69 results about "Bacterial prostatitis" patented technology

A composition and a method for treatment of prostate related dysfunction and, particularly, non-bacterial prostatitis and, even more particularly, non-bacterial chronic prostatitis. The composition primarily relies upon the use of a bioflavonoid and, particularly, that bioflavonoid known as quercetin. The quercetin is mixed with a proteolytic digestive enzyme protease, such as bromelin and papain, as the primary active ingredients. However, the composition may optionally and beneficially include other prostatitis affecting agents, such as zinc derived from zinc gluconate, cranberry, saw palmetto, as well as some other active and non-active ingredients.

The invention discloses medicinal application and an extracting method of shorthorned epimedium P.E, belonging to the field of medicines. The shorthorned epimedium P.E containing icariin, icariin A, icarisid II and epimedin B is applied to preparing medicines for treating chronic bacterial prostatitis, chronic nonbacterial prostatitis and hyperplasia of the prostate. The preparation method comprises the following steps: adding water or ethanol to epimedium for extraction; concentrating the extracting solution until the relative density is 1.01-1.10 at the temperature of 70 DEG C; and refining the filter liquor by a polyamide adsorption method, thus obtaining the shorthorned epimedium P.E. The invention has the following beneficial effects: by comparing data obtained in pharmacological tests with the data in related documents and patents, the medicines for treating chronic prostatitis and chronic hyperplasia of the prostate, which are prepared from the ehorthorned epimedium P.E, have definite curative effect, have no side effects and also have treatment effect superior to that of the prior art.

The invention discloses a preparation method of a blaps rynchopetera fairmaire alcohol extract, and relates to the field of medicine processing. The preparation method of the blaps rynchopetera fairmaire alcohol extract comprises the following steps: soaking a blaps rynchopetera fairmaire living body with 95% ethanol; taking out polypide, airing and crushing the polypide, soaking the powder with 95% ethyl alcohol, 70% ethyl alcohol and 60% ethyl alcohol for 72 hours respectively, and continuously soaking the powder for three times; and recovering filtrate, concentrating the filtrate and carrying out freeze-drying to form freeze-dried powder, namely the medicine. A nonbacterial prostatitis model of a rat is copied with a chemical inflammatory agent carrageenan. Administration is carried out after the model is copied successfully; the treatment effect of the blaps rynchopetera fairmaire on the nonbacterial prostatitis model of the rat is obtained through comparison with a positive medicine and a blank group; and the treatment effect of the medicine is obvious.

A depressant of capsaicin-sensitive sensory nerve, containing quinuclidin-3′-yl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate or a salt thereof as an active ingredient, specifically a therapeutic drug of interstitial cystitis, hypersensitive disorder of the lower urinary tract, and / or abacterial prostatitis.

A composition and a method for treatment of prostate related dysfunction and, particularly, non-bacterial prostatitis and, even more particularly, non-bacterial chronic prostatitis. The composition primarily relies upon the use of a bioflavonoid and, particularly, that bioflavonoid known as quercetin. The quercetin is mixed with a proteolytic digestive enzyme protease, such as bromelin and papain, as the primary active ingredients. However, the composition may optionally and beneficially include other prostatitis affecting agents, such as zinc derived from zinc gluconate, cranberry, saw palmetto, as well as some other active and non-active ingredients.

The present invention relates to the association between detecting and quantifying the presence of macrophage migration inhibitory factor (MIF) in urine, bladder and prostate tissues for the purpose of diagnosis and prognosis of urological inflammatory. In addition, methods to inactivate MIF activity by use of antibodies or specific MIF inhibitors can be used to treat these diseases. For instance, such diseases as chronic pelvic pain syndrome, non-bacterial prostatitis, and interstitial cystitis may be mediated by MIF release. Periodic assays for MIF could be conducted for a patient to determine if the patient's MIF urine levels are high or increasing. In addition, intravesical MIF antibodies or other MIF-specific inhibitors would reduce or ameliorate these pelvic diseases.

A depressant of capsaicin-sensitive sensory nerve, containing quinuclidin-3′-yl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate or a salt thereof as an active ingredient, specifically a therapeutic drug of interstitial cystitis, hypersensitive disorder of the lower urinary tract, and / or abacterial prostatitis.

