69 results about "Rectum Cancers" patented technology

The invention relates to a marker for detecting colon and rectum cancer by utilizing 86 specific ribonucleic acids stably existing in the serum / plasma of a human body, as well as a method, a relevant kit and a biological chip for detecting the marker. The method can be used in the aspects of diagnosing and differentially diagnosing the colon and rectum cancer and predicting the generation and the recurrence of the complications of diseases, evaluating the curative effect, screening the active ingredients in drugs, evaluating the drug effect and the like, and has the advantages of wide detection pedigree, high sensitivity and low detection cost, material is convenient for obtainment, samples are easy to store and the like. The method can be widely used for generally surveying the colon and rectum cancer and relevant work and improving low specificity and low sensitivity which are brought by the individual difference difficultly and are difficult to overcome by the single marker, thereby obviously enhancing the clinical detection rate of the colon and rectum cancer and becoming an effective means for early diagnosing the colon and rectum cancer.

A tetrahydroindolone derivative and its use are disclosed. It can inhibit malignant tumor cell growth. It can be used for mammary gland cancer, lung cancer, uterus neck cancer, rectum cancer, liver cancer and blood cancer.

The flexible cold scalpel probe for freezing treatment of body's cavity tumor includes a probe body of flexible material and possessing inner casing connected with liquid nitrogen cylinder, outer casing covered electric heating element and insulating material and heat insulating jacket with hea tinsulating handle; one temperature sensor between the two casings; one freezing metal head in the front of the probe body filled with porous metal wires; one temperature sensor in the tip of the freezing metal head and with output connected to the data collector; and the data collector connected to a computer. The device has no vacuum structure, small in size, low cost, no inserting damage, adjustable temperature rise and lowering, fast response speed and good continuity and is especially suitable for nasopharyngeal carcinomal, lung cancer, rectum cancer and other cavity tumor.

The invention relates to the measurement for the lipid molecule content in a human blood sample as well as the preparation and the application of a colon cancer or rectum cancer diagnosis reagent kit, in particular to the extraction of lipid molecules in a human blood sample and the content measurement thereof as well as the definition of colon cancer or rectum cancer lipid molecule marks. In addition, the invention also discloses the details about the detection of a few colon cancer or rectum cancer lipid molecule marks in a blood sample and provides a reagent kit which is formed according to the lipid molecule marks and used for colon cancer or rectum cancer diagnosis. According to the content of the lipid molecule marks in the sample, the possibility for a patient suffering the colon cancer or rectum cancer can be diagnosed from the sample through special calculation and analysis, and the invention also provides a new means for the healing efficacy analysis in the colon cancer or rectum cancer treatment.

A Chinese medicine for treating liver cancer, lung cancer, breast cancer, stomach cancer, rectum cancer, and other cancers is prepared from 13 Chinese-medicinal materials including trogopterus dung, leech, toad, cyperus tuber, etc.

The invention relates to a method and kit for detecting gene mutations, particularly a method and kit for detecting KRAS gene 12, 13 codon mutations. The kit comprises a PCR (Polymerase Chain Reaction) buffer solution, a dNTP (deoxyribonucleotide triphosphate), a DNA (deoxyribonucleic acid) polymerase, a specific primer pair, fluorescent dye, water, a specific probe and a wild-type control. The kit is characterized in that the DNA polymerase is a HotStarTaq DNA polymerase, and the fluorescent dye is SYTO9 fluorescent dye. The method comprises the following steps: (1) acquiring a genome DNA to be analyzed according to a conventional method; (2) carrying out PCR amplification on the genome DNA to obtain a PCR amplified product; after the reaction finishes, carrying out denaturation and renaturation on the PCR product; and (3) carrying out melting curve analysis on the PCR amplified product, and comparing with a melting curve generated by the PCR amplified product of the wild-type genome DNA, wherein the melting curve generated by the PCR amplified product of the mutant genome DNA firstly descends.

A laser thermotherapeutic apparatus for treating tumor (gastric cancer, rectum cancer, esophagus cancer, etc) is composed of laser device, transmitting optical fibre, and thermotherapeutic probe in direct contact with tumor. It features that the Nd:YAG (1319nm), Nd:YAP (1341 nm), or semiconductor diode (1310 nm) is used as the laser source as they has weak penetrability and can be easily absorbed by tissue.

We present, in exemplary embodiments of the present invention, a system combining anatomical imaging technologies (e.g., MR) with molecular imaging technologies (e.g., ultrasound). The system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging; (2) image guidance; and (3) radiation therapy planning. Image guidance may include guiding a biopsy. For example, a prostatectomy potentially has severe side effects, such as impotence and incontinence. Thus, a histologically-confirmed diagnosis, such as one provided from a biopsy, may prevent unnecessary prostatectomy. Image guidance may also include guiding minimal invasive therapy, such as brachytherapy focused ultrasound. The present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.

