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Application of compound 1-( 4-chloroaniline )-4-( 4-picoline )-2, 3-naphthyridine

A picoline-based and chloroaniline-based technology, applied in the field of compound 1--4--2, can solve the problem of tumor tissue killing

Active Publication Date: 2008-02-06
BIOLOGY INST OF SHANDONG ACAD OF SCI
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  • Abstract
  • Description
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Problems solved by technology

[0007] However, unfortunately, in fact, once the tumor has appeared, angiogenesis inhibitors can inhibit the formation of new blood vessels, but they cannot kill the already formed tumor blood vessels and tumor tissues that have grown up, so it is necessary to apply angiogenesis inhibitors in advance , it is more realistic to prevent the occurrence of tumor diseases

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  • Application of compound 1-( 4-chloroaniline )-4-( 4-picoline )-2, 3-naphthyridine
  • Application of compound 1-( 4-chloroaniline )-4-( 4-picoline )-2, 3-naphthyridine
  • Application of compound 1-( 4-chloroaniline )-4-( 4-picoline )-2, 3-naphthyridine

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Embodiment Construction

[0010] Technical scheme of the present invention is as follows:

[0011] Use of the compound 1-(4-chloroanilino)-4-(4-methylpyridyl)-2,3-naphthyridine of the following formula in the preparation of drugs for preventing the occurrence of tumor diseases.

[0012]

[0013] The term "prevention" in the present invention means that the occurrence and formation of tumors is at least delayed or avoided, and tumor patients treated with drugs containing the above compounds have a higher survival rate than those without prevention.

[0014] The term "neoplastic disease" in the present invention means a neoplastic proliferative disorder, such as a solid tumor disease. The term "solid tumor disease" as used herein refers especially to breast cancer, ovarian cancer, cervical cancer, colon cancer and usually gastrointestinal cancer, lung cancer, kidney cancer, bladder cancer, prostate cancer, skin cancer, head and neck cancer or brain tumors.

[0015] In the present invention, the term ...

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Abstract

The invention relates to the use of compound 1-(4-chlorobenzene amidocyanogen)-4-(4-methylpyridine)-2, 3-phthalazine in preparing medicine used for preventing tumor diseases, wherein the medicine contains 1-(4-chlorobenzene amidocyanogen)-4-(4-methylpyridine)-2, 3-phthalazine and is used through administration method via or outside intestines and stomach. The compound can at least prolong or avoid occurrence or formation of tumor; moreover, tumor patient adopting medicine containing the compound for prevention obtains higher survival rate as compared with the patient who does not adopt the prevention method.

Description

technical field [0001] The invention relates to the application of a compound 1-(4-chloroanilino)-4-(4-methylpyridyl)-2,3-naphthyridine. technical background [0002] Angiogenesis involves the de novo formation of blood vessels from endothelial cell precursors or hemangioblasts. The first vascular structures in the embryo are formed by angiogenesis. Angiogenesis involves the development of capillaries from existing blood vessels and is the primary mechanism by which organs such as the brain and kidney form blood vessels. Although restricted to embryonic development, angiogenesis can occur in adults, for example during pregnancy, the female cycle, or wound healing. [0003] The major regulator of angiogenesis and angiogenesis in embryonic development and in certain angiogenesis-dependent diseases is vascular endothelial growth factor (VEGF). VEGF represents a family of mitogen isoforms that arise from alternative RNA splicing and exist as homodimers. VEGF can bind tyrosin...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/501A61P35/00
Inventor 刘可春韩利文王加宁陈贯虹姜平王思锋于承建
Owner BIOLOGY INST OF SHANDONG ACAD OF SCI
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