The invention relates to the field of a traditional Chinese medicine, and discloses a traditional Chinese medicine for treating chronic bacterial prostatitis. The traditional Chinese medicine is prepared from astragalus mongholicus, radix achyranthis bidentatae, felwort, semen vaccariae, lumbricus, polygonum cuspidatum, cordate houttuynia, herba patriniae, herba lycopi, pangolin beads, spina gleditsiae, dandelion, golden cypress, licorice and rheum officinale. The traditional Chinese medicine for treating the chronic bacterial prostatitis disclosed by the invention is good in a curative effect, short in treatment course, and high in recovery rate; and the total effective rate is 97.69%.

[Problems] A compound useful as an active ingredient for a pharmaceutical composition for treating FAAH-related diseases is provided.[Means for Solution] The present inventors have made extensive studies on compounds having an FAAH inhibitory activity, and as a result, have found that a piperazine-1-carboxylate compound, in which benzimidazol-2-ylcarbonyl, benzofuran-2-ylcarbonyl or the like binds to the 4-position of the piperazine, has an excellent FAAH inhibitory activity and further has an action to increase the effective bladder capacity, an action to ameliorate sleep disorders, an anti-diuretic action, and an analgesic activity on lower urinary tract pain including bladder pain and the like, thereby completed the present invention. The carbamate compound of the present invention has an excellent FAAH inhibitory activity and can be used as an agent for preventing and / or treating FAAH-related diseases, particularly nocturia, interstitial cystitis, painful bladder syndrome, or chronic non-bacterial prostatitis / chronic pelvic pain syndrome.

Disclosed is a compound useful as an active ingredient for a pharmaceutical composition for treating FAAH-related diseases. Extensive studies have been made on compounds having an FAAH-inhibiting activity, and it is confirmed that a piperazine-1-carboxylate compound having a benzimidazol-2-ylcarbonyl, a benzofuran-2-ylcarbonyl or the like bound to position-4 in the piperazine moiety has an excellent FAAH-inhibiting activity and has an activity to increase the effective bladder capacity, an activity to ameliorate sleep disorder, an anti-diuretic activity and an analgesic activity on lower urinary tract pain including bladder pain. The carbamate compound has an excellent FAAH-inhibiting activity and can be used as a prophylactic and / or therapeutic agent for FAAH-related diseases, particularly nycturia, interstitial cystitis, painful bladder syndrome or chronic non-bacterial prostatitis / chronic pelvic pain syndrome.

The invention relates to Chinese medicinal adhesive plaster, in particular to a preparation method, a detection index, a detection range and application thereof in the preparation of a medicament for treating chronic non-bacterial prostatitis, which belong to the field of medicaments. The Chinese medicinal adhesive plaster is prepared from the following raw materials in part by weight: 200 to 800 parts of turmeric, 200 to 800 parts of golden cypress, 200 to 800 parts of rheum officinale, 50 to 400 parts of rhizoma atractylodis, 50 to 400 parts of magnolia bark, 200 to 800 parts of radix angelicae, 50 to 400 parts of liquorice, 50 to 400 parts of pericarpium citri reticulatae, 50 to 400 parts of rhizoma arisaematis, 500 to 1,500 parts of radix trichosanthis, 50 to 400 parts of beewax, 10 to 70 parts of peregal and 20 to 100 parts of natural rubber. The invention also relates to application of the Chinese medicinal adhesive plaster of the components in the preparation of the medicament for treating the chronic nonbacterial prostatitis. The Chinese medicinal adhesive plaster can be externally applied and is used for treating the chronic nonbacterial prostatitis and has the advantages of exact curative effect and high safety.

The present invention discloses the application of Chinese lizardtail herb and its derivative in preparing medicine, health article and compound preparation for preventing and treating prostatosis and its complication. Clinical application shows that Chinese lizardtail herb and its derivative has obvious curative effect on acute and chronic prostatitis and prostate hyperlosia, and Chinese lizardtail herb and its derivative has higher curative effect and less toxic side effect compared with Qianliekang tablet. Animal experiment shows that Chinese lizardtail herb and its derivative can eliminate prostate weight increment and swelling of rat caused by Xiaozhiling injection, remit inflammatory cell infiltration and damage, suppress fibrous tissue hyperplasia and treat abacterial prostatitis as well as treat prostate hyperplosia caused by Testosterone Propionas.

