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30 results about "Oncothermia" patented technology
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Oncothermia, i. e. the modulated deep electro-hyperthermia system is a fast-developing supportive, complementary treatment method against different types of tumors. The principles are based on the classical method of hyperthermia, but the aim, beside the absolute increase in temperature, is especially the direct electric-field energy absorption in the extracellular liquid and destroying the membrane of the cancer cells. Oncothermia's effect is synergic to radiotherapy and to numerous chemotherapies. Furthermore, it leads to an increased immunogenicity and effectively reduces the pain of the patient. Hyperthermia has been described as the "oldest identified weapon against cancer." It has been used since at least 1989. Oncothermia in general is not used as sole therapy. It is usually combined with chemotherapy, radiotherapy or other therapies and their combination. The method transfers energy using the principle of capacitive coupling of radio waves of 13,56-MHz. No external shielding is needed. Oncothermia utilizes the special absorption rate of the near-membrane extracellular liquid of the tumor.
Preparation method and application for multifunctional nanometer diagnosis and treatment agent integrating light emitting/CT/MR multi-mode imaging and tumor hyperthermia
InactiveCN103480006AGood dispersionGood biocompatibilityEnergy modified materialsX-ray constrast preparationsPolyethylene glycolSilicon dioxide
The invention relates to a preparation method and application for a multifunctional nanometer diagnosis and treatment agent integrating light emitting / CT / MR multi-mode imaging and tumor hyperthermia. The multifunctional nanometer diagnosis and treatment agent comprises up-conversion luminescence nano-particles, a silicon dioxide layer, near-infrared photothermal conversion agent particles and sulfhydryl functionalization polyethylene glycol, wherein the up-conversion luminescence nano-particles have the performance of near-infrared light emitting / CT / MR three-mode imaging; the surfaces of the up-conversion luminescence nano-particles are wrapped with the silicon dioxide layer; the near-infrared photothermal conversion agent particles are in electrostatic adsorption on the surface of the silicon dioxide layer; the sulfhydryl functionalization polyethylene glycol is grafted onto the surfaces of the near-infrared photothermal conversion agent particles. The multifunctional nanometer diagnosis and treatment agent provided by the invention can integrate light emitting / CT / MR multi-mode imaging and the tumor hyperthermia into a whole, and through the stimulation of a single wave band, the light emitting imaging and tumor hyperthermia can be achieved simultaneously.
Owner:SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
Multispectral optical technology fused temperature measuring device
PendingCN107677621AInaccurate resolutionLarge measuring rangeThermometers using physical/chemical changesDiagnostic recording/measuringBeam splitterLocal Hyperthermia
The invention discloses a multispectral optical technology fused temperature measuring device. The temperature measuring device comprises a multispectral tunable laser device, a variable color filter,a light beam shaping device, a light beam bidirectional beam splitter, a reference arm, a spectrograph, a collimation and beam expanding lens assembly, a pinhole diaphragm, a high-velocity scanning galvanometer, a large-aperture microobjective, a water channel, an ultrasonic detector, a high-precision temperature heating controller, a temperature sensor and a computing unit. According to the device, internal temperature distribution condition of tissues for tumor local thermotherapy can be measured comprehensively and quickly in real time, imaging and accurate measurement can be carried out simultaneously on changed feature information of internal fine morphological structures of the tissues in the heating process, and rapid multi-dimensional imaging is provided in the state that the internal structures and components inside the tissues are changed in tumor thermotherapy.
Owner:XIAMEN UNIV
Simulated measurement of heat field distribution in microwave solidification treatment of tumor
InactiveCN1453563AReal-time 3D thermal field distributionThermometers using electric/magnetic elementsUsing electrical meansAbnormal tissue growthHeat conducting
The simulated measurement of heat field distribution in microwave solidification treatment of tumor includes the following steps: making microwave radiation field simulating measurer; setting microwave antenna inside the simulating measurer and setting measuring thermocouples connected via data collector to computer in proper positions; setting microwave body mold inside the simulating measurer; measuring temperature varying with time with the thermocouples, substituting the data into biological heat conducting equation to obtain the microwave radiation energy SAR per unit volume and per unittime, substituting SAR into dispersion function equations, solving the simultaneous equations in computer to obtain the coefficients of the dispersion function equations and the 3D heat field dispersion function of microwave radiation as well as the temperature in certain points in certain time.
