74 results about "Ethoxybenzene" patented technology

The invention belongs to the field of photocuring materials and relates to a cleaning production method of 2-(Ethoxyethoxy) ethyl acrylate (EOEOEA) or phenoxyethyl acrylate (PHEA). The method comprises the following steps: (1) carrying out esterification, backflow and dehydration on diethylene Glycol monoethylether or ethylene glycol phenyl ether, acrylic acid, a catalyst, a solvent, a polymerization inhibitor and an antioxidant; (2) adding caustic soda flakes and little water for neutralization; (3) adding a polymagnesium silicate adsorbent for adsorbing and neutralizing the generated salt; (4) reducing pressure for dehydration and removing the solvent; (5) carrying out filter pressing so as to filter polymagnesium silicate and the salt adsorbed by polymagnesium silicate; (6) adding alkaline Ca-based bentonite and calcium oxide for decoloration, micro water removal and trace acid removal; (7) carrying out filter pressing; and (8) detecting product indexes. The cleaning production method disclosed by the invention has high yield and social and environmental benefits, thus thoroughly solving the organic waste water pollution problem during the production process of EOEOEA or PHEA.

The present invention discloses a method of preparing tamsulosin hydrochloride and subsequent purification by thermal crystallization to provide substantially pure tamsulosin hydrochloride.

The invention discloses a preparation method of 3-ethoxy-4-hydroxymandelic acid, which is an intermediate used in the synthesis of ethyl vanillin. The preparation method comprises the following steps: adding water into glyoxalic acid, well-mixing the mixture, and using a sodium hydroxide solution to regulate the pH value of the mixture to 5.0 to 5.5, such that a glyoxalic acid solution is obtained; adding water into 2-ethoxyphenol, well-mixing the mixture, and using the sodium hydroxide solution to regulate the pH value of the mixture to 10 to 12 under a temperature of 25 to 30 DEG C, such that a 2-ethoxyphenol solution is obtained; simultaneously dropping the glyoxalic acid solution and the sodium hydroxide solution into the 2-ethoxyphenol solution under a temperature of 25 to 30 DEG C, than heating the mixture to a temperature of 50 to 60 DEG C, stirring for 1 to 3 hours with the temperature maintained, such that 3-ethoxy-4-hydroxymandelic acid is obtained. According to the invention, through an optimized arrangement of reaction temperatures, the reaction time is substantially reduced, and the production yield is substantially increased.

The o-ethoxyl phenol synthesizing process with catechol and ethyl chloride as material includes the following steps: adding toluene and water into high pressure reactor, starting stirrer and water cooling the shaft of the high pressure reactor; adding catechol, sodium carbonate, alkyl amine bromide catalyst, solid sodium hydroxide, ethyl chloride in required amount successively; sealing, heating and maintaining at 100-139 deg.c and 0.1-1.1 MPa for 2-6 hr. The weight proportion among catechol, sodium hydroxide, sodium carbonate, ethyl chloride, alkyl amine bromide, water and toluene is 1 to 0.364-0.509 to 0.045-0.273 to 0.591-0.938 to 0.0091-0.0682 to 1.591-2.730 to 1.820-4.545. The present invention has yield of 86 %, and compared with other process, the present invention has lowered product cost, less sewage exhaust, low sewage COD, short technological process and less investment.

The invention relates to 1-[3-(6, 7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazole parallel [4, 3-d] pyridine-5-thyl)-4-ethoxylbenzene sulfonyl]-cis-3, 5-lupetazin citrate or citric acid alidenafil crystal form D and preparation method thereof and also relates to drug combination containing citric acid alidenafil crystal form D and application thereof in preparation of drug for treating erection disturbance. Citric acid alidenafil raw material is dissolved in distilled water / acetone mixed solution in certain proportion, and heat preservation is carried out for 50-72 hours while stirring is carried out at certain temperature, thus obtaining the product. Test by an X-ray powder diffractometer, thermogravimetric analysis and infrared spectrometer proves that an unprecedented citric acid alidenafil crystal form D is obtained, the crystal form D can form a combination with one or multiple pharmaceutically acceptable carrier, excipient or diluent and can be effectively applied to treatment on andropathy.

The invention relates to a crystal form V of 1-[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H- pyrazolo[4,3-d] 5-pyrimidinyl)-4-ethyoxylbenzenesulfonyl]-cis-3,5-dimethylpiperazine citrate or Aildenafil citrate, and a preparation method thereof. The preparation method comprises the following steps: dissolving raw materials of the Aildenafil citrate in distilled water, stirring, and raising temperature to a reflux temperature; and adding acetone solution, and stirring and raising temperature continuously. The prepared product meets product requirements after being tested by an X-ray powder diffractometer and an infrared spectrometer. The invention also relates to a medicinal composition comprising the crystal form V of the Aildenafil citrate, and application of the crystal form V of the Aildenafil citrate in preparing medicaments for treating erection disturbance (ED).

The invention relates to 1-[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazol[4,3-d] pyridine-5-group)-4-ethoxybenzene sulfonyl]-cis-3,5-lupetazin citrate or aildenafil citrate crystal form O and a preparation method thereof. The invention also relates to a medicine compound containing aildenafil citrate crystal form O and the application thereof in preparing the medicine for treating erectile dysfunction (ED). The aildenafil citrate crystal form O is formed by the steps of: solving citrate in the distilled water and tetrahydrofuran, stirring, rising temperature, filtering, stirring filtrate, decreasing temperature, crystallizing and filtering. The aildenafil citrate crystal form O is prepared into the medicine together with the medical excipients and is applied in treating the erectile dysfunction disease.