70 results about "Phthalazine" patented technology

The present invention provides a compound of Formula (I):

wherein the variables Z, n, Y and p are as defined herein, and pharmaceutically acceptable salts thereof, which can inhibit the activity of poly (ADP-ribose)polymerases, and pharmaceutical compositions comprising the same.

The invention discloses an iridium complex phosphor material taking a phthalazine derivative as a ligand. The structure of the material is shown as formulas (I) and (II), wherein Ar represents aryl, substituted aryl, heterocycle aryl and substituted heterocycle aryl; R can be one of a halogen atom, alkyl, substituted alkyl, alkoxyl, aryloxy, an alkylthio group, arylthio, aromatic amino, aliphatic amino or a heterocyclic substituent; L^Y can be one of N-COOH, 8-hydroxyquinoline, beta-diketone, N^NH and the like; N^N can be bipyridyl, diquinoline, 1,10-phenanthroline, a derivative of the 1,10-phenanthroline and the like; and Z can be hexafluorophosphate and perchlorate. A dicyclic or ionic iridium complex phosphorescent electroluminescent device taking the phthalazine derivative as the ligand obtained with the preparation method has high internal and external quantum yields, high luminance and high stability. A dicyclic iridium complex is shown as a formula (I), i.e., (C^N)2Ir(L^Y); and an ionic iridium complex is shown as a formula (II), i.e., (C^N)2Ir(N^N)<+>Z<->.

The invention discloses a novel block anion exchange membrane. A block main chain of the anion exchange membrane contains a bending unit (biphenyl fluorene) and a twisting unit (phthalazinone); according to the structure, a non-coplanar effect can be enhanced. A preparation method of the anion exchange membrane comprises the following steps of performing polycondensation on decafluorobiphenyl (slightly excessive) and bisphenol fluorine to prepare an oligomer 1; using the decafluorobiphenyl and 4-(4-hydroxyphenyl)-2,3-phthalazine-1-one to prepare an oligomer 2; polymerizing the oligomer 1 with the oligomer 2 to obtain a polymer main chain, and performing ionization treatment, membrane casting and alkali treatment on a chloromethylation main chain to obtain the anion exchange membrane. The anion exchange membrane has better chemical stability, and higher electric conductivity and resistance to swelling, and is suitable for being applied in the aspect of alkaline fuel cells.

The present invention discloses a red light organic electrophosphorescence material metal iridium coordination compound having a structural formula represented by a formula (P), wherein R is methyl. The present invention further provides an organic electroluminescent device containing the metal iridium coordination compound. According to the present invention, 1-methoxy-4-phenyl phthalazine is adopted as the ring metal ligand main structure, and acetylacetone is adopted as the heterotypic auxiliary ligand to synthesize the heterotypic coordination type metal iridium coordination compound having high red luminescence color purity so as to reduce the synthesis difficulty and the purification difficulty of the metal iridium coordination compound; and the chemical modification method that the two methyl groups are introduced on different C sites of the benzene ring in the ring metal ligand is adopted to achieve adjustment on the material luminescence color so as to make the metal iridium coordination compound phosphorescence emission spectrum produce red shift.

A refractory and soluble copolyarylamide is prepared from the moldifier which is the mixture of a novel diamine and the diamine H2N-Ar-X-Ar-NH2, and poly-p-phenyl diformyl p-pheyldiamine (PPTA) through directly condensation or low-temp solution polymerizing in the solution of the salt of alkali metal or alkali-earth metal. Its advantages are high vitrification temp and inherent viscosity, and better solubility, mechanical performance and thermal stability.

The invention discloses a method for efficient catalytic synthesis of 2H-indole [2,1-b] phthalazine-1,6,11(13H) triketone, and belongs to the technical field of ionic liquid catalysis. The molar ratio of aromatic aldehyde, phthalylhydrazine and 5,5-dimethyl-1,3-cyclohexanedione in synthesis reaction is 1 to 1 to 1; the molar quantity of an acidic ionic liquid catalyst is 3%-7% of used phthalylhydrazine; the volume dose of a reaction solvent based on milliliter is 3-5 times of the molar quantity of the phthalylhydrazine based on millimole; and the method comprises the following steps: carrying out reflux reaction for 8-30 minutes; ending reaction, cooling to a room temperature, and separating out a lot of solids; carrying out suction filtration, washing residues with ethanol, and drying in vacuum to obtain a product. Compared with a synthesis method employing other acidic ionic liquid catalysts, the method has the characteristics of being high in catalytic activity of the catalyst, good in biodegradability and relatively in low preparation cost; the overall synthesis process is simple and convenient to operate; and industrialized large-scale application is facilitated.

