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Iron oxide-carbon nano tube-gemcitabine-lentinan compound material and preparation method thereof

A technology of iron oxide compounds and carbon nanotubes, applied in wave energy or particle radiation treatment materials, drug combinations, pharmaceutical formulations, etc., can solve the problem of carbon nanotube strengthening, large dispersion of cancer-containing lesions, and inability to concentrate heat to kill tumors Cells and other issues to achieve the effect of facilitating precise strikes and reducing dispersion

Inactive Publication Date: 2019-08-02
XI AN JIAOTONG UNIV
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  • Abstract
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Problems solved by technology

Due to the large dispersion of cancer-containing lesions delivered by carbon nanotubes to tissues, it is impossible to concentrate heat to kill tumor cells
In addition, in order to reach a temperature sufficient to kill tumor cells, carbon nanotubes often require high-concentration carbon nanotubes and high-power lasers. Power density at 0.75W / cm 2
The above defects greatly limit the application of carbon nanotube materials in the treatment of cancer

Method used

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  • Iron oxide-carbon nano tube-gemcitabine-lentinan compound material and preparation method thereof
  • Iron oxide-carbon nano tube-gemcitabine-lentinan compound material and preparation method thereof
  • Iron oxide-carbon nano tube-gemcitabine-lentinan compound material and preparation method thereof

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preparation example Construction

[0040] A preparation method of iron oxide-carbon nanotube-gemcitabine-lentinan composite material The raw material components and main preparation steps are as follows:

[0041] The mass ratio of the main raw materials ferrous sulfate heptahydrate, carboxylated multi-walled carbon nanotubes, hydrogen peroxide (30% w / w), gemcitabine and lentinan is 28.594:4.571:5.829:3.286:1.

[0042] Iron oxide nanoparticles were prepared by chemical co-precipitation method, and magnetic particles were loaded onto carbon nanotubes through the dispersion of PEG and oil bath; gemcitabine was bonded with amide bonds and lentinan was attached to finally obtain carbon nanotubes loaded with iron oxide compounds. Nanotube-gemcitabine-lentinan composites. The composite material has good thermal effect under the action of 808nm laser irradiation and alternating magnetic field.

Embodiment 1

[0044] Take raw materials ferrous sulfate heptahydrate, carboxylated multi-walled carbon nanotubes, polyethylene glycol, ammonia water, hydrogen peroxide, absolute ethanol, phosphate buffer, N-hydroxysuccinimide, 1-ethyl-(3- Dimethylaminopropyl) carbodiimide, gemcitabine, lentinan and water; wherein, polyethylene glycol (PEG for short) is a mixture of homopolymeric monomers, with an average molecular weight of 20000g / mol; multi-walled carbon nanotubes are Mixture; the masses of ferrous sulfate heptahydrate, carboxylated multi-walled carbon nanotubes, hydrogen peroxide (30% w / w), gemcitabine, and lentinan were 2.502g, 0.4g, 0.51g, 0.2875g, and 0.0875g, respectively.

[0045] Step 1. Carrying magnetic nanoparticles

[0046] Step 1.1. Weigh 2.502g FeSO4·7H2O solid, add deionized in the test tube and use a mixer to fully dissolve FeSO4·7H2O; measure 0.4g carboxylated carbon nanotubes, and ultrasonically disperse them in the test tube; take 1.000g PEG-20000, Add water to 20ml unti...

Embodiment 2

[0067] Embodiment 2: A preparation method of a carbon nanotube magnetic composite material loaded with magnetic nanoparticles and anticancer drugs, the raw material components and main preparation steps are as follows:

[0068] Iron oxide nanoparticles were prepared by chemical co-precipitation method, and magnetic particles were loaded onto carbon nanotubes through the dispersion of PEG and oil bath; gemcitabine was bonded with amide bonds and lentinan was attached to finally obtain carbon nanotubes loaded with iron oxide compounds. Nanotube-gemcitabine-lentinan composites. The composite material has good thermal effect under the action of 808nm laser irradiation and alternating magnetic field.

[0069] The difference between this embodiment and embodiment 1 is:

[0070] 1) The mass ratio of the main raw materials ferrous sulfate heptahydrate, carboxylated multi-walled carbon nanotubes, hydrogen peroxide (30% w / w), gemcitabine, and lentinan is: 27.452:4.251:5.567:3.049:1.

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Abstract

The invention discloses an iron oxide-carbon nano tube-gemcitabine-lentinan compound material and a preparation method thereof. PEG-20000 is used as a dispersion agent for evenly dispersing iron oxideso that the iron oxide can be conveniently and evenly attached to carbon nano tubes on a nano scale, therefore, the magnetocaloric medium iron oxide and the optothermal medium carbon nano tubes are integrated. Prepared carbon nano tube-gemcitabine-lentinan carried with the iron oxide is applied in the field of biomedical, especially in tumor thermotherapy, on one hand, based on an optothermal effect, through a magnetic field, the iron oxide is induced to vibrate in a solution at a high speed for heating to generate a magnetocaloric effect, and in order to reach temperature required for tumorthermotherapy, laser power and a carbon nano tube concentration which are required for the optothermal effect of the carbon nano tubes in the compound material are reduced; and on the other hand, theiron oxide is guided by the magnetic field, and a carbon nano tube compound is driven by the iron oxide to move to a cancer-containing focus precisely, so that the dispersity of the carbon nano tube compound material which does not contain iron oxide is greatly reduced, and heat is conveniently concentrated for precise strikes.

Description

technical field [0001] The invention belongs to the technical field of iron oxide carbon nanotube preparation, and in particular relates to an iron oxide-carbon nanotube-gemcitabine-lentinan composite material and a preparation method thereof. Background technique [0002] Carbon nanotube materials have attracted widespread attention due to their excellent photothermal effects, especially in the medical field for the treatment of cancer cells. Because the carbon nanotubes are transported to the tissues, the cancer-containing lesions are highly dispersed, and it is impossible to concentrate heat to kill tumor cells. In addition, in order to reach a temperature sufficient to kill tumor cells, carbon nanotubes often require high-concentration carbon nanotubes and high-power lasers. Power density at 0.75W / cm 2 . The above defects greatly limit the application of carbon nanotube materials in the treatment of cancer. Contents of the invention [0003] In order to solve the a...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K31/7068A61K31/715A61K36/07A61K47/02A61K47/52A61P35/00
CPCA61K31/7068A61K31/715A61K36/07A61K41/00A61K41/0052A61K47/02A61K47/52A61P35/00A61K2300/00
Inventor 杨登天易文辉闫岸之张志扬刘佳明姜天舒张若彤陈博奇邓文雅易韬金伟秋杨其晟
Owner XI AN JIAOTONG UNIV
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