The invention discloses a synthesis method of cinnamyl
piperazine. The method includes the steps of: a) adding a
solvent into a reaction kettle and adding
piperazine to uniformly dissolve the
piperazine, dropwisely adding
hydrochloric acid at 20-25 DEG C until the pH of the reaction solution is 2, which is the terminal, and after the reaction is performed for 1 h, cooling the reaction solution to 20 DEG C, and centrifugally spin-filtering the reaction solution to obtain piperazine dihydrochloride; b) adding the
solvent into the reaction kettle, adding the piperazine dihydrochloride and the piperazine with stirring at the same time, and performing a reaction at 68-85 DEG C for 0.5-3 h; c) reducing the temperature to 45-55 DEG C, dropwisely adding cinnamyl
chloride, and then increasing the temperature to 60-75 DEG C to perform a temperature maintained reaction for 1-4 h, and reducing the temperature to 10-35 DEG C, performing
centrifugal separation, sucking a mother liquid into a
distillation reaction kettle, heating the
distillation mother liquid to recycle the
solvent, adding pure water, and dropwisely adding an alkali liquid to regulate the pH to 9-12, and adding
chloroform to perform extraction,
drying the mixture, and evaporate-
drying the
chloroform to obtain the cinnamyl piperazine. The synthesis method reduces production steps and
pollutant emission, and is more suitable for modern industrial production.