The present invention discloses a method used for extracting and purifying osthole from Chinese medicine of selinum by water-bearing ethanol, an appropriate amount of calcium hydroxide or calcium oxide, and other agents. The present invention also relates to oral taking preparations that are made of the osthole, and the application of preventing the proliferation of prostatic gland and non-bacterial prostatitis.

A method for preparing ofloxacin sustained-release capsules comprises steps of preparing materials, mixing, preparing pills, coating and filling into capsules. In the coating process, granules do not easily fall off and coating liquid is easily attached so that sustained-release function can be achieved and medicine can be relatively well released. By employing the ofloxacin sustained-release capsules prepared by the method, experiments show that, absorption in vivo is slowed down, shape of a blood concentration-time curve becomes relatively flat, sudden release is avoided, and the ofloxacin sustained-release capsules can keep blood concentration remarkably superior to the conventional ofloxacin tablets and has sustained-release function. The ofloxacin sustained-release capsules are used for treating adult sensitive strain-induced urinary tract infections and genitourinary tract infections comprising simple urinary tract infections, complex urinary tract infections, bacterial prostatitis, gonococcal urethritis, cervicitis, intrauterine infections, appendagitis, etc.

The invention discloses the application of phytosterin in preparing medicamnet for the treatment of chronic non-bacterial prostatitis and a medicament composition. The phytosterin mainly contains beta-sitosterin, stigmasterol, campesterol and or brassicasterol. The medicament composition of the invention is common tablet, capsule, granule, injection or slow-release tablet and capsule. The invention has excellent functions of anti chronic non-bacterial prostatitis, high security, and is clinically used for the treatment of chronic non-bacterial prostatitis.

The invention provides flushing fluid for an electrocision and an application of the flushing fluid. The solute of the flushing fluid is quinolone or nitroimidazole drug; the solvent is sodium chloride solution; the concentration of the solute is 0.01 to 50 g / L; the concentration of the sodium chloride is 0.5 to 100 g / L; the quinolone antibiotics contained in the flushing fluid for the electrocision has high antibacterial activity to a plurality of gram negative bacteria and gram positive bacteria, strong function and small side effect; and the nitroimidazole drug has a strong bacterium resisting effect to bacterial cystitis, and has short period of treatment, high curative effect and less untoward effect. The flushing fluid for the electrocision, provided by the invention, can perform bacterium resisting treatment while the electrocision is performed; and the drug is led in through direct current, so that drug ions can reach the position 10 to 15 mm below the skin tissue, has good effect to patients suffering from hyperplastic prostate and accompanied with bacterial prostatitis or cystitis and can prevent residual infection.

The invention discloses a novel application of aescin and salt thereof in pharmacy, in particular relates to the novel application of aescin and salt thereof in preparing alpha-blocker medicaments and medicaments for treating chronic abacterial prostatitis. Pharmacodynamic experiment results indicate that aescin and salt thereof can be used for reducing the prostate organ coefficient of a rat model with chronic abacterial prostatitis caused by an estradiol benzoate injection, reducing the number of leukocytes in the prostate of the rat model with chronic abacterial prostatitis, and improving the density of the lecithin body in the prostate of the rat model. Clinical testing results indicate that the aescin and salt thereof can be used for relaxing prostate and bladder smooth muscle and have effects similar to alpha-blocker (bensylyt), the total effective rate of the aescin and salt thereof for treating chronic abacterial prostatitis is 88.33 percent, which is superior to that of the alpha-blocker bensylyt, and no remarkable adverse response is found.

The invention provides an extract of total flavonoids of coromandel coast falsemallow. The weight percent content of the total flavonoids is no less than 1% by taking the weight percent of rutin as a reference. The invention further provides a preparation method and an application of the extract. The extract is stable and controllable in quality as well as simple and feasible in extraction process and cannot perform pollution on the environment, thereby being suitable for large-scale extraction. The extract is used for treating prostatic diseases, and particularly has definite and safe medicinal effects for treating prostatic hyperplasia, prostatitis, prostatic cancers and abacterial prostatitis, thereby providing a new medicine selection for clinical applications.

