100 results about "Kinetic curve" patented technology

The invention pertains to methods and devices for controlling the pharmacokinetics of administered substances, particularly therapeutic substances by combining advantages of delivery to two or more compartments within the skin. The invention provides methods and devices for delivering substances to subcutaneous and intradermal compartments of the skin to achieve a hybrid pharmacokinetic profile that has a portion similar to that achieved by intradermal delivery, e.g., rapid and high peak onset levels of the substance, and a portion similar to that achieved by subcutaneous delivery, e.g., longer circulating levels of the substance.

The present invention relates to the molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect. Moreover, the high loading efficiency of hydrophilic drugs can be achieved.

The invention provides a transient fluorescence lifetime measurement method based on single photon counting, which includes the following steps that: 1) a sample is irradiated by pulse light with high recurrence frequency to excite fluorescence; 2) the fluorescence lifetime of the sample is induced to have transient changes according to a certain period; 3) the fluorescence photons of the sample are detected and the corresponding high-speed digital pulse signals which represent the single photon signals are outputted; 4) the macro times of the photons are divided into different time zones, the photons are allocated to different groups according to the macro time and the groups correspond to the time zones of the macro time of the photons; and 5) time-relevant single photon counting is conducted on the photons in each macro time zone according to the high-speed digital pulse signals so as to get a fluorescence decay curve of the fluorescence photons in the macro time zone relative to time. In such way, the fluorescence decay curves in different macro time zones can be obtained. The invention further provides a corresponding transient fluorescence lifetime measurement system. The transient fluorescence lifetime measurement method and system are capable of recording the transient fluorescence decay dynamic curves of the nanosecond time sequence.

A system and method for accurately producing MR images of selected vascular compartments includes employing a control scan and a tag scan, each including velocity selective modules that suppress signal from blood flowing faster than a given cutoff velocity, to acquire control and tag sets of NMR data that may be subtracted to produce a compartment-specific MR image that is substantially free of information from stationary tissues and blood outside the selective vascular compartments. Accordingly, physiological parameters, such as oxygen saturation (SaO2), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2), can be generated from the compartment-specific images. Further still, kinetic curves of oxygen exchange can be created, thus providing detailed insight into oxygen exchange dynamics.

The invention provides a catalyst active ingredient used for propylene polymerization or copolymerization, a catalyst precursor containing the active ingredient, and a preparation method thereof. The catalyst active ingredient comprises a magnesium compound, a titanium compound Ti(OR)4-nXn, a chelated corrdination type electron donor, a selectively added diester electron donor, a siliceous electron donor, organic alcohol R'OH and halogenated hydrocarbons, wherein X is halogen; R is alkyl; n is 0 or an integer which is less than or equal to 4; and R' is alkyl. The catalyst precursor provided by the invention has the advantages of solid particles, high catalytic activity, stable dynamic curve, strong copolymerization performance, high hydrogen regulation sensitivity and so on, and a polypropylene product prepared by utilizing the catalyst precursor has the advantages of good particle shape, uniform particle size distribution, high fusion index of polymers, high bulk density and a small quantity of powder.

The invention discloses a preparation method of sliver / titanium dioxide film materials used for blue-ray holographic storage, and belongs to the field of optical information storage material preparation. The preparation method comprises the following steps: preparing a titanium dioxide film, tannin acid solution of which the pH (Potential Of Hydrogen) value is 8.5, silver nitrate solution and a titanium dioxide film attached with tannin acid, obtaining a sliver / titanium dioxide film with a water bath heating method, and carrying out a spectrum test and holographic storage on the sliver / titanium dioxide film. According to the preparation method, the tannin acid is used as reductant to obtain the sliver / titanium dioxide film materials. Through the detection of an absorption spectrum, compared with a traditional preparation method, the preparation method has the advantages of strong adsorption at a position of short wave and narrow absorption peak and is suitable for the holographic storage of short-wave light. The observation of a kinetic curve of holographic grating growth proves that the efficient and quick holographic storage of short-wavelength blue ray can be realized by the sliver / titanium dioxide film materials prepared with the preparation method.