Owner:广东世荣兆业股份有限公司 +1
Gastric cancer lymph node staining pathological image automatic identification method and system based on deep neural network
InactiveCN111145176AImprove diagnostic efficiencySatisfactory clinical effectImage enhancementImage analysisStainingPathology diagnosis
The invention relates to a gastric cancer lymph node staining pathological image automatic recognition system based on a deep neural network, and the system comprises a first module which removes a background region of a slice image, and extracts a tissue region as a region of interest; a second module which is used for cutting the slice image into small imagesand inputting the small images into adeep neural network, wherein the deep neural network comprises a first unit, a second unit, a third unit, a fourth unit and a fifth unit, the first unit is used for calculating a tumor probability score of each small image; the second unit synthesizes a tumor thermodynamic diagram of the whole tissue slice image according to the tumor probability scores of the plurality of small images; the thirdunit binarizes the tumor thermodynamic diagram to generate a monochrome mask diagram, the fourth unit uses median filtering to remove false positive points, and the fifth unit is used for calculatingthe number of positive points in the whole mask graph. The system can automatically identify the slice image of the gastric cancer metastatic lymph node, and can improve the efficiency of the diagnosis process in histopathology.
Owner:QINGDAO UNIV
Magnetic nanoparticles with dual-heating function and preparation method thereof
InactiveCN103623406AWith dual heating functionGood dispersionEnergy modified materialsAntineoplastic agentsMagnetite NanoparticlesNanoparti cles
The invention provides magnetic nanoparticles with a dual-heating function and a preparation method thereof. The preparation method is characterized in that ferroferric oxide (Fe3O4) nanoparticles are prepared and serve as cores, and the magnetic induction of the ferroferric oxide nanoparticles is used for targeting tumor cells and carrying out the magnetic thermal therapy; and gold is used as shells of the magnetic nanoparticles, and the photosensitivity of the gold is used for carrying out near-infrared thermal therapy; and the constructed novel Fe3O4@Au compound magnetic nanoparticles can simultaneously serve as a magnetic induction agent and a photosensitizer for tumor thermotherapy. The compound magnetic nanoparticles prepared by the method are injected into an animal model for tumor and can be used for carrying out magnetic thermal therapy and photo-thermal therapy on a living animal model. The treatment effect of the magnetic nanoparticles on tumor is obviously superior to that of a single treatment method.
Owner:SOUTHEAST UNIV
Phantom model for simulating clinical tumor thermal ablation treatment
The invention discloses a phantom model for simulating clinical tumor thermal ablation treatment. The formula comprises the following components of acrylamide, methylene acrylamide, temperature-sensitive ink with 5% v / v, ammonium persulfate with 0.14% w / v, TEMED with 0.1% v / v, wherein the w / v of acrylamide and methylene acrylamide is 7%, the mass ratio of acrylamide to methylene acrylamide is 19:1, and the color of the temperature-sensitive ink can be changed from colorless to pink when the temperature of the temperature-sensitive ink is greater than or equal to 60 DEG C. The elasticity and texture of the phantom model are similar to those of liver tissue, the position of an ablation needle or a puncture needle in the phantom model can be clearly positioned and displayed in an ultrasonicimage, obvious color change occurs when the ablation temperature reaches 60 DEG C or above, and the phantom model can be used for evaluating the ablation range of thermal ablation. The phantom model has the advantages of strong plasticity, simple formula and convenient preparation, and can be used for simulating clinical tumor thermal ablation treatment.
