32 results about "Furazolidonum" patented technology

The present invention relates to a furazolidone tablet preparation method, which is performed according to the following steps: taking furazolidone, a binder and a solubilizer, screening, respectively screening a lubricant and a flow aid with a 80-120 mesh sieve, adding water or an alcohol to the partial binder having the content of more than or equal to 28% of the total amount of the binder and the partial solubilizer having the content of more than or equal to 14% of the total amount of the solubilizer to prepare a binder solution with a mass concentration of 1-30%, uniformly mixing the remaining binder and the remaining solubilizer, uniformly mixing with the furazolidone according to an equivalent gradual increase method, adding the binder solution to prepare a soft material, carrying out 12-30 mesh pelletization, drying at a temperature of less than 70 DEG C, carrying out 12-30 mesh granulating, adding a lubricant and a flow aid, uniformly mixing, and tabletting to obtain the finished product. According to the present invention, the reasonable process operation sequence is adopted, the part of the solubilizer is adopted to increase furazolidone hydrophilicity, and the part of the solubilizer is adopted to promote furazolidone self-emulsifying and increase solubility in water so as to improve a dissolution rate and increase bioavailability.

The invention relates to a medicine for treating hepatomegaly. The medicine for treating the hepatomegaly comprises the medicinal raw materials as follows: 7g of gastrodia elata, 7g of Rhizoma Pinelliae, 7g of taro pulp, 5g of pharbitis seed, 3g of garden burnet, 3g of Astragalus mongholicus, 5g of fructus psoraleae and 5g of date kernel; and the medicine for treating the hepatomegaly also comprises the components as follows: 20 furazolidone tablets, 20 terramycin tablets, 15 compound acetylsalicylic acid tablets, 2 belladonna tablets and 5 flu-treating capsules. The medicine for treating the hepatomegaly has the advantages that the medicine for treating the hepatomegaly can treat hepatomegaly caused by various reasons, has an obvious therapeutic effect and takes effect quickly; and through combined therapy of the traditional Chinese medicine and Western medicine, the used Western medicinal raw materials are finished medicines sold in the market, with wide source, easy obtainment and low price, so that the medicine for treating the hepatomegaly is low in cost and high in cost performance.

The invention belongs to the field of organic chemical synthesis, and particularly relates to a synthesis method of furazolidone. The synthesis method comprises the following steps: introducing gasified ethylene oxide into a hydrazine hydrate through a coiler placed in hot water so as to prepare beta-hydroxyethylhydrazine; after cooling the beta-hydroxyethylhydrazine, adding sodium methoxide methyl alcohol solution and then stirring, and adding dimethyl carbonate so as to prepare 3-amino-2-oxazolidinone; and adding water in 3-amino-2-oxazolidinone, adding hydrochloric acid, rising the temperature, adding 5-nitryl furfural ester diacetate, and carrying out periodical warming so as to obtain the finished furazolidone. By using the synthesis method, the problems that the process is not environment-friendly, the requirement on equipment is high, the yield of the product is low, and the like in the prior art are effectively solved, and the yield of the product in the invention can be improved by 5-10%.

A method for preparing immune nanogold test paper used to quickly detect furazolidone includes synthesizing coupled matter of flurazolidone-cattle seralbumin and coupled matter of flurazolidone-catalase ; using coupled matter of flurazolidone-cattle seralbumin as immune total antigen; making immune experiment on rabbit to obtain multiple clone antibody of rabbit resistance furazolidone; preparing nanogold reagent being used to label said antibody; fixing IgG antibody and coupled matter of furazolidone-catalase on nitrocellulose film; sealing unreacted active group; using above-prepared film, antibody and paper as well as sample pad to form said test paper.