The invention discloses a metal hydride thermal adsorption and desorption hydrogen cycling comprehensive test device, which consists of a gas cycling system, a sample chamber heating and cooling system and a computer data collection and control system. The gas cycling system provides a vacuum environment and high-purity hydrogen source to the test system; the sample chamber heating and cooling system rapidly and circularly heats and cools the test sample; and the computer data collection and control system controls a heating and cooling program to run and controls the opening and closing of relevant electromagnetic valve and electric valve and instantly collect the pressure and temperature signal of the system. While completing the test of the cycle of the metal hydride thermal adsorption and desorption of hydrogen, the system also can test the alloy adsorption and desorption hydrogen performance such as PCT curve and dynamics curve and the constant-temperature adsorption and desorption hydrogen service life in situ.

The invention relates to a testing apparatus capable of simulating high-temperature corrosion. The testing apparatus comprises a high-temperature corrosion system, a gas supply system, an electronic control system and an exhaust gas treatment system, wherein the high-temperature corrosion system comprises a heating furnace and a weighing device; the surface of a sample can be selectively coated with a variety of corrosive salt layers; the gas supply system can selectively input various corrosive gases into the heating furnace; the electronic control system comprising a weight recording unit and a displaying unit; the weight recording unit can record the real-time weight of the sample and calculate the weight gain of sample; the display unit can display an obtained kinetic curve of high-temperature corrosion; and the exhaust gas treatment system can recover the corrosive gases from the heating furnace. The testing apparatus of the invention is highly intelligent and automatic, and can display real-time kinetic curves of corrosion during simulated corrosion testing, so the system is well guaranteed in convenient study of the high-temperature corrosion behaviors and corrosion mechanisms of metal materials in environments with coexisting high-temperature gases, high-temperature salts and various corrosive media.

Methods for determining viable cell numbers and percentages are provided. The kinetic profile of a metabolic indicator associated with the cells may be analyzed to determine the number of viable cells in the starting population. Cells may be cultured with a molecule of interest and the effect of that molecule on the kinetic profile can be related to the susceptibility of the cells to the molecule of interest.

The invention relates to supported Ziegler-Natta catalyst components based on water-bearing silica gel (water content 0.5-8.0wt percent), which comprises the supported Ziegler-Natta catalyst and catalyst components of the supported Ziegler-Natta catalyst components, and a preparation method of the catalyst. The supported Ziegler-Natta catalyst is applied to homopolymerization of catalytic olefin and copolymerization of two or more than two different olefins. The supported Ziegler-Natta catalyst of the invention has low production cost, stable and easily controllable kinetic curve when being used in homopolymerization and copolymerization of catalytic olefin and stable active release; besides, polymers produced by the invention have low contend of fine powder and oligomer of the polymer and narrow particle size distribution of the polymer.

The invention discloses a test method of metal hydride thermal adsorption and desorption of hydrogen cycle life and a special device thereof. The test device consists of a gas cycling system, a sample chamber heating and cooling system and a computer data collection and control system. The gas cycling system provides a vacuum environment and high-purity hydrogen source to the test system; the sample chamber heating and cooling system rapidly and circularly heats and cools the test sample; and the computer data collection and control system controls a heating and cooling program to run and controls the opening and closing of relevant electromagnetic valve and electric valve and instantly collect the pressure and temperature signal of the system. While completing the test of the cycle of the metal hydride thermal adsorption and desorption of hydrogen, the system also can test the alloy adsorption and desorption hydrogen performance such as PCT curve and dynamics curve and the constant-temperature adsorption and desorption hydrogen service life in situ.

