Novel application of aescin and salt thereof in pharmacy

A escin and drug technology, applied in the field of new pharmaceutical applications of aescin and its salts, can solve problems such as inability to cure pain, inability to relieve abnormal urination, etc.

Active Publication Date: 2014-07-30
WUHAN AIMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Oral or injection of aescin and its salts are commonly used clinically to treat cerebral edema caused by various reasons and accompanying brain dysfunction, inflammation and swelling caused by various reasons (such as trauma, burns, surgery), and venous reflux disorder It has strong anti-inflammatory and anti-exudation effects, and can significantly reduce the exudation of acute inflammation. However, whether aescin and its salts have the effect of treating chronic non-bacterial prostatitis has not been reported in the literature.
Most of the existing therapeutic drugs are symptomatic treatment. For example, the main function of anti-inflammatory drugs is to relieve pain, but cannot relieve abnormal urination such as urgency, frequency, dysuria, and nocturia; M-receptor blockers are used to relieve urinary symptoms. Urgency, frequent urination and nocturia, but can not cure pain; while antibiotics are mainly for inflammatory chronic prostatitis, but only about 5% of patients with chronic prostatitis have definite bacterial infection; in contrast, α-receptor blockers For example, phenoxybenzamine hydrochloride and naftopidil can relax the smooth muscles of the prostate and bladder and improve lower urinary tract symptoms and pain, so they have become basic drugs for the treatment of chronic non-bacterial prostatitis

Method used

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  • Novel application of aescin and salt thereof in pharmacy
  • Novel application of aescin and salt thereof in pharmacy
  • Novel application of aescin and salt thereof in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 7

[0016] Non-clinical pharmacodynamics study of embodiment 1 aescin sodium

[0017] 1. Experimental materials

[0018] 1.1 Experimental drugs

[0019] Drug: sodium aescinate, white freeze-dried loose block, used 0.9% sodium chloride injection to make sodium aescinate respectively in the experiment, 2.0mg / ml, 1.5mg / ml and 1.0mg / ml solutions .

[0020] Positive control drug: Zhulinamine (phenoxybenzamine hydrochloride tablet), tablet, 5mg / tablet, produced by Henan Tailong Pharmaceutical Co., Ltd. Yuzhong Pharmaceutical Factory. Approval number: Guoyao Zhunzi H10910024.

[0021] Modeling drug: estradiol benzoate injection, produced by Hangzhou Animal Pharmaceutical Factory. Approval number: Veterinary Medicine (2008) 110202511. Specifications: 2ml: 4mg.

[0022] Penicillin Sodium for Injection: Prevention of Inflammation in Rats after Castration, supplied by North China Pharmaceutical Co., Ltd. Specifications: 800,000 units (0.48g).

[0023] 1.2 Experimental animals

[002...

Embodiment 2 7

[0054] The clinical research of embodiment 2 aescin sodium

[0055] 1. Basic information of the case

[0056] A total of 60 outpatients with type Ⅲ prostatitis were recruited, aged from 20 to 55 years old. The longest course of disease was 25 years, and the shortest was 1 year. Some patients had used other therapeutic drugs, but the curative effect was not good. All cases met the inclusion criteria of the study protocol.

[0057] 2. Patient inclusion criteria

[0058] (1) Lower urinary tract symptoms such as frequent urination, urgency, painful urination, poor urination, incomplete urination, increased nocturia, pain and discomfort in the lower limbs, groin area, lumbosacral region, scrotum, testes, and perineum, and even loss of libido, Male outpatients with chronic prostatitis (type Ⅲ) symptoms such as premature ejaculation and ejaculation pain, which last for more than 8 weeks, aged between 20 and 55;

[0059] (2) National Institutes of Health chronic prostatitis symptom...

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Abstract

The invention discloses a novel application of aescin and salt thereof in pharmacy, in particular relates to the novel application of aescin and salt thereof in preparing alpha-blocker medicaments and medicaments for treating chronic abacterial prostatitis. Pharmacodynamic experiment results indicate that aescin and salt thereof can be used for reducing the prostate organ coefficient of a rat model with chronic abacterial prostatitis caused by an estradiol benzoate injection, reducing the number of leukocytes in the prostate of the rat model with chronic abacterial prostatitis, and improving the density of the lecithin body in the prostate of the rat model. Clinical testing results indicate that the aescin and salt thereof can be used for relaxing prostate and bladder smooth muscle and have effects similar to alpha-blocker (bensylyt), the total effective rate of the aescin and salt thereof for treating chronic abacterial prostatitis is 88.33 percent, which is superior to that of the alpha-blocker bensylyt, and no remarkable adverse response is found.

Description

technical field [0001] The present invention mainly relates to the new application of aescin and its salt, in particular to the new application of aescin and its salt in the preparation of α-receptor blocker medicine and the medicine for treating chronic non-bacterial prostatitis. Background technique [0002] Aescin, also known as aescinic acid, is a general term for total saponins, β-aescin or isoescin, which are extracted from the seeds of Aesculus in the family Aesculus. At present, total sodium aescinate is mostly used in clinical practice, which mainly contains 4 kinds of ingredients. According to the national standard of our country, it is named as aescin A, aescin B, aescin C and aescin D successively according to the peak of liquid chromatography. Among them, aescin A and B are β-type aescins, and their structures are basically the same, so aescins A and B can be combined and represented by structural formula (1); and aescins C and D are also isomers of each other,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P13/08A61P29/00
Inventor 刘享平石召华张蕊叶利春王方陈立军
Owner WUHAN AIMIN PHARMA
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