The invention provides a pyridazinone derivative, and a preparation method and a medical application thereof. O-formylbenzoic acid used as a raw material reacts with dimethyl phosphite to obtain dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate, the dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate reacts with 3-cyano-4-fluorobenzaldehyde in the presence of triethylamine to prepare (Z,E)-2-fluoro-5-[(3-oxoisobenzofuran-1(3H)-ylidene)methyl]benzonitrile, and the (Z,E)-2-fluoro-5-[(3-oxoisobenzofuran-1(3H)-ylidene)methyl]benzonitrile is reduced by hydrazine hydrate to prepare 2-fluoro-5-[(4-oxo-3,4-dihydropyridazin-1-yl)methyl]benzoic acid; and benzaldehyde or substituted aromatic formaldehyde or furfural used as a raw material and malonic acid undergo a Knoevenagel reaction to obtain cinnamic acid or substituted cinnamic acid or furan-2-acrylic acid, the cinnamic acid or substituted cinnamic acid or furan-2-acrylic acid and 1-tert-butoxycarbonylpiperazine undergo an amidation reaction, a tert-butoxycarbonyl group is removed from the obtained amidation product in the presence of trifluoroacetic acid, and the obtained product and the 2-fluoro-5-[(4-oxo-3,4-dihydropyridazin-1-yl)methyl]benzoic acid undergo the amidation reaction to obtain a series of (E)-4-{3-[4-[(3-substituted aryl)acryloyl]piperazin-1-carbonyl]-4-fluorobenzyl}-2H-pyridazin-1-one derivatives. Results of preliminary pharmacological activity screening show that the compound represented by a general formula shown in the present invention has a certain in-vitro PARP-1 inhibition ability and a certain in-vitro tumor cell proliferation resisting activity. The structural general formula of compound is shown in the description; and in the general formula, Ar is selected from two formulas also shown in the description, and R1, R2, R3, R3, R4 and R5 can be the hydrogen atom, the fluorine atom, the chlorine atom, the bromine atom, a methyl group, a methoxy group, a tetrafluoromethyl group and a nitro group.

The invention relates to iridium complexes, wherein 2-(5-phenyl-1,3,4-oxadiazole-2-)phenol or 2-(5-(3-pyridine)-yl-1,3,4-oxadiazole-2-)phenol is emplyoed as an auxiliary ligand; and a derivative of any one of 2-(4,6-ditrifluoromethylpyridine-3-)quinoline, 2-(4,6-ditrifluoromethylpyridine-4-)quinoline, 2-(4,6-ditrifluoromethylpyridine-3-)isoquinoline, 2-(4,6-ditrifluoromethylpyridine-4-)isoquinoline, 2-(4,6-ditrifluoromethylpyridine-3-)quinazoline, 2-(4,6-ditrifluoromethylpyridine-4-)quinazoline, 2-(4,6-ditrifluoromethylpyridine-3-)phthalazine and 2-(4,6-ditrifluoromethylpyridine-4-)phthalazine is employed as a main ligand. The luminous intensity and efficiency of the iridium complexes, within the wavelength range of red light, can be regulated.

The invention discloses a phthalizine [1,2,b] quinazoline-8-ketone compound, which is characterized in that the structural general formula of the compound is shown in the description, and phthalizine [1,2,b] quinazoline-8-ketone derivatives disclosed by the invention have very strong inhibiting effect on common cancer cells such as human gastric carcinoma cells (MGC-803), human lung cancer cells (NCI-H460), human hepatoma cells (HepG-2), cervical carcinoma cells (Hela), human bladder cancer cells (T-24) and the like, can induce apoptosis of the cancer cells, hence the phthalizine [1,2,b] quinazoline-8-ketone and derivatives thereof have potential application in preparation of antitumor drugs.