The invention relates to a method for determining a strain-induced martensite phase transformation kinetics curve. The method comprises the following steps: S1, preparing a metal material containing ametastable austenite phase into a standard stretching test sample, and performing the stretching test to obtain a stress-strain curve; S2, preparing the metal material containing the metastable austenite phase into a stepped stretching test sample with N deformation sections, performing the stretching test under a same environment and strain rate with the step S1 until the test sample is broken;S3, determining a strain-induced martensite content fa' of N deformation section characteristic parts in the step S2; S4, obtaining N groups of strains sigma corresponding to a determination positionin step S3; and S5, obtaining a strain-induced martensite phase transformation kinetics curve containing a metastable austenite phase metal material. The method has the advantages that aiming at the metastable austenite phase metal material, while the metastable austenite phase metal material stress-strain curve data is measured, the strain-induced martensite transformation kinetics curve of the metalstable austenite phase metal material can also be measured, so that double benefits can be achieved.

A system and method for accurately producing MR images of selected vascular compartments includes employing a control scan and a tag scan, each including velocity selective modules that suppress signal from blood flowing faster than a given cutoff velocity, to acquire control and tag sets of NMR data that may be subtracted to produce a compartment-specific MR image that is substantially free of information from stationary tissues and blood outside the selective vascular compartments. Accordingly, physiological parameters, such as oxygen saturation (SaO2), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2), can be generated from the compartment-specific images. Further still, kinetic curves of oxygen exchange can be created, thus providing detailed insight into oxygen exchange dynamics.

The present invention discloses a kind of P450BM-3Asp168Leu variant gene capable of catalyzing indole to generate indigo blue, and the gene is obtained by means of saturated mutation and directional evolution technology mediated random mutation and screening. The P450BM-3Asp168Leu variant gene has base sequence as shown in SEQ ID No. 1 of the sequence list, and the aspartic acid codon in the 168-th site of the original P450BM-3(F87V / A74G / L188Q) gene mutated into leucine codon. The enzymic kinetic curve measurement shows that the variant enzyme the obtained variant gene expresses has catalysis efficiency obviously higher than that in available technology. The present invention provides new practical enzyme for the biological synthesis of dye indigo blue and wide application foreground for the biological production of dye indigo blue.

The invention discloses an auxiliary standing chair and a research method for the movement track thereof. The method comprises the following steps: the AMTI three-dimensional force measuring platformis used for three-dimensional pressure measurement in the process of the human body standing up, and the pressure change curve is obtained in the process of the movement; a VICON gait capture system is used to carry out dynamic measurement of the center of gravity of human body in the process of standing-up motion, the track of the center of gravity of human body is obtained, and the dynamic curveis obtained by taking a second derivative. The pressure curve measured by AMTI three-dimensional dynamometer is combined with the track of human body center of gravity, the movement of human body isdivided into three phases, and the three phases are analyzed one by one. The auxiliary kinetic parameters of each stage were obtained. The invention has the beneficial effects that the working efficiency of the seat and the comfort degree of the person are improved, the safety and the reasonable safety speed can ensure that the body of the elderly and the patient is not injured and can also standsafely, and the problem that the hip joint trajectory measurement and the dynamic parameters thereof are difficult to be accurately determined is solved.

The present invention discloses one kind of P450BM-3Asp168His variant gene capable of catalyzing indole to generate indigo blue, and the gene is obtained by means of saturated mutation and directional evolution technology mediated random mutation and screening. The P450BM-3Asp168His variant gene has base sequence as shown in SEQ ID No. 1 of the sequence list, and the aspartic acid codon in the 168-th site of the original P450BM-3(F87V / A74G / L188Q) gene mutated into histidine codon. The enzymic kinetic curve measurement shows that the variant enzyme the obtained variant gene expresses has catalysis efficiency obviously higher than that in available technology. The present invention provides new practical enzyme for the biological synthesis of dye indigo blue and wide application foreground for the biological production of dye indigo blue.