The invention discloses a method for serologically detecting Matrix metalloproteinase 11 (MMP11) and the application thereof. The gene chip technology and the bioinformatics method are adopted to obtain stomach cancer gene expression spectra, and by taking the MMP11 gene for example, the expression characteristics of the gene in the tumor cell lines and tissues are verified at the levels of mRNA and protein. At the same time, a detection kit for the MMP11serum is established by utilizing the technique of the enzyme linked immuno sorbent assay (ELISA), and the expression level of the MMP11 protein in the serum of stomach cancer patients is detected. The level of the MMP11 protein in the serum of stomach cancer patients is obviously higher than that of a non-cancer comparison group (p is lower than 0.001), and the same tendency is also found in the breast cancer, the colon cancer / rectum cancer and the lung cancer. In the serum detection to the stomach cancer patients, the sensitivity of the MMP11 is higher than that of a tumor molecule marker such as CEA, CA199, CA72.4, CA242, etc., and MMP11 and CA199 have good correlation (p is equal to 0.017). Through the analysis of the clinic pathological data, the level of the serum MMP11 has the obvious correlation (p is equal to 0.009) with the cancerometastasis state of the stomach cancer patients. The MMP11 is possible to become a novel tumor serum marker for the diagnosis and the prognostic judgement of the tumors.

The invention discloses a cubilose health-care beverage. The cubilose health-care beverage is characterized by being prepared from following raw materials in parts by weight: 18-20 parts of pleurotus eryngii, 17-20 parts of lilies, 3-5 parts of polygonatum odoratum, 2-3 parts of cyperus rotundus, 15-17 parts of cubilose, 2-4 parts of radix chuanmingshinis violacei, 19-21 parts of celeries, 16-18 parts of white radishes, 12-14 parts of raphanus sativus, 14-16 parts of xylitol, 12-15 parts of vanillin sugar, 13-15 parts of skim milk, 17-19 parts of black rice, 18-20 parts of pineapples, 15-17 parts of pigskin, 14-17 parts of peanut branches and leaves, 4-6 parts of an auxiliary agent and suitable amount of water. The cubilose health-care beverage can be used as a medicine and a food and sufficiently expresses the functions of clearing heat, calming the liver, lowering blood fat and blood pressure, nourishing yin and moisturizing the lung of the celeries; the added cubilose is a natural food for increasing body fluid and contains a plurality of amino acids, so that the cubilose health-care beverage has inhibition and resistance effects on esophagus cancers, pharyngolaryngeal cancers, gastric cancers, liver cancers, rectum cancers and the like.

A Chinese medicine í«Compound telini fly capsuleí» for treating primary liver cancer, lung cancer, rectum cancer, lymph cancer, and gynecologic cancer is prepared from 10 Chinese-medicinal materials including ginseng, telini fly, astragalus root, etc. Its preparing process is also disclosed.

The invention provides fusobacterium nucleatum THCT14E2 which is obtained from large intestine cancer tumor tissue and does not belong to known fusobacterium nucleatum subsp.vincentii. The 16SrRNA gene sequence of the strain is as shown in SEQID NO:1. The classification designation of the THCT14E2 is Fusobacterium nucleatum, the preservation number is CCTCC NO:M 2019361, the preservation date is May 17th, 2019, and the preservation unit is China Center for Type Culture Collection. The colorectal cancer cell line and THCT14E2 co-culture result shows that the THCT14E2 can significantly promote colorectal cancer cell proliferation. Therefore, the THCT14E2 can promote understanding of micro-ecology diversity of rectum cancer, and facilitate function research of the fusobacterium nucleatum fromthe colorectal cancer.

The invention relates to a formula of perfumed soap. The gardenia perfumed soap is prepared from a soap base, gardenia essential oil, herba violae, rhizoma arisaematis and edible ethanol by compounding, wherein gardenias for the gardenia essential oil are bitter cold, can have the effects of entering blood phases, clearing evil heat, easing the intestines, easing constipation and preventing cancer. The gardenias contain cellulose, and can prevent haemorrhoid from being broken down, and rectum cancer tumors from generating. The gardenia perfumed soap is reasonable in formula, good in skin cleaning effect, obvious in sterilizing effect and beneficial for skin health.

An emulsion injection of fluoroplex for treating colon cancer, rectum cancer, stomach cancer, breast cancer and primary liver cancer is proportionally prepared from fluoroplex, plant oil for injection, polyose, emulsifier, isotonic regulator, and the water for injection through dissolving, heating, mixing, emulsifying, cooling and sterilizing.

