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Magnesium-zinc ferrite for tumor hyperthermia and preparation method thereof

A ferrite, magnesium-zinc technology, applied in the intersection of materials science and biomedicine, can solve the problems of little research on other magnetic ferrite materials, and achieve good industrial application prospects, good magnetic properties and magnetocaloric properties, Simple preparation method

Active Publication Date: 2019-11-12
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, MnZn ferrite nanoparticles are the most researched tumor hyperthermia materials in academia, but little research has been done on other magnetic ferrite materials.

Method used

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  • Magnesium-zinc ferrite for tumor hyperthermia and preparation method thereof
  • Magnesium-zinc ferrite for tumor hyperthermia and preparation method thereof
  • Magnesium-zinc ferrite for tumor hyperthermia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Doped with Mg 2+ , Zn 2+ The molar ratio is (mol%): Mg 2+ Ion 90, Zn 2+ ion 10.

[0082] 1) Accurately weigh the analytically pure MgCl 2 ·6H 2 O3.6598g, ZnCl 2 0.2726g, FeCl 3 ·6H 2 O11.0103g was dissolved in 120ml of distilled water to prepare a metal cation solution, and then the metal cation solution was thoroughly mixed using a magnetic stirrer and heated to 60°C.

[0083] 2) Accurately weigh 6.4208g of analytically pure granular NaOH, dissolve it in 400ml of distilled water to configure the solution, then heat the NaOH solution to 60°C, quickly transfer it to the hot cation solution, and keep stirring and heating for about 1 hour until completely precipitation.

[0084] 3) Continue heating at a temperature of 100° C. for 2 hours, then turn off the heating, and continue stirring for 6 hours.

[0085] 4) The precipitated particles were washed several times, dried at 80° C. for 3 h, and at 120° C. for 3 h, and ground into powder in an agate mortar after coo...

Embodiment 2

[0091] Doped with Mg 2+ , Zn 2+ The molar ratio is (mol%): Mg 2+ Ion 50, Zn 2+ ion 50.

[0092] 1) Accurately weigh the analytically pure MgCl 2 ·6H 2 O2.0356g, ZnCl 2 1.3655g, FeCl 3 ·6H 2 O10.9155 g was dissolved in 120 ml of distilled water to prepare a metal cation solution, and then the metal cation solution was thoroughly mixed using a magnetic stirrer and heated to 60°C.

[0093] 2) Accurately weigh 6.4124g of analytically pure granular NaOH, dissolve it in 400ml of distilled water to configure the solution, then heat the NaOH solution to 60°C, quickly transfer it to the hot cation solution, and keep stirring and heating for about 1 hour until it is completely precipitation.

[0094] 3) Continue heating at a temperature of 100° C. for 2 hours, then turn off the heating, and continue stirring for 6 hours.

[0095] 4) The precipitated particles were washed several times, dried at 80° C. for 3 h, and at 120° C. for 3 h, and ground into powder in an agate mortar a...

Embodiment 3

[0099] Doped with Mg 2+ , Zn 2+ The molar ratio is (mol%): Mg 2+ Ion 40, Zn 2+ ion 60.

[0100] 1) Accurately weigh the analytically pure MgCl 2 ·6H 2 O1.6254g, ZnCl 2 1.6363g, FeCl 3 ·6H 2 O10.9132 g was dissolved in 120 ml of distilled water to prepare a metal cation solution, and then the metal cation solution was thoroughly mixed using a magnetic stirrer and heated to 60°C.

[0101] 2) Accurately weigh 6.4575g of analytically pure granular NaOH, dissolve it in 400ml of distilled water to configure the solution, then heat the NaOH solution to 60°C, quickly transfer it to the hot cation solution, and keep stirring and heating for about 1 hour until completely precipitation.

[0102] 3) Continue heating at a temperature of 100° C. for 2 hours, then turn off the heating, and continue stirring for 6 hours.

[0103] 4) The precipitated particles were washed several times, dried at 80° C. for 3 h, and at 120° C. for 3 h, and ground into powder in an agate mortar after c...

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Abstract

The invention discloses a magnesium-zinc ferrite for tumor hyperthermia and a preparation method thereof, and belongs to the crossing field of material science and biomedicine. The magnesium-zinc ferrite Mg(1-x)ZnxFe2O4 (x is not less than 0.1 and not greater than 0.9) has a particle diameter of 20-100 nm; molar percentages of Mg<2+> and Zn<2+> in the magnesium-zinc ferrite are 90-10 mol% and 10-90 mol%, respectively. The preparation method provided by the invention is simple and does not require expensive equipment; in addition, the prepared magnesium-zinc ferrite has good magnetic propertiesand magnetocaloric properties, can be heated within a range of 43-50 DEG C or heated to 60 DEG C or higher rapidly under induction of an external magnetic field with a frequency of 215 kHz, and is predictably applied to the tumor hyperthermia, so that the magnesium-zinc ferrite provided by the invention has excellent industrial application prospects and practical application values.

Description

technical field [0001] The invention belongs to the intersecting field of material science and biomedicine, and particularly relates to a magnesium-zinc ferrite with magnetocaloric effect which can be used for tumor hyperthermia in a living body and a preparation method thereof. Background technique [0002] Tumor hyperthermia not only has the ability to kill broad-spectrum malignant tumors, but also can be combined with chemotherapy and radiotherapy to produce synergistic sensitization effects in clinical treatment. At the same time, it can reduce the toxic and side effects of radiotherapy and chemotherapy, so it is called "green therapy" by the international medical community. Tumor hyperthermia uses the different sensitivity of tumor cells and normal cells to heat. By injecting or implanting magnetic nanoparticles into the tumor site, it generates energy under the action of an external magnetic field, and then releases the generated energy to the tumor tissue. , resultin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G49/00B82Y40/00A61K41/00A61P35/00H01F1/01
CPCA61K41/0052A61P35/00B82Y40/00C01G49/0063C01P2002/72C01P2002/85C01P2004/03C01P2004/64H01F1/017
Inventor 李爱民刘慧莹丁鑫鑫孙康宁
Owner SHANDONG UNIV
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