Composite mequindox injection for treating piglet diarrhea and preparation method of composite mequindox injection
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A technology for the preparation of compound acemequine and injection, which is applied to medical preparations with inactive ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc. Therapeutic effect, cure the root causes but not the symptoms, etc., to relax the smooth muscle of the gastrointestinal tract, treat piglet diarrhea, and increase the solubility
Inactive Publication Date: 2018-11-20
四川兴华药业有限责任公司
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[0005] During the process of diarrhea, piglets excrete a large amount of thin mushy or watery feces, and the piglets quickly develop symptoms of dehydration, functional failure, and death. Methoquine has a good inhibitory effect on pathogenic bacteria, but it cannot quickly control diarrhea symptoms, that is, cure the root cause Not treating the symptoms, it is often difficult to receive a good therapeutic effect when diarrhea emerges
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Embodiment 1
[0019] Embodiment 1: a kind of compound acemethaquine injection for the treatment of piglet diarrhea is formulated by the following raw material components and weight ratio:
[0020] Acetomequine 2kg, benzyl alcohol 15kg, absolute ethanol 40kg, atropine sulfate 0.1kg, sodium bisulfite 0.2kg, water for injection 42.7kg.
[0021] A preparation process for compound acemethaquine injection for treating piglet diarrhea, comprising the following steps:
[0022] 1. Take benzyl alcohol, add acemetquine, stir and dissolve at 45°C, then add absolute ethanol and stir evenly to obtain liquid A.
[0023] 2. Take 10% of water for injection, add atropine sulfate and stir to dissolve completely, then add sodium bisulfite and stir to dissolve completely to obtain liquid B.
[0024] 3. Mix liquids A and B, stir evenly, add water for injection to 99kg, adjust pH to 4.5-6.5, add water for injection to 100kg, stir evenly, filter with 0.45µm filter membrane, fill 10ml ampoule with nitrogen gas, an...
Embodiment 2
[0025] Embodiment 2: a kind of compound acemetquine injection for the treatment of piglet diarrhea is formulated by the following raw material components and weight ratio:
[0026] Acetomequine 5kg, benzyl alcohol 20g, absolute ethanol 50kg, atropine sulfate 0.2kg, sodium bisulfite 0.5kg, water for injection 24.3kg.
[0027] A preparation method for compound acemethaquine injection for the treatment of piglet diarrhea, comprising the following steps:
[0028] 1. Take benzyl alcohol, add acetylmethaquine, stir and dissolve at 45°C, then add absolute ethanol and stir evenly to obtain liquid A.
[0029] 2. Take 10% water for injection, add atropine sulfate and stir to dissolve completely, then add sodium bisulfite and stir to dissolve completely to obtain B liquid.
[0030] 3. Mix liquids A and B, stir evenly, add water for injection to 98kg, adjust pH to 4.5-6.5, add water for injection to 100kg, stir evenly, filter with 0.45µm filter membrane, fill 10ml ampoule with nitrogen g...
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Abstract
The invention discloses a composite mequindox injection for treating piglet diarrhea. The composite mequindox injection is prepared from the following raw material medicine components in parts by weight: 2-5 parts of mequindox, 15-20 parts of phenylcarbinol, 40-50 parts of absolute ethanol alcohol, 0.1-0.2 part of atropine sulfate, 0.2-0.5 part of sodium hydrogen sulfite and 20-45 parts of injection water. A preparation method comprises the following steps: putting mequindox into phenylcarbinol, stirring and dissolving completely at 45 DEG C, and further uniformly stirring with the absolute ethyl alcohol so as to obtain a liquid A; stirring and dissolving the atropine sulfate into 10% of the injection water completely, and further stirring and dissolving sodium hydrogen sulfite completelyso as to obtain a liquid B; mixing the liquid A with the liquid B, uniformly stirring, replenishing the injection water till 98-99% of the total weight, adjusting the pH value to 4.5-6.5, replenishingthe water till 100% of the total weight, uniformly stirring, filtering by using a filtering membrane of 0.45mu m, introducing nitrogen into an ampoule of 10ml, sealing, and sterilizing with circulated vapor at 100 DEG C for 30 minutes, thereby obtaining the composite mequindox injection. Due to scientific matching of the components, and the synergetic effects of the medicines, a good piglet diarrhea treatment effect can be achieved; animal tests show that the composite mequindox injection has a treatment rate up to 92.8% or greater and is low in reoccurrence rate.
Description
technical field [0001] The invention relates to veterinary drugs, in particular to a compound acemetquine injection for treating piglet diarrhea and a preparation process thereof. Background technique [0002] Porcine diarrhea is one of the most common diseases in the pig breeding industry, especially because piglets have not yet established a stable micro-ecosystem in the intestinal tract, their own resistance is low, they are sensitive to external stimuli, and they are particularly vulnerable to various pathogenic microorganisms and various The impact of stress factors leads to diarrhea. If no treatment measures are taken, dehydration, exhaustion, and death will soon occur, causing large economic losses. [0003] Infectious diarrhea is more common in suckling piglets, such as piglet yellow and white scour caused by Escherichia coli, and piglet paratyphoid fever caused by Salmonella; while nursery piglets are caused by non-infectious factors such as dietary antigen allerg...
Claims
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