Owner:TIANJIN CITY THIRD CENT HOSPITAL
Iron oxide-carbon nano tube-gemcitabine-lentinan compound material and preparation method thereof
InactiveCN110075297AReduce laser powerReduce concentrationOrganic active ingredientsEnergy modified materialsDispersityCarbon nanotube
The invention discloses an iron oxide-carbon nano tube-gemcitabine-lentinan compound material and a preparation method thereof. PEG-20000 is used as a dispersion agent for evenly dispersing iron oxideso that the iron oxide can be conveniently and evenly attached to carbon nano tubes on a nano scale, therefore, the magnetocaloric medium iron oxide and the optothermal medium carbon nano tubes are integrated. Prepared carbon nano tube-gemcitabine-lentinan carried with the iron oxide is applied in the field of biomedical, especially in tumor thermotherapy, on one hand, based on an optothermal effect, through a magnetic field, the iron oxide is induced to vibrate in a solution at a high speed for heating to generate a magnetocaloric effect, and in order to reach temperature required for tumorthermotherapy, laser power and a carbon nano tube concentration which are required for the optothermal effect of the carbon nano tubes in the compound material are reduced; and on the other hand, theiron oxide is guided by the magnetic field, and a carbon nano tube compound is driven by the iron oxide to move to a cancer-containing focus precisely, so that the dispersity of the carbon nano tube compound material which does not contain iron oxide is greatly reduced, and heat is conveniently concentrated for precise strikes.
Owner:XI AN JIAOTONG UNIV
Tumor thermal ablation device based on non-contact power supply
ActiveCN110890795AAccurate placementPrecise positioningOhmic-resistance heating circuitsCircuit arrangementsTransmitter coilEngineering
The invention discloses a tumor thermal ablation device based on non-contact power supply. The tumor thermal ablation device comprises an electromagnetic generation device, a transmitting coil, a receiving coil and an electric heating element; the output end of the electromagnetic generation device is connected with the transmitting coil, and the electromagnetic generation device is used for generating electromagnetic energy and transmitting the electromagnetic energy to the transmitting coil; the receiving coil and the transmitting coil are correspondingly arranged, and the receiving coil isused for receiving electromagnetic energy transmitted by the transmitting coil and converting the electromagnetic energy into electric energy; the output end of the receiving coil is connected with the electric heating element; when tumor thermal ablation treatment is carried out, the electric heating element is arranged in a to-be-treated tumor area. According to the tumor thermal ablation devicebased on non-contact power supply, the non-contact power supply technology is adopted, electric energy is directly led into a tumor tissue part, and thermal ablation of tumor tissue is achieved through temperature control heating of the electric heating element; accurate positioning can be achieved within the minimally invasive scale, the conformability is good, a thermal field is evenly distributed and can be regulated and controlled, wounds to the human body are small, and damage to normal tissue is small.
Owner:宴晶科技(北京)有限公司
Biological tissue temperature field passive regulation and control method based on optical phase change nanoparticles
The invention discloses a biological tissue temperature field passive regulation and control method based on optical phase change nanoparticles, relates to the technical field of tumor photothermal therapy, and aims to solve the problem of how to reduce the damage range of normal biological tissues while ensuring the effectiveness of thermal therapy in tumor photothermal therapy. The method comprises the following steps: calculating the change condition of absorption factors Qabs of nanoparticles meeting the requirements along with the laser wavelength before and after phase change, and further selecting the nanoparticles meeting the requirements; calculating the change condition of the absorption factor along with the laser wavelength before and after phase change after the surfaces of the nanoparticles are coated, and selecting the nanoparticles meeting the requirements again; and calculating the quality factor P of the nanoparticles, and selecting the nanoparticle with the maximum quality factor as a phase change material required by laser-induced tumor thermal therapy. According to the invention, a biological tissue temperature field passive regulation and control technology based on optical phase change nanoparticles can be obtained.
Owner:HARBIN INST OF TECH
188Re-labelled folic acid coupled cis-platinum magnetic albumin compound nano-particle as well as preparation method and application thereof
InactiveCN101850128AStrong anti-tumor pharmacological effectHigh purityRadioactive preparation carriersRadioactive preparation formsProtein moleculesMicrosphere
The invention relates to the technical fields of nuclear medicine, oncology and pharmaceutical pharmacy and provides a 188Re-labelled folic acid coupled cis-platinum magnetic albumin compound nano-particle as well as a preparation method and application thereof, wherein the 188Re-labelled folic acid coupled cis-platinum magnetic albumin compound nano-particle has the structure that folic acid active ester is coupled with an amino group on the surface of an albumin nano-particle, 188Re is connected with a hydrosulfide group of cysteine in a protein molecule, and cis-platinum and magnetic particles are packaged in the albumin nano-particle. The invention is mainly applied to the therapy, the diagnosis and the prevention of ovarian cancer tumor and has the advantages that an albumin nano-microsphere is used as a carrier, a folic acid receptor is used as an effect target, and chemotherapy, thermotherapy and nuclide radiotherapy are organically combined together, thereby not only solving the problems of automatic temperature control and constant temperature in tumor thermotherapy, but also solving the problem of directional lethal effect of the chemotherapy and nuclear radiation and satisfying the requirements for three aspects of safety, validity and specificity as far as possible.