The invention discloses a real-time fluorescent PCR method for testing the allergen genes of aquatic food, comprising the following steps: total RNA of samples is extracted; the allergen genes Par and TM of aquatic food, and internal standard gene Beta-actin are respectively tested by SYBR Green or TaqMan probe real-time fluorescent PCR technology; and result analysis is carried out to the tested samples according to the amplification kinetic curve and the Ct value. As the real-time fluorescent PCR technology is used for testing the allergen genes Par and TM of aquatic food, compared with other methods, the method has the advantages of high sensitivity, short testing time, available quantitative analysis, and the like, and can be used in the qualitative screening, quantitative analysis and confirmation identification of allergen genes in unknown species or mixed samples of aquatic food.

The present invention relates to systems and methods for obtaining optimized EPO dosage regimens for a desired pharmacodynamic / pharmacokinetic response. The system includes choosing one or more EPO dosage regimens, then using a PK / PD model to determine the pharmacodynamic / pharmacokinetic profile of one or more EPO dosage regimens, and finally selecting one of the EPO dosage regimens for administration to achieve the desired pharmacodynamic / pharmacodynamic response based on the EPO profile.

The invention discloses a method for rapidly detecting a photosynthetic rate of phytoplankton based on chlorophyll fluorescence. According to the invention, from the view of energy flow angle of photosynthesis, the chlorophyll fluorescence serves as a probe of photosynthesis, a variable light pulse induction method for phytoplankton chlorophyll fluorescence is provided, the complex photosynthetic energy flow process is segmented, and photosynthetic parameters for leading the photosynthetic energy flow efficiency are obtained in a sectional mode by analyzing the chlorophyll fluorescence kinetic curves under different induction modes. On the basis, according to the biological film energy flow process, a quantitative analysis method for the photosynthetic rate of phytoplankton based on chlorophyll fluorescence is established, the state and growth potential of the photosynthesis of the phytoplankton are rapidly detected in real time, and a method basis is provided for developing an in-situ field measurement technology.

The present invention discloses a kind of P450BM-3Glu435Thr variant gene capable of catalyzing indole to generate indigo blue, and the gene is obtained by means of saturated mutation and directional evolution technology mediated random mutation and screening. The P450BM-3Glu435Thr variant gene has base sequence as shown in SEQ ID No. 1 of the sequence list, and the aspartic acid codon in the 435-th site of the original P450BM-3(F87V / A74G / L188Q) gene mutated into threonine codon. The enzymic kinetic curve measurement shows that the variant enzyme the obtained variant gene expresses has catalysis efficiency obviously higher than that in available technology. The present invention provides new practical enzyme for the biological synthesis of dye indigo blue and wide application foreground for the biological production of dye indigo blue.

The invention discloses an early prediction method for rape yield, which includes the following steps: (1) rape, the variety and growing state of which are the same as the variety and growing state of rape to be predicted, is chosen as a model sample, a chlorophyll fluorescence induction kinetics curve of pods of the model sample is acquired, and fluorescence parameters are extracted as feature parameters of the model sample; (2) after the pods of the model sample are harvested, the weight of the seeds of the pods is acquired as a yield value of the model sample; (3) according to the extracted feature parameters and yield value, a suitable machine learning regression model is chosen and trained, so that a quantitative prediction model is obtained; (4) the chlorophyll fluorescence induction kinetics curve of pods of the rape to be predicted is acquired, feature parameters are extracted, and according to the feature parameters of the rape to be predicted and the quantitative prediction model, the early prediction of the yield of the rape to be predicted is carried out. The invention further discloses a rapeseed pod-shading device. The early prediction method for rape yield disclosed by the invention can carry out early prediction on rape yield at the stage of rapeseed pods, and the prediction result is reliable.

