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Biological tissue temperature field passive regulation and control method based on optical phase change nanoparticles

A nanoparticle, biological tissue technology, applied in the field of tumor photothermal therapy

Active Publication Date: 2020-10-30
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to solve the problem of how to reduce the damage range of normal biological tissues while ensuring the effectiveness of thermal therapy in tumor photothermal therapy, and to provide a method for passively regulating the temperature field of biological tissues based on optical phase change nanoparticles

Method used

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  • Biological tissue temperature field passive regulation and control method based on optical phase change nanoparticles
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  • Biological tissue temperature field passive regulation and control method based on optical phase change nanoparticles

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specific Embodiment approach 1

[0017] Specific Embodiment 1: In this embodiment, a method for passively regulating the temperature field of biological tissues based on optical phase-change nanoparticles is completed according to the following steps:

[0018] 1. Select nanoparticles of different sizes, shapes and types whose crystallization temperature is between 40°C and 100°C and whose dielectric constant changes before and after the phase transition as the nanoparticles that meet the requirements;

[0019] 2. Draw the absorption factor Q of the qualified nanoparticles before and after the phase transition in step 1 abs The graph of the change with the laser wavelength, if there is a band where the absorption factor of the nanoparticle after the phase transition is lower than that of the nanoparticle before the phase transition, then the nanoparticle is a qualified nanoparticle;

[0020] 3. Draw a graph of the absorption factor of the nanoparticle surface coating that meets the requirements in step 2 befor...

specific Embodiment approach 2

[0025] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the different sizes mentioned in step 1 are equivalent radius of 20-100 nm.

[0026] Other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0027] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the different shapes described in Step 1 are nanospheres, nanorods, nanotriangular sheets or nanocages.

[0028] Other steps are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses a biological tissue temperature field passive regulation and control method based on optical phase change nanoparticles, relates to the technical field of tumor photothermal therapy, and aims to solve the problem of how to reduce the damage range of normal biological tissues while ensuring the effectiveness of thermal therapy in tumor photothermal therapy. The method comprises the following steps: calculating the change condition of absorption factors Qabs of nanoparticles meeting the requirements along with the laser wavelength before and after phase change, and further selecting the nanoparticles meeting the requirements; calculating the change condition of the absorption factor along with the laser wavelength before and after phase change after the surfaces of the nanoparticles are coated, and selecting the nanoparticles meeting the requirements again; and calculating the quality factor P of the nanoparticles, and selecting the nanoparticle with the maximum quality factor as a phase change material required by laser-induced tumor thermal therapy. According to the invention, a biological tissue temperature field passive regulation and control technology based on optical phase change nanoparticles can be obtained.

Description

technical field [0001] The invention relates to the technical field of tumor photothermal therapy, in particular to a method for passively regulating the temperature field of biological tissues based on optical phase transition nanoparticles. Background technique [0002] Traditional cancer therapy includes surgery, radiotherapy and chemotherapy. Surgical resection is usually difficult to remove all tumors. At the same time, some patients cannot undergo surgery due to various reasons. Chemotherapy and radiotherapy have serious side effects. Therefore, in recent years, tumor hyperthermia technology has received more and more attention as a tumor replacement therapy, among which photothermal therapy using laser heating to treat tumors has been developed rapidly. This technology mainly uses specifically targeted nanoparticles to gather in the tumor area, so as to convert light energy into heat energy more efficiently, increase the temperature of the tumor area, kill cancer cell...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/06
CPCA61N5/062A61N2005/0626
Inventor 任亚涛齐宏陈琴姚港李华欣
Owner HARBIN INST OF TECH
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