Owner:陈道桢 +1
Simulated measurement of heat field distribution in microwave solidification treatment of liver tumor
InactiveCN1257393CReal-time 3D thermal field distributionThermometers using electric/magnetic elementsSurgical instrument detailsPig liverDimensional simulation
The method for simulating the heat field distribution of the microwave coagulation treatment of liver tumors in the invention is a simulation measurement method of the heat field distribution during the microwave coagulation treatment of liver tumors. Including 1), the pre-experiment on the isolated pig liver, it is found that the single embedded microwave wireless is symmetrically distributed in the r direction and the θ direction: 2) making a two-dimensional simulation measurement device for the microwave radiation field, 3) placing the microwave antenna Put it into the two-dimensional analog measurement device, and set the measurement thermocouple at the corresponding position. The thermocouple is connected to the data collector, and the latter is connected to the computer. 4), the tissue microwave phantom is blanked in the two-dimensional analog measurement device, ), measuring the temperature change with time at the position where the thermocouple is set for microwave radiation of different energies, and substituting the data into the biological heat transfer equation to obtain the microwave radiation energy SAR per unit volume and unit time, and substituting the SAR into its distribution function equation , by solving this simultaneous equation with a computer, the coefficients of the distribution function equation can be obtained, and the distribution function of the three-dimensional thermal field of microwave radiation can be obtained, so that the temperature at a specified point at a specified time can be obtained.
Owner:广东世荣兆业股份有限公司 +1
Multi-frequency tumor thermal ablation equipment and instrument and control method and device
PendingCN111643182AImprove work efficiencyReduce operational complexitySurgical needlesSurgical instruments for heatingOncothermiaExAblate
The invention provides multi-frequency tumor thermal ablation equipment and instrument and a control method and device. By use of the ablation instrument, a current identification signal of a currenttreatment needle is obtained from a connected intelligent identification module after any current treatment needle in at least two treatment needles is connected to the ablation instrument and the intelligent identification module corresponding to the current treatment needle is also connected to the ablation instrument, wherein different identification signals correspond to different types of treatment needles; current working mode information corresponding to the current treatment needle is determined according to the current identification signal, wherein different current working mode information corresponds to different types of treatment needles; and after the thermal ablation work is started, when a power source needs to be output to the current treatment needle, the output of the power source is controlled according to the current working mode information. The operation complexity of ablation treatment by related personnel can be reduced, and the accuracy of needle temperaturecontrol can be enhanced in an optional scheme.
Owner:上海倍可达医疗科技有限公司
Preoperative ablation area simulation method and device for tumor thermal ablation
A preoperative ablation area simulation method and device for tumor thermal ablation, the method includes: (1) selecting data suitable for training, the doctor marks the preoperative and postoperative images, and obtains the preoperative liver, postoperative ablation area and needle path; (2) Register the postoperative image to the preoperative image, and add rigid restrictions during the registration process so that the ablation area and the needle track area do not undergo elastic deformation, and use the deformation field obtained by registration to project the needle track information and the ablation area (3) Generate the ideal thermal field distribution map according to the projected needle track direction and position information and the corresponding power time used in the operation; (4) Establish a convolutional neural network to convert the ideal thermal field distribution map The preoperative image is cropped according to the preoperative liver mask, and the cropping results are combined as network input, and the deformed ablation area is used as the gold standard for learning to obtain a regression model, and the prediction of the ablation area is realized in the test phase.
