Pharmaceutical use of aescin and its salts
A technology of aescin and medicine, which is applied in the field of pharmaceutical use of aescin and its salts, and can solve problems such as inability to relieve abnormal urination, inability to cure pain, etc.
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Embodiment 1 7
[0016] Non-clinical pharmacodynamics study of embodiment 1 aescin sodium
[0017] 1. Experimental materials
[0018] 1.1 Experimental drugs
[0019] Drug: sodium aescinate, white freeze-dried loose block, used 0.9% sodium chloride injection to make sodium aescinate respectively in the experiment, 2.0mg / ml, 1.5mg / ml and 1.0mg / ml solutions .
[0020] Positive control drug: Zhulinamine (phenoxybenzamine hydrochloride tablet), tablet, 5mg / tablet, produced by Henan Tailong Pharmaceutical Co., Ltd. Yuzhong Pharmaceutical Factory. Approval number: Guoyao Zhunzi H10910024.
[0021] Modeling drug: estradiol benzoate injection, produced by Hangzhou Animal Pharmaceutical Factory. Approval number: Veterinary Medicine (2008) 110202511. Specifications: 2ml: 4mg.
[0022] Penicillin Sodium for Injection: Prevention of Inflammation in Rats after Castration, supplied by North China Pharmaceutical Co., Ltd. Specifications: 800,000 units (0.48g).
[0023] 1.2 Experimental animals
[002...
Embodiment 2 7
[0054] The clinical research of embodiment 2 aescin sodium
[0055] 1. Basic information of the case
[0056] A total of 60 outpatients with type Ⅲ prostatitis were recruited, aged from 20 to 55 years old. The longest course of disease was 25 years, and the shortest was 1 year. Some patients had used other therapeutic drugs, but the curative effect was not good. All cases met the inclusion criteria of the study protocol.
[0057] 2. Patient inclusion criteria
[0058] (1) Lower urinary tract symptoms such as frequent urination, urgency, painful urination, poor urination, incomplete urination, increased nocturia, pain and discomfort in the lower limbs, groin area, lumbosacral region, scrotum, testes, and perineum, and even loss of libido, Male outpatients with chronic prostatitis (type Ⅲ) symptoms such as premature ejaculation and ejaculation pain, which last for more than 8 weeks, aged between 20 and 55;
[0059] (2) National Institutes of Health chronic prostatitis symptom...
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