The present invention relates to a catalyst for polymerization of ethylene, a process for preparing the same, and a method for controlling kinetic behavior of said catalyst in ethylene polymerization. Said catalyst contains a titanium-containing main catalyst component and a co-catalyst. The titanium-containing main catalyst component is prepared by reacting the following components: (1) a hydrocarbon solution of dialkylmagnesium compound of formula RMgR′.yEt3Al; (2) an alcohol compound of formula R1OH; (3) a silica support thermally activated at 200-800° C.; (4) an alkylaluminum compound of formula R2nAlCl3-n; (5) a linear halogenated alkane of formula R3X; and (6) a titanium compound of formula Ti(OR4)mCl4-m. The co-catalyst is an organoaluminum compound. Three different types of ethylene polymerization kinetic curves can be obtained by adjusting the temperature for thermally activating the silica support and the ratio of titanium to magnesium in the titanium-containing main catalyst component.

The invention discloses a homogeneous chemiluminescence immunoassay method for measuring an organophosphorus pesticide Dursban and belongs to the technical fields of pesticide residue analysis and chemiluminescence immunoassay. The method comprises the following steps: 1) activating the organophosphorus pesticide Dursban and introducing an active group carboxyl group so as to acquire the activated organophosphorus pesticide Dursban; 2) marking the chemiluminescence agent luminol onto bovine serum albumin (BSA) so as to acquire the luminol-BSA, wherein the coupling ratio reaches (1:20) to (1:40); 3) marking the activated organophosphorus pesticide Dursban onto the luminol-BSA, so as to acquire a Dursban chemiluminescence marker; 4) drawing a luminescence kinetics curve of the Dursban chemiluminescence marker, wherein a time axis is used as the horizontal ordinate and the relative luminous intensity is used as the vertical coordinate; and 5) establishing a homogeneous chemiluminescence immunoassay direct competition method to confirm the linear relationship between the luminous intensity and the antigen concentration of a sample to be identified. The method provided by the invention is suitable for the speedy qualitative and quantitative analysis detection for the Dursban on site.

The invention discloses a testing device and method for high temperature oxidation properties of a material under stress action. The testing device comprises an automatic temperature control furnace, wherein a stress loading rod is arranged in the automatic temperature control furnace; a plurality of gas cylinders are communicated with the interior of the automatic temperature control furnace through a gas mixing collecting box. The testing method comprises the following steps: fixing a sample onto the stress loading rod, and then loading the assembled stress loading rod into the automatic temperature control furnace; fixing one end of the stress loading rod and connecting the other end of the stress loading rod with a weight; opening the valves of the gas cylinders to enable gases to be fully mixed in the gas mixing collecting box and then introducing the mixed gas into the automatic temperature control furnace to be heated; after sample oxidation, taking out the sample and weighing, so as to obtain an oxidation kinetic curve of the sample under the condition of bearing tensile stress. According to the invention, the weight is adopted for stress loading, the temperature control furnace of a sealing structure is adopted for providing the temperature environment, where the sample is positioned, and a flow control mechanism is adopted for providing the oxidizing atmosphere, where the sample is positioned, so that influences of stress oxidation on materials is researched more comprehensively.

The invention discloses a VPCE (vapor phase catalytic exchange) static performance testing method. The method comprises the following steps: S1, putting a catalyst to be detected and analyzed in a reaction tank, and closing; S2, vacuumizing a reaction vessel: washing several times, and then vacuumizing the reaction vessel; S3, separating a mixing tank and the reaction tank to form independent spaces; and introducing pure hydrogen into the mixing tank, and injecting deuterium-containing water into the mixing tank; S4, regulating a temperature control device, so that the temperature of the reaction vessel reaches a preset temperature value; monitoring a pressure sensor and a temperature sensor of the mixing tank and the reaction tank; when the temperature and pressure from the both reach preset requirements, enabling the mixing tank to communicate with the reaction tank; and reacting deuterium-containing vapor and hydrogen gas in the presence of a hydrophilic catalyst; and S5, sampling and detecting: sampling from the reaction tank at set intervals, detecting and analyzing. The VPCE static performance testing method disclosed by the invention can accurately acquire the kinetic curve, equilibrium constant, separation factor and other parameters of hydrogen-water isotope catalytic exchange reaction.