The invention relates to the field of drug synthesis and discloses a scutellarin prodrug and a preparation method thereof. According to the scutellarin prodrug, cyclodextrin is used as a carrier, and scutellarin molecules are connected with the cyclodextrin through amido bonds formed by carboxyl groups of the scutellarin molecules with amido modified on any hydroxyl group. Compared with scutellarin, the scutellarin prodrug has more hydrophilic active groups, so the biocompatibility and water solubility are better; on the other hand, the scutellarin prodrug has the straight cecum release characteristic and can effectively enter the body of a patient to release the scutellarin at a straight cecum target spot and selectively induce rectum cancer cells of the human body to die, so that the scutellarin is avoided being released and broken in the digestive tract, and the bioavailability is high. The preparation method for the scutellarin prodrug has the advantages of simple operation, easiness of obtaining raw materials and moderate reaction condition and can be used for preparing the scutellarin prodrugs in a large scale.

The present invention relates to conjugate of 3, 7, 10-trisubstituent silatrane and 5-FU, which may be used in preparing medicine for treating leukemia, liver cancer, rectum cancer, gastric cancer, breast cancer and other tumors, and has the structural formula as shown.

The invention relates to tetrahydroindazolone or tetrahydroindazolone-substituted indazole derivatives with right general formula (I) or (II) and pharmaceutically acceptable salt thereof. The compounds and the pharmaceutically acceptable salt thereof are characterized by inhibiting growth of tumor cells and malignant cells. The tumor cells comprise cancer cells such as breast cancer, lung cancer, cervical carcinoma, rectum cancer, prostatic cancer, liver cancer, blood cancer and the like, thus the tetrahydroindazolone or tetrahydroindazolone-substituted indazole derivatives and the salt thereof can be used for preparing drugs for preventing and treating the breast cancer, the lung cancer, the cervical carcinoma, the rectum cancer, the prostatic cancer, the liver cancer and the blood cancer.

The invention discloses active peptide for inhibiting malignant tumors and enhancing treatment effect of chemical drug and application thereof. The active peptide comprises the following sequence, namely Asn-Val-Phe-Thr-Val-Ser-Pro. The active peptide can be applied to specifically inhibit the proliferation, transfer and invasion of cells which are stimulated by fibroblast growth factors, inhibitthe generation of blood vessels, and enhance the therapy effect of the chemical drug, so as to treat various types of malignant tumors which are mediated by the fibroblast growth factors and receptorsthereof and of which the signal channels are abnormally activated, including but not limited to stomach cancer, bladder cancer, breast cancer, ovarian cancer, endometrial cancer, prostatic cancer, lung cancer, esophagus cancer or colon cancer and rectum cancer. The invention also discloses an antitumor medicine containing the active peptide and a preparation method.

We present, in exemplary embodiments of the present invention, a system combining anatomical imaging technologies (e.g., MR) with optical technologies. The system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging; (2) image guidance; and (3) radiation therapy planning. Image guidance may include guiding a biopsy. For example, a prostatectomy potentially has severe side effects, such as impotence and incontinence. Thus, a histologically-confirmed diagnosis, such as one provided from a biopsy, may prevent unnecessary prostatectomy. Image guidance may also include guiding minimal invasive therapy, such as brachytherapy focused ultrasound. The present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.

The invention relate to a traditional Chinese medicine for treating rectum cancer, which is characterized by comprising the following components: 15g of fiverleaf akebia fruit, 9g of radix aucklandiae, 15g of sargentgloryvine stem, 30g of ophiorrhiza pumila, 30g of chinaroot greenbrier, 30g of hairy grape stem, 15g of radix sophorae flavescent, 30g of raw coix seed, 15g of radix salviae miltiorrhizae, 9g of Chinese polyphaga, 9g of dark plum fruit, 30g of snakegourd seed, 30g of solanum lyratum, 15g of pteris vittata L., 30g of rhizoma cyrtomii carbon, 30g of sculellaria barbata and the other Chinese medical herbs. A method for preparing the traditional Chinese medicine for treating rectum cancer comprises the following steps: all the Chinese medical herbs are put in container to be decocted on slow fire for 30 min, and 200 ml of the decoction liquid medicine is taken. One dose of the decoction is taken after the breakfast and the supper every day for ten days in one course of treatment. The preparation is prepared by the Chinese medical herbs with a traditional method, thereby preserving the medicine property of clearing away heat and toxic material, regulating the flow of Qi, dissolving stasis, removing dampness through diuresis, removing obstruction and improve immunity, achieving the purpose of treating rectum cancer and having no side effect.