The invention discloses a phthalazinopyrrole compound and a preparation method thereof. The phthalazinopyrrole compound has potential antibacterial, anti-inflammatory and anti-tumour activities. The preparation method of the compound comprises the following steps: under the nitrogen protection condition, dissolving phthalazine derived 1,3-dipole and allene ester into an organic solvent, adding an organic phosphine catalyst, stirring, and carrying out cycloaddition reaction, so that the phthalazinopyrrole compound can be obtained.

The present invention discloses a red light organic electrophosphorescence material metal iridium coordination compound having a structural formula represented by a formula (P), wherein R is hydrogen atom or methyl. The present invention further provides a preparation method for the coordination compound, and an organic electroluminescent device containing the coordination compound. According to the present invention, 1-methoxy-4-phenyl phthalazine having large plane rigidity is adopted as the main ligand so as to balance charge transmission of the organic electroluminescent device, and acetylacetone is added to the ring metal ligand as the heterotypic auxiliary ligand so as to reduce the synthesis difficulty of the metal iridium coordination compound, and easily synthesize and purify the product.

The invention discloses a synthetic method of Taladegib. The synthetic method is characterized by comprising the following steps that reductive amination is carried out on N-benzyl-4-piperidone to obtain a compound in formula VI; in the presence of an organic base, an acylation reaction is carried out on the compound in the formula VI and an acylation reagent to obtain a compound in the formula VIII; the acylation reagent is 4-fluoro-2-(trifluoromethyl)benzoyl chloride; in the presence of a hydrogen source and a palladium catalyst, debenzylation is carried out on the compound in formula VIII to obtain a compound in the formula IX; in the presence of an inorganic base, the compound in the formula IX is reacted with 1,4-dichloro phthalazine to obtain a compound in the formula X; in the presence of the inorganic base and the palladium catalyst, an SUZUKI coupling reaction is carried out on the compound in the formula X and 1-methyl-1H-pyrazole-5-boronic acid pinacol ester to obtain Taladegib. According to the invention, the process route is improved, cheap N-benzyl-4-piperidone is taken as a starting material, the processes of Boc protection and deprotection are removed to reduce the synthesis steps and reduce the production cost.

The present invention provides a red light organic electrophosphorescence material metal iridium coordination compound, which adopts 1-methyl-4-phenyl phthalazine or a derivative as a ring metal main ligand, adopts acetylacetone as an auxiliary ligand, and has a structural formula represented by a formula (1), wherein R is hydrogen or methyl. The preparation method comprises that: a Suzuki coupling reaction is performed to prepare a ring metal main ligand, the ring metal main ligand and IrCl3.3H2O are subjected to polymerization in a 2-ethoxyethanol and water mixed solvent to obtain a chloro-bridge dimer, and the chloro-bridge dimer and acetylacetone are subjected to a ligand exchange reaction to obtain the red light organic electrophosphorescence material metal iridium coordination compound. According to the present invention, 1-methyl-4-phenyl phthalazine or a derivative thereof is adopted as the ring metal main ligand, acetylacetone is adopted as the auxiliary ligand, and the emission wavelength can be adjusted so as to obtain the red light near the standard red color; and the organic electroluminescent device prepared from the material can emit high purity red light, the luminescence efficiency is high, and the preparation method is simple and is suitable for industrial production.

The invention discloses a preparation method of ethyl benzoylacetate, and belongs to the technical field of chemical synthesis. The preparation method comprises the following steps of: adding sodium bicarbonate into carbon tetrachloride, slowly adding ethyl acetoacetate, dropwise adding benzoyl chloride for reaction, adding sodium hydroxide for reaction, and filtering after the reaction is finished to obtain ethyl benzoylacetate. A microporous filter membrane is used in the process of preparing ethyl benzoylacetate. A reinforcing filler is prepared in the process of preparing the microporous filter membrane, and nano silicon dioxide and aniline are treated by the reinforcing filler, so that polyaniline is grafted on the surface of the nano silicon dioxide. Then, the nano silicon dioxide and modified graphene are subjected to ultrasonic treatment to obtain a reinforced substrate. 4-(4-hydroxyphenyl)-2, 3-phthalazine-1-one and epichlorohydrin are subjected to a reaction to prepare epoxy resin, then the epoxy resin and amino groups on the reinforced substrate are cured to prepare a reinforcing filler, the reinforcing filler can enhance the corrosion resistance of the microporous filter membrane, and the microporous filter membrane cannot be corroded after being used for a long time.