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Medical composite prepared by sarcandra and oldenlandia

A technology of Hedyotis diffusa and its composition, applied in the field of medicine, to achieve good anti-tumor effects, prolong life, and meet clinical needs

Inactive Publication Date: 2007-05-02
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on the preparation of anti-tumor drugs by using the interaction of Sargassum and Hedyotis diffusa with compatible prescriptions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0192] The preparation of embodiment 1 sargassum extract

[0193] Preparation:

[0194] Take sargassum, add water to decoct twice, each time for 2 hours, add 10 times the amount of water each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.33 (70°C), add ethanol to precipitate twice, the first The first time the alcohol content is 70%, the second time the alcohol content is 80%, refrigerate for 48 hours each time, filter, the filtrate recovers ethanol and concentrates to contain 10g of crude drug per 1ml, add an appropriate amount of newly prepared egg protein solution, stir , make the precipitate, refrigerate for 48 hours, filter, boil the filtrate, coagulate the excess egg white, filter, add ethanol to the filtrate to make the ethanol content 75%, place the precipitate, filter, recover the ethanol from the filtrate until it has no alcohol smell, The sargassum extract is obtained by spray drying.

[0195] A total of 4 batches wer...

Embodiment 2

[0213] The preparation of embodiment 2 Hedyotis diffusa extract

[0214] Preparation:

[0215] Take Hedyotis diffusa, crush it into a coarse powder, use 80% ethanol as solvent, soak for 24 hours, slowly percolate, and decompress Concentrate until there is no alcohol smell, add water to dilute to an amount equivalent to 1g of the original medicinal material per 1ml, refrigerate, let stand for 12 hours, filter, add ethanol to the filtrate for three gradient alcohol precipitation, the first time to make the alcohol content 60%, the second The first time the alcohol content is 70%, the third time the alcohol content is 80%, each time it is refrigerated for 24 hours, filtered, the filtrate is concentrated under reduced pressure to a relative density of 1.10-1.15, and spray-dried to obtain final product.

[0216] A total of 4 batches were prepared, each batch was 10 kg, and the yield and content determination are shown in Table 9.

[0217] Content determination:

[0218] Preparat...

Embodiment 3

[0224] Embodiment 3 Preparation of the pharmaceutical composition aqueous injection of the present invention

[0225] Prescription one:

[0226] Sargassum Extract 300g

[0227] Hedyotis diffusa extract 20g

[0228] Polysorbate-80 100ml

[0229] Add water for injection to 5000ml

[0230] A total of 1000 sticks were prepared

[0231] Prescription two:

[0232] Sargassum Extract 300g

[0233] Hedyotis diffusa extract 30g

[0234] Polysorbate-80 110ml

[0235] Add water for injection to 5000ml

[0236] A total of 1000 sticks were prepared

[0237] Prescription three:

[0238] Sargassum Extract 300g

[0239] Hedyotis diffusa extract 60g

[0240] Polysorbate-80 150ml

[0241] Add water for injection to 5000ml

[0242] A total of 1000 sticks were prepared

[0243] Preparation Process:

[0244] 1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0245] 2) Take water for inje...

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Abstract

A composite Chinese medicine for treating stomach cancer, esophagus cancer, rectum cancer, lymph cancer, lung cancer, liver cancer, uterine cervix cancer, etc is proportionally prepared from glabrous sarcandra herb and oldenlandia.

Description

[technical field] [0001] The invention relates to a pharmaceutical composition mainly used for treating tumors, in particular to a pharmaceutical composition mainly composed of Sargassum or its extract and Hedyotis diffusa or its extract and a preparation method thereof, which belongs to medicine technology field. [Background technique] [0002] In 2000, there were about 10 million new cancer cases worldwide, 6.2 million deaths, and 22 million existing cases. Cancer is becoming the first killer of human beings in the new century. Since the 1970s, the incidence and mortality of cancer in my country have been on the rise. In the 20 years to the 1990s, the cancer mortality rate increased by 29.42%, and the age-adjusted mortality rate increased by 11.56%. In 2000, the incidence of cancer was about 1.8 to 2 million, and the death toll was 1.4 to 1.5 million. Among urban residents, cancer has taken the first place in the cause of death. At present, the treatment of cancer in mo...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P35/00
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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