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY
Electric heating scalpel for tumor thermotherapy and preparation method of electric heating scalpel
PendingCN111227925AAccurate control of heating temperatureSmall structureSurgical instruments for heatingCeramic compositeOncothermia
The present invention provides an electric heating scalpel for tumor thermotherapy. The electric heating scalpel for the tumor thermotherapy comprises a scalpel head part, a scalpel body part and a handle part which are connected together, the scalpel body part is positioned between the scalpel head part and the handle part, the scalpel head part comprises a scalpel head and a connecting column, and the scalpel head and the connecting column are integrally arranged; the scalpel body part comprises a metal tube, a metal ceramic composite heating core is arranged in the metal tube, and the metalceramic composite heating core is connected with the scalpel head; the handle part comprises a metal connecting sleeve, the metal tube is arranged at the metal connecting sleeve, the metal connectingsleeve is sleeved with a handle sleeve, and one end, far away from the scalpel body, of the metal connecting sleeve is provided with a plug; and the plug is connected with the metal ceramic compositeheating core. The electric heating scalpel achieves accurate control of heating temperatures through the metal ceramic composite heating core and can achieve a good treatment effect.
Owner:惠州市兴鸿昌电器有限公司
Intraoperative dynamic path optimization method and device for tumor thermal ablation
PendingCN114451990ARelieve painReal-time optimization of puncture path during operationComputer-aided planning/modellingRespiratory gatingDecision model
According to the intraoperative dynamic path optimization method and device for tumor thermal ablation, unnecessary pain brought by respiratory gating to a patient can be reduced, the complexity of a constructed model is moderate, the situation that a 4D model is too complex and consumes too much time and resources is avoided, and the problems that the constructed respiratory movement model is poor in precision and low in reliability are solved. The problems that a puncture path in an operation cannot be optimized in real time, the operation is completed in combination with liver movement under an overall optimal result, a needle inserting path is quantified, display is visual, and operation is simple and easy to implement are solved. The method comprises the following steps: (1) obtaining a segmentation result from a preoperative CT image; obtaining a liver puncturable area, and constructing a preoperative optimal needle insertion path; constructing a breathing model, matching liver motion with breathing phase, and dispersing a breathing signal into k phase segments; for each phase segment, constructing a Markov decision model on the preoperative CT image; accurately assigning a value to the state transition probability Psa; and obtaining an optimal strategy graph of liver puncture.
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY
A kind of metal sulfide nanomaterial and its preparation method and application
ActiveCN107961375BGreat penetration depthReduce absorptionEnergy modified materialsInorganic active ingredientsNitrosoBismuth sulfide
The invention discloses a metal sulfide nanomaterial, a preparation method and application thereof. The metal sulfide nanomaterial includes bismuth sulfide nanorods and a high polymer material and a nitric oxide donor that coat the bismuth sulfide nanorods. The high polymer material is polyoxyethylene sorbitan laurate Tween-20, and the nitric oxide donor includes BNN (bis-N-nitroso compound). Themetal sulfide nanomaterial can convert light energy into heat, and utilizes the photothermal conversion process to promote the nitric oxide donor to decompose and release nitric oxide, also controlledrelease of nitric oxide and photothermal therapy can realized simultaneously, nitric oxide can reduce the self-protection effect of tumor cells during thermal therapy and significantly improve the tumor treatment effect. Therefore, the metal sulfide nanomaterial provided by the invention overcomes the disadvantages of the traditional tumor thermotherapy method, and is suitable for tumor treatmentwith complex needs.
Owner:INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
Thermal therapy coil handle and equipment
The invention relates to a thermotherapy coil handle and equipment, and belongs to the technical field of thermotherapy, the thermotherapy coil handle comprises a handle body, a coil and a connecting wire, the coil is arranged at one end of the handle body; one end of the connecting line is connected with the coil, and the other end of the connecting line is connected with an equipment host. The coil has the effect of solving the problem that a doctor cannot hold and operate the coil conveniently in the thermal therapy process when different tumors of multiple viscera are subjected to thermal therapy.