The invention relates to a medicament for treating cancer and a method for preparing the same. The medicament is prepared by following materials by weight: 20-60 portions of oldenlandia, 30-90 portions of barbat skullcap and 30-100 portion of asparagus. The preparing method is that: washing the oldenlandia and the barbat skullcap; decocting to liquid with water for standby; cooking the asparagus, smashing for standby; drinking the prepared oldenlandia and barbat skullcap liquor, and then taking the smashed asparagus with water, two times a day for 40 g per time. The orally taken health-care medicament can remove pain by diet therapy without any toxicity and side-effect for stomach cancer, rectum cancer, breast cancer, lymphoma, skin cancer, lung cancer, bladder cancer and cervix cancer. The medicament can promote qi and blood circulation, clear away heat-evil and expel superficial evils, diminish the inflammation and reduce the pain, dispel deposit and dissipate binds and remove cancer. The usefulness is high.

The invention provides a human colon cancer extracellular matrix in-vitro model and a preparation method thereof. The model is a freeze-dried sterile porous membrane without cytotoxic substance residues; and in the model, the cell components are completely removed, and the components and structure of the extracellular matrix are completely maintained. The preparation method comprises the following steps: taking a human colon cancer or rectum cancer tissue which is exsomatized within 4 hours, and carrying out pretreatment; sterilizing in a constant-temperature oscillating table by using a low-concentration peroxyacetic acid-ethanol solution; cleaning with a 5-100 mmol / L sodium hydroxide solution in a constant-temperature ultrasonic cleaner with an oscillatory cleaning tank for 30-90 minutes to perform decellularization; putting the material in a freeze drier, and carrying out freeze-drying forming according to a predesigned freeze-drying process; and packaging in a sterile state. According to the method, the colon or rectum cancer extracellular matrix is separated for independent research to construct the model outside the ideal body and inside the animal body for colon or rectum cancer microenvironment and EMT research.

This invention also relates to protein dactylography method for analyzing for the protein group got by retention chromatography. This method adopts mass spectroscopy to distinguish and detect protein group. The analysis data takes the form of bar code (protein dactylography) read by computer. This invention method is used to detect the protein fingerprint in the normal cell, restocarcinoma patient cell and rectal polyp patient cell.

The invention relates to the technical field of traditional Chinese medicine and concretely relates to a combination of traditional Chinese medicine for remedying the rectum cancer. The invention provides a combination of traditional Chinese medicine for remedying the rectum cancer to conquer the problem of the prior art of no effective drug for remedying the rectum cancer. A technical proposal of the invention is a combination of traditional Chinese medicine for remedying the rectum cancer, which is prepared by a ginseng, an angelica, a glossy ganoderma, a rosin, an orange fruit, a dahurain angelica root, a Szechwan lovage rhizome, a cassia twig, a white bark of Japanese pagoda tree root, a lightyellow sophora root, a cow-bezoar, a snow lotus, a muskiness, a pangolin scale, a Chinese honeylocust spine and a hedgehog skin with the equivalent quantity. The combination of traditional Chinese medicine has the advantages of good curative effect, safe and reliable pure traditional Chinese medicinal preparation, being easily for the patient to accept the treatment etc.

The invention relates to an antitumour Chinese medicine preparation for treating tumor. The Chinese medicine is cutin membrane exuviated from hoptoad naturally. In which, the tumor is solid tumor and blood tumor, preferred liver cancer, lung cancer, breast cancer, esophagus cancer, gastric cancer, nasopharyngeal cancer, overian cancer, bladder cancer, rectum cancer, skin cancer and lymphoma, further preferred liver cancer, especially hepatocirrhosis ascites. The cutin membrane agent has an outstanding treating effect to the tumor.

A compound blistering beetle tablet for treating primary liver cancer, rectum cancer, malignant lymphoma and malignant tumor of woman is prepared through pulverizing 4 Chinese-medicinal materials including ginseng, crushing 5 Chinese-medicinal materials including astragalus root, decocting three times, concentrating and spray drying, extracting from Chinese blistering beetle in chloreform, concentracting, grinding bear gall, mixing all together, adding additive, mixing tabletting and coating.

A composite Chinese medicine for treating stomach cancer, esophagus cancer, rectum cancer, lymph cancer, lung cancer, liver cancer, uterine cervix cancer, etc is proportionally prepared from glabrous sarcandra herb and oldenlandia.

A non-fermented frozen dough for preventing constipation, rectum cancer, obesity, coronary sclerosis and cardiovascular disease and decreasing cholesterol is prepared through preparing enzyme solution by dissolving beat-gluconase and pentosanase in water, activating, mixing butter with granular sugar, stirring, adding egg, stirring, adding water, stirring, adding wheat flour, almond skin powder, milk powder, salt, xanthan gum, locust bean gum, etc, stirring, adding said activated enzyme solution, stirring, molding and fast freezing.