This invention relates to an agent for preventing or treating chronic pelvic pain syndromes (chronic abacterial prostatitis, chronic pelvic pain syndrome in a narrow sense and interstitial cystitis), which comprises various phosphodiesterase 4 (PDE 4) inhibitors such as cilomilast and roflumilast as an active ingredient.

The invention relates to a traditional Chinese medicine composition for treating chronic abacterial prostatitis and belongs to the field of traditional Chinese medicine compositions. The traditional Chinese medicine composition for treating chronic abacterial prostatitis has a low cost and definite therapeutic effects. The traditional Chinese medicine composition comprises 70-90g of plantain herb, 20-40g of raw rheum officinale, 20-40g of giant knot weed, 20-40g of corydalis tuber, 40-60g of radix sophorae flavescentis, 40-60g of cortex phellodendri, 40-60g of rhizoma smilacis glabrae, 40-60g of fructus forsythiae and 90-110g of coptis root.

The present invention provides an animal model for use in the development of a preventive or therapeutic agent for human chronic nonbacterial prostatitis, in particular a nonbacterial prostatitis nonhuman animal model mimicking the pathology of human chronic nonbacterial prostatitis. The nonbacterial prostatitis animal model is prepared by injecting hydrochloric acid beneath the prostatic capsule and exhibits prostate tissue damage and lower urinary tract disorders that are characteristically observed in human chronic nonbacterial prostatitis.

The invention discloses an extract of diterpene-containing white flower cacalia seeds, an extracting method of the extract and an application of the extract. The extracting method includes the steps: drying the white flower cacalia seeds, crushing, sieving, extracting by alcoholic solution, and filtering to obtain total white flower cacalia seed alcohol extracting solution; performing decompression and concentration for the total white flower cacalia seed alcohol extracting solution to constant weight to obtain paste; sequentially extracting by cyclohexane and ethyl acetate to obtain an ethyl acetate extract. The ethyl acetate extract is the diterpene-containing white flower cacalia seed extract. The extract verifies that the extract of the white flower cacalia seeds containing ditepenoid compounds has good function of resisting chronic nonbacterial prostatitis. The white flower cacalia seeds are wide in distribution and easily obtained, the extract of the diterpene-containing white flower cacalia seeds is applied to preparation of medicines for preventing and treating chronic prostatitis, and a preparation method is simple and low in cost and meets development requirements of the medicines.

The invention discloses a fatty acid extract of rape pollen as well as a preparation method and an application of the fatty acid extract. The preparation method of the fatty acid extract of the rape pollen comprises steps as follows: step one, the rape pollen is extracted with water, solid pollen matters obtained after water extraction are retained; step two, the solid pollen matters obtained in the step one are extracted in a supercritical CO2 extraction device, and a supercritical extract of the rape pollen is obtained; step three, the supercritical extract of the rape pollen is extracted with an ethanol solution, and an ethanol extract of the rape pollen is obtained; the ethanol extract of the rape pollen is filtered and concentrated, and the fatty acid extract of the rape pollen is obtained. The fatty acid extract of the rape pollen and enriched effective substances of the rape pollen are mixed in the weight ratio being (1:1)-(12:1), and medicine composition is prepared. The fatty acid extract of the rape pollen or the medicine composition can be used for treating benign prostatic hyperplasia or chronic nonbacterial prostatitis.