Owner:北京大学(天津滨海)新一代信息技术研究院
Tumor-bearing tissue model for US/CT-guided downlink tumor puncture or thermal ablation training and preparation method thereof
The invention discloses a tumor-bearing tissue model for US / CT-guided downlink tumor puncture or thermal ablation training. The tumor-bearing tissue model comprises a normal tissue phantom and a tumor phantom embedded in the normal tissue phantom, the normal tissue phantom contains acrylamide gel, temperature-sensitive ink and sodium chloride; the tumor phantom contains acrylamide gel, temperature-sensitive ink, sodium chloride, a US contrast agent and a CT contrast agent; and the acrylamide gel is a gel formed by carrying out a polymerization cross-linking reaction on acrylamide and methylene bisacryl amide. According to the tumor-bearing tissue model, the position and size of a tumor can be accurately positioned and evaluated, and tumor puncture and thermal ablation training under the guidance of US / CT can be carried out; and the range of the coagulative necrosis area after thermal ablation can be simply and visually displayed in a color change mode, so that the tumor thermal ablation effect can be accurately evaluated. The invention also discloses a preparation method of the tumor-bearing tissue model, which is simple to operate, low in cost, efficient in reaction, easy in process control, green and environment-friendly.
Owner:THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV +1
A method for passive regulation of biological tissue temperature field based on optical phase change nanoparticles
The invention relates to a method for passively regulating the temperature field of biological tissues based on optical phase-change nanoparticles, which relates to the technical field of tumor photothermal therapy. The purpose of the present invention is to solve the problem of how to reduce the damaged range of normal biological tissues while ensuring the effectiveness of thermal therapy in tumor photothermal therapy. Method: Calculate the absorption factor Q of qualified nanoparticles before and after phase transition abs With the change of the laser wavelength, further select the nanoparticles that meet the requirements; calculate the change of the absorption factor of the nanoparticle surface coating before and after the phase transition with the laser wavelength, and select the nanoparticles that meet the requirements again; calculate the quality factor P of the nanoparticles , select the nanoparticle with the largest quality factor as the phase change material required for laser-induced tumor hyperthermia. The invention can obtain a passive regulation technology of the biological tissue temperature field based on the optical phase change nanoparticles.
Owner:HARBIN INST OF TECH
Blood tumor thermal therapy device
InactiveCN111728763ASpeed up the flowEasy to operateTherapeutic coolingTherapeutic heatingMedicineOncothermia
The invention belongs to the technical field of medical instruments, and particularly relates to a blood tumor thermal therapy device. The blood tumor thermal therapy device comprises a bottom plate,a telescopic plate, a base, a telescopic rod, a supporting frame, a bed plate, a transverse rod, a connecting ring and a connecting piece, wherein the bottom of bottom plate is connected with base; the left side and the right side of bottom plate are connected with the telescopic plate, and telescopic rod is installed at top of base; the bottom of the supporting frame is connected with the telescopic rod; the top of the supporting frame is connected with the bed plate; the supporting rod is installed at the top of the telescopic plate; the connecting ring is installed on the outer wall of thesupporting rod; the connecting piece is installed on the connecting ring; and the cross rod is connected with the connecting piece. According to the blood tumor thermal therapy device, the transverserod installed outside the thermal therapy device and a sliding groove formed in the outer portion of the thermal therapy device are fixed through a rotating heat isolation pad and other equipment, sealing operation is carried out on the periphery of the bed plate, and then thermal therapy is carried out, so that the influence on the external environment can be effectively reduced, meanwhile, the use range of the thermal therapy device is widened, and operation is convenient.
Owner:刘封
Tumor thermochemotherapy device
PendingCN113288402AAccurate temperature measurementAccurate and stable temperature dataSurgical instruments for heatingMedicineOncothermia
The invention relates to the technical field of medical instruments, in particular to a tumor thermochemotherapy device. The tumor thermochemotherapy device comprises a medicine storage tube, a heater, a temperature sensor and an injector, in actual use, liquid in the medicine storage tube flows in from the first connecting end, passes through the accommodating space and then flows out from the second connecting end, the accommodating space is filled with the liquid, and the other end of the temperature measuring part extends into the accommodating space, so that the temperature measuring part is in contact with the liquid in the accommodating space, and accurate temperature measurement is further performed; specifically, in the temperature measurement process of the temperature sensor, the temperature measurement part works in a closed working space (namely, an accommodating space), so that accurate and stable temperature data can be measured and provided, and the influence of the environment temperature on temperature measurement is effectively reduced; therefore, the technical problem that the treatment effect is affected due to the fact that the temperature measurement precision of a temperature sensor of an existing local thermochemotherapy device is not high is solved.
