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High performance liquid chromatography detection method of indometacin furazolidone suppository

A technology of indomethacin furazolidone and high-performance liquid chromatography, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of low specificity and accuracy, strong solvent irritation, and low safety, and achieve HPLC Conditional durability, fast analysis speed, and easy handling of effects

Inactive Publication Date: 2020-10-30
武汉药品医疗器械检验所
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  • Abstract
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  • Application Information

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Problems solved by technology

This method is cumbersome and uses a specific formula to calculate the results, so that the content results of the two components affect each other, the specificity and accuracy are not high, and the solvent is more irritating and the safety is not high

Method used

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  • High performance liquid chromatography detection method of indometacin furazolidone suppository
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  • High performance liquid chromatography detection method of indometacin furazolidone suppository

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Embodiment 1

[0040] 1. Chromatographic conditions (operation protected from light)

[0041] Chromatographic column: octadecyl bonded silica chromatographic column;

[0042] Mobile phase: acetonitrile-0.1mol / L glacial acetic acid solution (volume ratio 50:50), shake well;

[0043] Flow rate: 1.0ml / min;

[0044] Column temperature: 35℃;

[0045] Wavelength: 320nm.

[0046] 2. Preparation of the solution

[0047] ①Test solution

[0048] Take 10 capsules of this product, accurately weigh them, chop them, take appropriate amount of fragments (approximately equivalent to furazolidone 30mg and indomethacin 22.5mg), accurately weigh them, place them in a 250ml measuring flask, add 125ml of acetonitrile and ultrasound for 30 minutes to dissolve , Dilute with water to the mark, shake well, filter, accurately measure 5ml of the continuous filtrate, place it in a 10ml measuring flask, dilute to the mark with mobile phase, and shake well.

[0049] ②Reference substance solution

[0050] Take 24mg of furazolidone refe...

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Abstract

The invention discloses a high performance liquid chromatography detection method of an indometacin furazolidone suppository. A mobile phase of the high performance liquid chromatography detection method is formed by mixing acetonitrile and a 0.08-0.12 mol / L glacial acetic acid solution according to the volume ratio of (45-55): (55-45), and a stationary phase is a C18 silica gel chromatographic column. According to the method disclosed by the invention, the contents of two components, namely indometacin and furazolidone, are simultaneously separated and determined by adopting an HPLC method, the sample pretreatment and analysis method is simplified, the analysis efficiency of indometacin furazolidone suppository content determination is improved, and the method has the advantages of high analysis speed, high separation efficiency, high detection sensitivity, automation, wide application range and simple treatment.

Description

【Technical Field】 [0001] The invention relates to the field of drug analysis, in particular to a high-performance liquid chromatography detection method for indomethacin furazolidone suppositories. 【Background technique】 [0002] Indomethacin furazolidone suppository is a compound preparation with the main components of indomethacin and furazolidone suppository. It is a commonly used clinical anti-inflammatory and analgesic for hemorrhoids and is mainly used for internal hemorrhoids, external hemorrhoids, anal swelling, fistulas, anal fissures and other anorectal diseases and hemorrhoids Pain relief after fistula surgery. [0003] The existing content determination and analysis methods for indomethacin and furazolidone suppositories include WS-10001-(HD-1535)-2005 and WS-10001-(HD-0970)-2002, both of which are spectrophotometrically determined for indomethacin and furazolidone suppositories The content of the two components. The method is cumbersome and uses a specific formula to...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/32G01N30/34G01N30/30
CPCG01N30/02G01N30/06G01N30/32G01N30/34G01N30/30G01N2030/324
Inventor 戴黎黎李苗聂小春
Owner 武汉药品医疗器械检验所
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