sodium saccharin, sucralose, cyclamate, sucrose, glucose, maltose, One or more of sweetener and xylitol. The binder is selected from one or more of methylcellulose, ethylcellulose, carboxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, and sodium carboxymethylcellulose.

[0046] Preparation

[0047] Thoroughly mix fosfomycin trometamol, essence and sweetener, add 30% ethanol solution or a proper amount of binder solution, pass through a 24-mesh sieve to granulate, dr...

Embodiment 3

[0049] Fosfomycin trometamol powder prescription (100 unit doses)

[0050]

[0051] Among them, the fragrance is selected from strawberry flavor, blueberry flavor, banana flavor, apple flavor, cantaloupe flavor, peach flavor, bayberry flavor, sour plum flavor, orange flavor, pineapple flavor, orange flavor, grape flavor, taro flavor, coconut flavor , lemon flavor, lychee flavor, stevioside, watermelon flavor, mango flavor, blackcurrant flavor or one or more; sweeteners are selected from sodium saccharin, sucralose, cyclamate, sucrose, glucose, maltose, One or more of sweetener and xylitol. The binder is selected from one or more of methylcellulose, ethylcellulose, carboxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, and sodium carboxymethylcellulose.

[0052] Preparation

[0053] Sieve fosfomycin tromethamine directly (80 mesh), or thoroughly mix fosfomycin tromethamine with one or more of flavors, sweeteners, and binders and sieve (80 mesh ), the ...

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Abstract

The invention discloses an application of fosfomycin trometamol to the preparation of a drug for treating chronic bacterial prostatitis in the field of chemical drug applications. The chronic bacterial prostatitis goes with bacterial infection in seminal fluid; bacteria include one or more selected from staphylococcus epidermidis, staphylococcus aureus, Escherichia coli, streptococcus agalactiae, streptococcus faecium, streptococcus viridans, enterococcus faecalis and staphylococcus haemolyticus; the drug is an oral drug; the oral drug is in a form of powder, granules, dry suspension or effervescent tablets; 5.631g of fosfomycin trometamol is contained in the unit dose of the oral drug; the chronic bacterial prostatitis goes with a pain and discomfort symptom and a micturition symptom; and the pain and discomfort symptom includes one or more selected from suprapubic swelling pain and discomfort, perineum pain, phallalgia pain and ejaculation pain. In the new application, the product disclosed by the invention is exact in curative effect, few in adverse effects and good in compliance of patient in taking a medicine.

Description

technical field [0001] The invention relates to a new application of fosfomycin trometamol in the application field of chemical drugs, in particular to an application of fosfomycin trometamol in the preparation of medicines for treating chronic bacterial prostatitis. Background technique [0002] Fosfomycin trometamol, English name Fosfomycin Trometamol, chemical name (2-R-cis-)-(3-methyloxiranyl) phosphate mono-(trihydroxymethyl)-methylamine salt, molecular formula for C 7 h 18 NO 7 P, structural formula see figure 1 . Fosfomycin tromethamine is an antibiotic drug, which is the tromethamine salt of fosfomycin. Fosfomycin trometamol is well absorbed orally, with higher concentrations in the liver and kidneys. Healthy people take this product at a dose of 50 mg / kg, and the blood concentration reaches a peak value 2 hours after taking it, which is 35.6 mg / L, which is 4.4 times that of fosfomycin calcium, and the half-life is 3 hours. This product is mainly excreted by t...

Claims

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Application Information

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IPC IPC(8): A61K31/665A61P31/04A61P13/08
CPCY02A50/30
Inventor 商学军张琪费继东邢丹王园园赵颖梅刘辉周联波何新
Owner SHENYANG NO 1 PHARMA FACTORY DONGBEI PHARMA GRP
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