Owner:上海竑鹏肿瘤新技术中心
Magnesium-zinc ferrite for tumor hyperthermia and preparation method thereof
ActiveCN108585056BImprove magnetic propertiesEasy to prepareEnergy modified materialsInorganic material magnetismOncothermiaPhysical chemistry
The invention discloses a magnesium-zinc ferrite for tumor hyperthermia and a preparation method thereof, and belongs to the crossing field of material science and biomedicine. The magnesium-zinc ferrite Mg(1-x)ZnxFe2O4 (x is not less than 0.1 and not greater than 0.9) has a particle diameter of 20-100 nm; molar percentages of Mg<2+> and Zn<2+> in the magnesium-zinc ferrite are 90-10 mol% and 10-90 mol%, respectively. The preparation method provided by the invention is simple and does not require expensive equipment; in addition, the prepared magnesium-zinc ferrite has good magnetic propertiesand magnetocaloric properties, can be heated within a range of 43-50 DEG C or heated to 60 DEG C or higher rapidly under induction of an external magnetic field with a frequency of 215 kHz, and is predictably applied to the tumor hyperthermia, so that the magnesium-zinc ferrite provided by the invention has excellent industrial application prospects and practical application values.
Owner:SHANDONG UNIV
Three-dimensional tumor thermal ablation instrument and control method thereof
PendingCN113456210AAchieving Conformal Heat TherapySignificant ablationDiagnostic recording/measuringSurgical instruments for heatingExAblateOncothermia
The invention discloses a three-dimensional tumor thermal ablation instrument and a control method thereof. The three-dimensional tumor thermal ablation instrument is mainly used for heating a tumor through a heating device, monitoring the temperature change of normal tissues around the tumor through a temperature measuring needle, controlling the heating temperature through a control instrument, monitoring the temperature value of the normal tissues at the same time, inactivating the tumor without damaging the normal tissues, and treating the tumor.
Owner:韩俊霞
A tumor thermal ablation device based on non-contact power supply
ActiveCN110890795BAccurate placementPrecise positioningOhmic-resistance heating circuitsCircuit arrangementsTransmitter coilMedicine
Owner:宴晶科技(北京)有限公司
A tumor hyperthermia device based on an implanted coil and its parameter optimization method
ActiveCN109363826BTo achieve the effect of sustainable hyperthermiaAvoid harmElectrotherapyMagnetotherapyWireless transmissionOncothermia
The invention discloses a tumor thermotherapy device based on an implanted coil and a parameter optimization method thereof. In traditional tumor magnetic-mediated thermotherapy, it is necessary to inject heat-producing magnetic particles into the human body; and as the particles diffuse, the effect of hyperthermia decreases. The invention relates to a magnetically mediated hyperthermia device for tumors based on implanted coils, which includes internal coils and external coils. The extracorporeal coil is an open-loop single-turn circular coil. The internal body coil is a closed-loop single-turn circular coil. The radii of the external coil and the internal coil are r 1 and r 2 , the line radius is r w1 and r w2 . Among them, d is the wireless transmission distance. The invention can achieve the effect of sustainable hyperthermia on tumors.
Owner:温州慧电科技有限公司
APD hybrid nano system as well as construction method and application thereof
ActiveCN110917121ALow costPrevent coagulationOrganic active ingredientsEnergy modified materialsHyperthermia TreatmentChemo therapy
The invention discloses an APD hybrid nano system as well as a construction method and application thereof. The hybrid system is obtained by mixing nano-gold rods modified by a cationic polymer containing a mercapto group and a levorotary DNA tetrahedron and performing incubation. The method uses the unmodified DNA, avoids the use of expensive thiolated DNA, and is more conducive to reducing the costs of nano-scale drug carriers. Inventors find that experiments prove that the levorotary DNA can be resistant to ribozyme degradation, at the same time, after the polymer is compounded with the DNA, the DNA can be protected, and the stability of the system can be improved through dual effects; and the APD hybrid nano system has the ability to efficiently enter cells, can be used for loading drugs, especially chemotherapy drugs, and has application prospects in the field of tumor hyperthermia and chemotherapy combined therapy.