The invention provides a method for detecting furazolidone by electrochemiluminescence method, which uses aminated manganese dioxide / nano gold / modified SnO doped with fluorine 2 Transparent film (FTO) (NH‑MnO 2 / NAu / FTO) conductive glass as the working electrode, the Ag / AgCl electrode as the reference electrode, and the platinum electrode as the auxiliary electrode to form a three-electrode system; using the electrostatic interaction between amino groups and negatively charged gold nanoparticles, the composite material It is fixed on FTO, and furazolidone is adsorbed, and furazolidone is detected by electrochemiluminescence. The detection range of this method is 1.0×10 ‑8 mol / L‑1.0×10 ‑ 5 mol / L, the lowest detection limit is 6.6×10 ‑9 mol / L. The sensor prepared by the invention has the advantages of low cost, high sensitivity, simple operation and good selectivity for detecting furazolidone.

The invention discloses a preparation method of an electrochemiluminescent furazolidone biosensor. It belongs to the technical field of new nanometer functional materials and biosensors. The present invention first prepares a novel two-dimensional nanocomposite material Mn-TiO2 / g-C3N4, utilizes the good biocompatibility and large specific surface area of ​​the material, loads furazolidone antibody, and then cross-links through glutaraldehyde Acting on horseradish peroxidase, when detecting, because horseradish peroxidase can catalyze hydrogen peroxide to generate oxygen in situ, and then electrochemically react with the bottom liquid to produce high and stable electrochemiluminescence signal, and then use the effect of the specific quantitative combination of antibody and antigen on the electron transport ability, so that the electrochemiluminescent signal is correspondingly reduced, and finally a low-cost, high-sensitivity, good specificity, rapid detection, and simple preparation method for the detection of furazolidone was obtained. Electrochemiluminescent biosensors.

The invention discloses a furazolidone AOZ-D4 synthesis method, which comprises: 1) carrying out a reaction on deuterated acetic acid and bromine in the presence of TFAA to obtain deuterated bromoacetic acid; 2) carrying out a reaction on the deuterated bromoacetic acid and oxalyl chloride (or SOCl2) in DMF, adding benzyl alcohol, and continuously carrying out a reaction to obtain deuterated benzyl bromoacetate; 3) adding the deuterated benzyl bromoacetate into the THF solution of NaBD4, and carrying out a reaction to obtain deuterated bromoethanol; 4) dissolving hydrazine hydrate in dehydrated alcohol, adding NaOH, stirring, adding the deuterated bromoethanol, and carrying out a reaction to obtain deuterated 2-hydroxyethyl hydrazine; and 5) carrying out a reaction on the deuterated 2-hydroxyethyl hydrazine and dimethyl carbonate in the presence of an alkali to synthesize furazolidone AOZ-D4.

The invention discloses a preparation method of 3-amino-2-oxazolidinone (AOZ). The method comprises the following steps: 1) carrying out a reaction on ethylene glycol and PBr3 to obtain 2-bromoethanol; 2) in the presence of an alkali, carrying out a reaction on NH2NH2Boc and 2-bromoethanol to obtain Boc protected 2-hydrazinoethanol; 3) in the presence of an alkali, carrying out a reaction on Boc protected 2-hydrazinoethanol and diethyl carbonate to obtain Boc protected 3-amino-2-oxazolidinone; and 4) performing deprotection on the Boc group in the Boc protected 3-amino-2-oxazolidinone to obtain 3-amino-2-oxazolidinone. According to the method, the yield of AOZ in the synthesis process is obviously increased, and separation and purification are facilitated.

The invention relates to a low-carbon mixed organic acid used for oil well plug removal, a preparation method and an application thereof. The low-carbon mixed organic acid is prepared from the following raw materials by mass percent: 4-6 % of fatty alcohol, 2.4-2.5 % of ethylene oxide, 4-6 % of alkylbenzenesulfonate, 34-36 % of sulfamic acid, 24-26 % of oxalic acid, 4-6 % of biuret, 8-12 % of furazolidone, 8-12 % of 3-benzofuranone and 2.4-2.6 % of sodium nitrite. The low-carbon mixed organic acid is mainly used in a late stage of heavy oil throughput in Liaohe oilfield so as to improve single well production, especially to remove oil reservoir plug during each throughput, and is relatively substantial in improving steam throughput exploitation effects.