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Production and use of reagent kit for measurement of lipide molecule content in human blood sample and colorectal carcinoma diagnosis

A colorectal cancer, in-sample technology, applied in measurement devices, material separation, analysis of materials, etc., can solve the problems of high operation requirements, great pain, and patient reduction, and achieve the effect of low cost and less pain

Inactive Publication Date: 2009-08-05
桑建利
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Problems solved by technology

However, the sensitivity and specificity of most currently recommended screening methods are below 50%
Molecular-based genetic testing for colorectal cancer using stool samples has received a lot of attention recently, but the test is only 57% accurate
The sensitivity and specificity of the reported colonoscopy are high, but due to the high cost, great pain and high operation requirements, the patient's willingness to do this examination has been reduced, resulting in many patients being delayed until the late stage and becoming incurable.

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  • Production and use of reagent kit for measurement of lipide molecule content in human blood sample and colorectal carcinoma diagnosis
  • Production and use of reagent kit for measurement of lipide molecule content in human blood sample and colorectal carcinoma diagnosis
  • Production and use of reagent kit for measurement of lipide molecule content in human blood sample and colorectal carcinoma diagnosis

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Embodiment Construction

[0041] In recent years, studies have shown that lysophospholipids in lipid molecules are important cell signal transduction molecules. Lysophospholipid molecules, such as LPA (Lysophosphatidic Acid), S1P (Sphingosine-1-phosphate), LPC (Lysophosphatidylcholine) and SPC (Sphingosylphosphorylcholine), can be produced by cells and secreted extracellularly, and participate in various types of extracellular signaling molecules. Biological activity, therefore known as bioactive lipid molecules. The metabolism of these biologically active lipid molecules is closely related to some biologically active factors such as platelet activating factor.

[0042] LPA is the most studied bioactive lipid molecule in recent years. LPA is involved in a variety of physiological activities, such as brain development, blood pressure regulation, wound healing, sense of smell, and immune and reproductive system functions. At the same time, LPA is closely related to some diseases, especially its role in ...

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Abstract

The invention relates to the measurement for the lipid molecule content in a human blood sample as well as the preparation and the application of a colon cancer or rectum cancer diagnosis reagent kit, in particular to the extraction of lipid molecules in a human blood sample and the content measurement thereof as well as the definition of colon cancer or rectum cancer lipid molecule marks. In addition, the invention also discloses the details about the detection of a few colon cancer or rectum cancer lipid molecule marks in a blood sample and provides a reagent kit which is formed according to the lipid molecule marks and used for colon cancer or rectum cancer diagnosis. According to the content of the lipid molecule marks in the sample, the possibility for a patient suffering the colon cancer or rectum cancer can be diagnosed from the sample through special calculation and analysis, and the invention also provides a new means for the healing efficacy analysis in the colon cancer or rectum cancer treatment.

Description

technical field [0001] The present invention provides a method for determining the levels of various lipid molecules in a blood sample of an individual, including various subtypes of lysophosphatidylcholine (LPC) (14:0LPC, 16:0LPC, 18: 0LPC, 20:0LPC, 22:0LPC, 18:1LPC, 18:2LPC, 20:4LPC, 22:6LPC, using the Arabic numerals of unsaturated organic compounds for positioning, the number after the colon indicates the position of the double bond), sphingosine Phosphocholine (SPC), platelet activating factor (L-PAF), sphingomyelin (SM, including SM703 and SM731, where 703 and 731 refer to the molecular weight of the two subtypes, respectively). We have invented a biomarker combination of lipid molecules, prepared it into a kit, and used human blood as a sample to determine the possibility of an individual suffering from colorectal cancer based on the content determination and comprehensive analysis of lipid marker molecules. This is an auxiliary detection of colorectal cancer. Backgr...

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Application Information

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IPC IPC(8): G01N30/72G01N30/74G01N30/78
Inventor 桑建利徐燕张俊杰赵克肖刚叶颖江丛羽生张伟张研
Owner 桑建利
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