Owner:SICHUAN UNIV
A kind of APD hybrid nano system and its construction method and application
ActiveCN110917121BLow costImprove stabilityOrganic active ingredientsEnergy modified materialsHyperthermia TreatmentChemo therapy
The invention discloses an APD hybrid nano system and its construction method and application. The hybrid system is obtained by mixing and incubating nano-gold rods modified with thiol-containing cationic polymers and left-handed DNA tetrahedrons. The invention uses unmodified DNA, avoids the use of expensive thiol DNA, and is more conducive to reducing the cost of nanoscale drug carriers. The inventors have discovered and proved through experiments that the use of left-handed DNA can resist ribozyme degradation, and at the same time, after the polymer and DNA are compounded, the DNA can be protected, and the dual functions improve the stability of the system. The APD hybrid nanosystem also has the ability to enter cells efficiently. It can be used to load drugs, especially chemotherapy drugs, and has application prospects in the field of combined therapy of tumor hyperthermia and chemotherapy.
Owner:SICHUAN UNIV
Magnesium-zinc ferrite for tumor hyperthermia and preparation method thereof
ActiveCN108585056AImprove magnetic propertiesGood magnetocaloric performanceEnergy modified materialsInorganic material magnetismMaterials scienceHyperthermia
The invention discloses a magnesium-zinc ferrite for tumor hyperthermia and a preparation method thereof, and belongs to the crossing field of material science and biomedicine. The magnesium-zinc ferrite Mg(1-x)ZnxFe2O4 (x is not less than 0.1 and not greater than 0.9) has a particle diameter of 20-100 nm; molar percentages of Mg<2+> and Zn<2+> in the magnesium-zinc ferrite are 90-10 mol% and 10-90 mol%, respectively. The preparation method provided by the invention is simple and does not require expensive equipment; in addition, the prepared magnesium-zinc ferrite has good magnetic propertiesand magnetocaloric properties, can be heated within a range of 43-50 DEG C or heated to 60 DEG C or higher rapidly under induction of an external magnetic field with a frequency of 215 kHz, and is predictably applied to the tumor hyperthermia, so that the magnesium-zinc ferrite provided by the invention has excellent industrial application prospects and practical application values.
Owner:SHANDONG UNIV
Access door or gantry including antenna assembly for therapy or imaging
ActiveCN106535758BReduce lossesReduce mechanical stressElectrotherapyMicrowave therapyTherapeutic DevicesOncothermia
The invention relates to an access door or a stand and an antenna assembly for a therapy device or for an imaging device, in particular for a tumor thermotherapy system. In particular, said assembly comprises an access door or platform (2); an array of first antennas (3) connected to said platform (2); a bed (4), said bed being at least movable relative to said platform a frame (2) that moves longitudinally; and at least one second antenna (4A) disposed within said bed, wherein said assembly includes a lifting device (2A) for lifting said access door or platform.
Owner:皮耶尔弗朗切斯科帕沃尼
Application of heat-sensitive materials in the preparation of injections for protecting the surrounding structures of organs during thermal ablation
ActiveCN106902394BEnough protection thicknessThermal ablation safetySurgeryPharmaceutical delivery mechanismIntraperitoneal routePerfusion
The invention provides application of a thermosensitive material in preparation of an injection for protecting an organ peripheral structure in thermal ablation. The thermosensitive material is used for protecting an organ peripheral structure when a mammal abdominal solid organ is adjacently subjected to thermal ablation by a membrane tumor. The injection material is in a liquid state with good fluidity at a temperature of 0-4 DEG C or 10-22 DEG C, and is converted from liquid phase to solid phase or semi-solid phase without fluidity when the temperature is increased to 34-37 DEG C, so as to be able to stay in the injection position; and optimally, the injection material is converted into solid phase or semi-solid phase without fluidity within 10 seconds to 3 minutes. The injection prepared from the thermosensitive material is used for intraperitoneal injection instead of a conventional injection, so that an organ is separated from the peripheral structure which is easily injured by heat, an enough protecting thickness can be achieved, the thermal ablation can be safe, and the defects of large fluidity, short staying in a target region, durable perfusion requirement and the like of a conventional liquid.
Owner:BEIJING CANCER HOSPITAL PEKING UNIV CANCER HOSPITAL
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