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Fluorouracil injecting emulsion and production thereof

A technology of fluorouracil and injection milk, which is applied in the field of emulsion and its preparation, can solve the problems of low bioavailability, unsustainable drug effect, long drug effect time, etc., achieve positive therapeutic effect, promote immune function of the body, and improve curative effect

Inactive Publication Date: 2005-10-12
肖春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the problems of large toxicity and dosage of the above dosage forms, low bioavailability, unsustainable drug effect and high irritation, and provide a drug with low toxicity and irritation, long drug effect time, and long-lasting and targeted low-dose fluorouracil injectable emulsion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Dissolve 4.0g of fluorouracil, 4.0g of ginseng polysaccharide, and 22.5g of glycerin in water for injection, and dissolve 12.0g of refined soybean lecithin in refined soybean oil, respectively heat to 55°C, mix well, and first emulsify fractionally in a tissue masher , and then emulsified by a high-speed homogenizer to meet the particle size of the preparation. Add water for injection to 1000ml, cool, fill, and sterilize to obtain fluorouracil injection emulsion. This process is a 1000ml prescription, and the production can be expanded, and nitrogen protection is required during the production process.

Embodiment 2

[0045] Dissolve 1.0g of fluorouracil and 25.0g of sorbitol in water for injection, dissolve 8g of refined cholesterol in refined corn oil, heat to 40°C respectively, mix well, first fractionally emulsify in a tissue masher, and then pass through a high-speed homogenizer Emulsify to meet the particle size of the preparation. Add water for injection to 1000ml, cool, fill, and sterilize to obtain fluorouracil injection emulsion.

Embodiment 3

[0047] Dissolve 10.0 g of fluorouracil, 10.0 g of astragalus polysaccharide, and 55.5 g of xylitol in water for injection, and dissolve 15.0 g of refined poloxamer in refined sesame oil. Fractionally emulsified, and then emulsified by a high-speed homogenizer to meet the particle size of the preparation. Add water for injection to 1000ml, cool, fill, and sterilize to obtain fluorouracil injection emulsion.

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Abstract

An emulsion injection of fluoroplex for treating colon cancer, rectum cancer, stomach cancer, breast cancer and primary liver cancer is proportionally prepared from fluoroplex, plant oil for injection, polyose, emulsifier, isotonic regulator, and the water for injection through dissolving, heating, mixing, emulsifying, cooling and sterilizing.

Description

technical field [0001] The invention relates to an emulsion for injection and a preparation method thereof, in particular to a fluorouracil injection emulsion for treating cancers such as colon cancer, rectal cancer, gastric cancer, breast cancer, and primary liver cancer and its preparation method. Background technique [0002] Fluorouracil, also known as 5-fluorouracil (5-FU), was developed by Roche Company of Switzerland and Adria Company of the United States, and was first listed in Switzerland in June 1956. It was first registered in China in 1989. As an anti-malignant drug in the DNA synthesis stage, it is mainly used for digestive tract cancer and breast cancer. , bladder cancer also has a certain effect. However, the drug has a lot of side effects, such as gastrointestinal reactions, bone marrow suppression, hair loss and dysfunction. In order to avoid or minimize its adverse reactions, so that it has a targeted or sustained release effect, many scholars have car...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/513A61P35/00
Inventor 肖春
Owner 肖春
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