The invention provides a traditional Chinese medicine mixture for treating non-bacterial prostatitis. The traditional Chinese medicine mixture is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 5-10 parts of cassia twig, 1-5 parts of asarum, 10-25 parts of yam rhizome, 5-10 parts of lindera aggregata, 8-15 parts of fennel, 10-25 parts of beautiful sweetgum fruit, 10-25 parts of salvia miltiorrhiza, 15-30 parts of tangerine seed, 3-8 parts of rhizoma anemarrhenae, 3-10 parts of cortex phellodendri, 15-30 parts of prepared fleece flower root, 10-25 parts of dogwood, 5-15 parts of radix rehmanniae, 5-15 parts of radix rehmanniae preparata, 10-25 parts of calamus, 10-30 parts of poria cocos, 10-25 parts of alisma, 10-25 parts of cortex moutan, 5-15 parts of rhizoma cimicifugae, 10-25 parts of radix achyranthis bidentatae and 5-10 parts of licorice. All the medicines of the traditional Chinese medicine mixture are compatible with each other and complement each other; the traditional Chinese medicine mixture has the effects of clearing away heat and toxic materials, resisting bacteria, eliminating inflammation, activating blood circulation to dissipate blood stasis, replenishing blood, nourishing yin, promoting qi circulation, relieving pain, clearing damp, promoting diuresis, activating blood to promote menstruation, dissolving lumps, resolving masses and tonifying kidney to control nocturnal emission and the like. All the medicines of the traditional Chinese medicine mixture have synergistic effects. When being used for treating non-bacterial prostatitis, the traditional Chinese medicine mixture has the characteristics of treating both manifestation and root causes of diseases, having an obvious curative effect, being low in treatment cost, having no toxic or side effect and the like.

The invention discloses an application of quercetin in preparation of a drug for treating CP (chronic prostatitis) and a drug which is used for treating nonbacterial prostatitis and has the active component of quercetin. It is found that the quercetin can reduce the prostate index and reduce infiltration of inflammatory cells in prostate mesenchyme on the premise that the body weight is not affected, which indicates that the quercetin has the significant inhibition effect on the CP in histology; the quercetin can significantly reduce levels of inflammatory cell factors IL-1beta, IL-2, IL-6 andTNF-alpha in prostatitis tissue, which proves that the quercetin has the significant anti-inflammatory function on the CP; the quercetin can significantly improve antioxidant enzyme activity in bodies and reduce production of oxidative stress products, which indicates that the quercetin has the significant antioxidation effect on the CP. The results prove that the quercetin has significant treatment effects on the CP, and the foundation is laid for development of clinical drugs.

The present invention discloses a chronic nonbacterial prostatitis treating pharmaceutical composition, which comprises a traditional Chinese medicine extract and a pharmaceutical adjuvant, wherein the traditional Chinese medicine extract is prepared by carrying out water extraction and alcohol precipitation on the following raw materials by weight: 19-30 parts of pyrrosia lingua, 10-17 parts of dioscorea septemloba thunb, 8-13 parts of dipsacus asper stir-fried with salt-water, 8-13 parts of fried sophora flower, 19-30 parts of coix seed, 6-12 parts of cornus officinalis, 3-5 parts of cinnamomum cassia presl, 5-9 parts of fructus viticis, and 5-9 parts of xanthoceras sorbifolium bunge. According to the present invention, the total effective rate of the chronic nonbacterial prostatitis treating effect of the pharmaceutical composition is high, and the adverse reactions are less.

Disclosed is a prophylactic or therapeutic agent for diseases associated with pains in urinary organs. It is confirmed that a pyridyl non-aromatic nitrogenated heterocyclic-1-carboxylate compound or a salt thereof has an effective bladder capacity increasing activity and also has an analgesic activity on pains in the bladder and the testis, which rely on a FAAH inhibiting activity thereof. Therefore, a pyridyl non-aromatic nitrogenated heterocyclic-1-carboxylate compound or a salt thereof can be used for the prevention or treatment of interstitial cystitis / bladder pain syndrome and / or chronic non-bacterial prostatitis / chronic pelvic pain syndrome.

The invention discloses a traditional Chinese medicine composition for treating prostatitis and an application thereof. The traditional Chinese medicine composition comprises a traditional Chinese medicine extract and pharmaceutic adjuvants, wherein the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 9-15 parts of adenophora tetraphylla, 9-15 parts of semen brassicae, 17-24 parts of Chinese pholidota herb, 10-18 parts of haliotidis concha, 20-30 parts of evening primrose, 20-30 parts of folium turpiniae, 9-15 parts of conyza blinii and 6-10 parts of salix leaf, by means of water extract and alcohol precipitate. The therapeutic action on chronic abacterial prostatitis is achieved by reducing TNF-alpha and IL-8 levels in the prostate tissue of a patient, and the inflammatory reaction degree is reduced; therefore, restoration of a prostate tissue structure is promoted.