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Composition and method for treating non-bacterial prostatitis

a prostatitis and composition technology, applied in the field of composition and method for treating nonbacterial prostatitis, can solve the problems of limited effectiveness, no known cure for nonbacterial chronic prostatitis, and therapy often presents frustration to urologists

Inactive Publication Date: 2004-01-08
KATSKE FLOYD A MD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention provides a composition for treating non-bacterial prostatitis through an anti-inflammatory mechanism. The composition includes a bioflavonoid, such as quercetin, which has been found to reduce inflammation in the bladder and prostate gland. The use of quercetin alone has low bioavailability due to low transmural intestinal absorption. However, the combination of quercetin with one or more digestive enzymes, such as bromelain and papain, increases the bioavailability of quercetin and improves the treatment of non-bacterial prostatitis. The composition also includes other herbal ingredients, such as cranberry and saw palmetto, which further enhance the treatment of non-bacterial prostatitis. The composition is made from natural ingredients and is safe and effective in treating non-bacterial prostatitis."

Problems solved by technology

As a result, there is frequently no known cure for non-bacterial chronic prostatitis, although there are several therapies of varying effectiveness, and usually limited effectiveness.
These therapies are generally designed to address the issues of pain and discomfort as well as the other symptoms arising from this condition of prostatitis, but are not specific to any effective cure or permanent treatment therefor.
Subjects having chronic prostatitis refractory to conventional therapies often present frustration to a urologist attempting to treat that condition.
However, very few of the available therapies are effective for treatment of chronic prostatitis, as aforesaid.
However, few patients ever became completely asymptomatic.
However, pain was controlled and the urinary symptoms were only treatable with alpha-blockers or anti-cholinergics.
There is still a great deal of controversy concerning the pathophysiology and the treatment which may be appropriate therefor.
However, where microbial therapy has shown itself to be relatively ineffective, other therapies have used alpha-blockers, anti-inflammatory agents and muscles relaxants.
Nevertheless, these therapies have only met with variable success.
However, this composition is introduced intervesically, usually by means of a catheter and therefore not an effective home use treatment.
Even surgery has been used as a mode of treatment, but the patient frustration with this type of treatment is relatively high.
Today, the incidence of chronic non-bacterial prostatitis appears to be increasing and frequently the available modes of treatment are relatively ineffective or have only limited effectiveness.

Method used

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  • Composition and method for treating non-bacterial prostatitis

Examples

Experimental program
Comparison scheme
Effect test

example i

[0053] A composition having the following ingredients and the weight amounts per dosage set forth in the following Table III, was tested with forty subjects:

3 TABLE III Weight Amount Dosage Quercetin 500 mg Cranberry Powder 10 mg Bromelain 10 mg Papain 10 mg Saw Palmetto 10 mg Zinc 5 mg Black Cohosh 2 mg Scullcap 2 mg Wood Betony 2 mg Valerian Root 2 mg Gelatin 120 mg Magnesium Stearate 19 mg Titanium Dioxide <1 mg FD & C Red 40 <1 mg

[0054] Each of the patients consumed two to four capsules per day and continued using the capsules until the symptoms abated. It was generally found that, in most cases, the symptoms, such as urinary retention, was reduced, urination commencement was eased, and pain associated with the urinary region had been substantially reduced in about two to five days. However, it was found that in most cases when the use of the composition was stopped, there was a re-initiation of the same symptoms. Thus, it is theorized that the anti-inflammatory mechanism provid...

example ii

[0055] A double blind study using 30 patients without positive bacterial cultures localized to the prostatic fluid were enrolled in a double blind study. Seventeen of the patients received a composition comprised cf quercetin in amount of 500 milligrams, bromelain in an amount of 10 milligrams, and papain in an amount of 10 milligrams as the active ingredients thereof. After a randomized study was completed, an additional fifteen patients were treated in an open label study with only the bromelain.

[0056] The fifteen patients which were randomized to quercetin alone completed the study and two of the fifteen patients randomized to the placebo did not because of worsening symptoms. The mean symptom score improved from 21.0 to 13.1 in the group receiving quercetin, but from 20.2 to 18.8 in the placebo group. This represented an improvement of 35%. In those patients which received only the quercetin, without the papain and bromelain, with obtainable extra prostatic secretions, the white...

example iii

[0058] A composition as set forth in the following Table IV was administered to 60 male patients.

4 TABLE IV Weight Amount Dosage Quercetin 500 mg Cranberry Powder 10 mg Bromelain 10 mg Papain 10 mg Black Cohosh 10 mg Scullcap 10 mg Wood Betony 10 mg Saw Palmetto 10 mg Valerian Root 10 mg Zinc 5 mg Other Ingredients: Gelatin 120 mg Magnesium Stearate 19 mg Titanium Dioxide <1 mg FD & C Red 40 <1 mg

[0059] The administration of the tablets again took place at a rate of two to three tablets per day until such time as the symptoms decreased on a per patient basis, much in the same manner as set forth in Example III. It was found in connection with the composition as set forth in Table IV that there was a greater mean improvement in the male patients who took the composition of Table IV, as opposed to the composition of Table III.

[0060] The composition of the invention is preferably useful as a dietary supplement. Moreover, due to the fact that the ingredients used in the composition are ...

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Abstract

A composition and a method for treatment of prostate related dysfunction and, particularly, non-bacterial prostatitis and, even more particularly, non-bacterial chronic prostatitis. The composition primarily relies upon the use of a bioflavonoid and, particularly, that bioflavonoid known as quercetin. The quercetin is mixed with a proteolytic digestive enzyme protease, such as bromelin and papain, as the primary active ingredients. However, the composition may optionally and beneficially include other prostatitis affecting agents, such as zinc derived from zinc gluconate, cranberry, saw palmetto, as well as some other active and non-active ingredients.

Description

[0001] 1. Field of the Invention[0002] The invention primarily relates to a composition and method for the treatment of non-bacterial prostatitis and, more particularly, to a composition and method for treating non-bacterial chronic prostatitis syndromes using bioflavonoids in a treatment composition and in a treatment method.[0003] 2. Brief Description of the Related Art[0004] Prostatitis is a name commonly used for a non-specific group of prostate related problems and is often characterized by prostatic pain, which may actually adopt the form of phantom symptomatic pain. At present, the cause for many of the forms of prostatitis is not fully known. As a result, there is frequently no known cure for non-bacterial chronic prostatitis, although there are several therapies of varying effectiveness, and usually limited effectiveness. These therapies are generally designed to address the issues of pain and discomfort as well as the other symptoms arising from this condition of prostatit...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/352A61K36/45A61K36/539A61K38/48
CPCA61K31/352A61K38/4873A61K2300/00
Inventor KASTKE, FLOYD A.
Owner KATSKE FLOYD A MD
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