The invention relates to a SYBR green I fluorogenic quantitative PCR (polymerase chain reaction) detecting method of pig proliferative enteropathy Lawsonia Intracellularis. The method provided by the invention comprises the following steps of: extracting pig Lawsonia Intracellularis DNA, designing primers, carrying out PCR amplification on aspa gene segments of PPE (polyphenylene oxide polyphenyl ether), cloning and identifying aspa genes of pig proliferative enteropathy, preparing a standard plasma template, amplifying fluorogenic quantitative PCR so as to obtain an amplification kinetic curve and a standard curve, testing the specificity, the sensitivity, the repeatability and stability, and detecting clinical disease material samples. The method provided by the invention has favorable specificity, sensitivity, repeatability and stability, and can identify and diagnose clinical suspected PPE infected or morbidity pigs simply, conveniently, rapidly, specifically, sensitively and accurately, and can detect and monitor the infection in the early stage.

The invention provides a kit for fluorescence real-time quantitative PCR detection of Laribacter hongkongensis and a detection method thereof. The kit contains separation agents of lysis solution, protease K, extraction solution, TE buffer solution, fluorescence PCR reaction solution, ROX dye, positive control solution and negative control solution. The detection method comprises the following steps: preliminary treatment is carried out on a sample to obtain a sample PCR template; the fluorescence PCR reaction solution, the sample PCR template, the positive control solution and the negative control solution or the inner reference dye are added into a PCR reaction tube to carry out an amplification reaction; and whether the Laribacter hongkongensis exists in the intestinal tract of a freshwater fish or not is quantitatively detected through analyzing the Ct values and a dissolution kinetic curve. The method is simple and fast, and has favorable specificity and high sensitivity, great social and economic benefits for improving the edible security of freshwater products and very high practical value.

When cold and in the non-coated state, the aerodynamic profile is substantially identical to a nominal profile determined by the Cartesian coordinates X,Y, Zadim given in Table 1, in which the coordinate Zadim is the quotient D / H where D is the distance of the point under consideration from a first reference plane P0 situated at the base of the nominal profile, and H is the height of said profile measured from the first reference plane to a second reference plane P1. The measurements D and H are taken radially relative to the axis of the turbine, while the X coordinate is measured in the axial direction of the turbine.

The invention relates to the technical field of nanometer biology and particularly relates to a method of detecting quantum dot-protein binding kinetics. According to a technical scheme, the method researches the binding kinetics between quantum dots and protein through fluorescent capillary electrophoresis and fits a binding kinetic curve by the hill equation. By adoption of the technical scheme, the beneficial effects of the method are that the method is suitable for research on binding kinetic changes of the quantum dots and the protein outside and inside capillaries, broadens the application range of capillary electrophoresis, and provides theoretical bases for further application of quantum dot biological probes.

The invention discloses a method of measuring the variable-pressure absorption gas separation performance of a carbon molecular sieve on the basis of a liquid absorption gas flooding principle. According to the method, a carbon molecular sieve of a saturated adsorption gas probe is immersed into a liquid probe; a liquid absorption gas flooding experiment is performed under a constant volume condition; a liquid absorption gas flooding kinetic curve and a balanced gas flooding quantity are obtained. Through the adsorption kinetic model simulation, the dynamic mechanism and the gas selectivity coefficient K are determined, and are used for judging the micropore opening dimension relative dimension rule, the distribution uniformity and the micropore volume relative dimension of the carbon molecular sieve; further, the method for evaluating the variable-pressure adsorption gas separation performance of the carbon molecular sieve is built. The method has the advantages that the carbon molecular sieve with the micropore opening dimension and the micropore volume meeting the gas separation requirement can be accurately judged in the aspects of the adsorption mechanism and the pore structure; high selectivity can be ensured; higher adsorption volume can also be ensured.